Y Chromosome and Mitochondrial DNA Characterization of Pasiegos, a Human Isolate from Cantabria (Spain)
Summary Mitochondrial DNA sequences and Y chromosome haplotypes were characterized in Pasiegos, a human isolate from Cantabria, and compared with those of other Cantabrian and neighbouring Northern Spain populations. Cantabria appears to be a genetically heterogeneous community. Whereas Lebaniegos d...
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| Veröffentlicht in: | Annals of human genetics 2003-07, Vol.67 (4), p.329-339 |
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| container_title | Annals of human genetics |
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| creator | Maca‐Meyer, N. Sánchez‐Velasco, P. Flores, C. Larruga, J.‐M. González, A.‐M. Oterino, A. Leyva‐Cobián, F. |
| description | Summary
Mitochondrial DNA sequences and Y chromosome haplotypes were characterized in Pasiegos, a human isolate from Cantabria, and compared with those of other Cantabrian and neighbouring Northern Spain populations. Cantabria appears to be a genetically heterogeneous community. Whereas Lebaniegos do not differ from their eastern Basque and western Asturian and Galician neighbours, Pasiegos and other non‐Lebaniego Cantabrians show significant differences with all of them. Pasiegos are peculiar for their high frequencies of Y chromosomal markers (E‐M81) with North African assignation, and Y chromosomal (R‐SRY2627) and mtDNA (V, I, U5) markers related to northern European populations. This dual geographic contribution is more in agreement with the complex demographic history of this isolate, as opposed to recent drift effects. The high incidence in Cantabrians with pre‐V and V mtDNA haplotypes, considered as a signal of Postglacial recolonization in Europe from south‐western refugees, points to such refugees as a better candidate population than Basques for this expansion. However, this does not discount a conjoint recolonization. |
| doi_str_mv | 10.1046/j.1469-1809.2003.00045.x |
| format | Article |
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Mitochondrial DNA sequences and Y chromosome haplotypes were characterized in Pasiegos, a human isolate from Cantabria, and compared with those of other Cantabrian and neighbouring Northern Spain populations. Cantabria appears to be a genetically heterogeneous community. Whereas Lebaniegos do not differ from their eastern Basque and western Asturian and Galician neighbours, Pasiegos and other non‐Lebaniego Cantabrians show significant differences with all of them. Pasiegos are peculiar for their high frequencies of Y chromosomal markers (E‐M81) with North African assignation, and Y chromosomal (R‐SRY2627) and mtDNA (V, I, U5) markers related to northern European populations. This dual geographic contribution is more in agreement with the complex demographic history of this isolate, as opposed to recent drift effects. The high incidence in Cantabrians with pre‐V and V mtDNA haplotypes, considered as a signal of Postglacial recolonization in Europe from south‐western refugees, points to such refugees as a better candidate population than Basques for this expansion. However, this does not discount a conjoint recolonization.</description><identifier>ISSN: 0003-4800</identifier><identifier>EISSN: 1469-1809</identifier><identifier>DOI: 10.1046/j.1469-1809.2003.00045.x</identifier><identifier>PMID: 12914567</identifier><identifier>CODEN: ANHGAA</identifier><language>eng</language><publisher>9600 Garsington Road , Oxford OX4 2DQ , UK , tel +44 1865 776868 , fax +44 1865 714591: Blackwell Science Ltd</publisher><subject>Biological and medical sciences ; Chromosomes, Human, Y - genetics ; DNA, Mitochondrial - genetics ; General aspects. Genetic counseling ; Genetics, Population ; Geography ; Haplotypes - genetics ; Humans ; Medical genetics ; Medical sciences ; mtDNA ; Pasiegos ; Phylogeny ; Polymorphism, Genetic - genetics ; Polymorphism, Restriction Fragment Length ; Population Dynamics ; Sequence Analysis, DNA ; Spain ; Y‐Chromosome</subject><ispartof>Annals of human genetics, 2003-07, Vol.67 (4), p.329-339</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3945-eea9e8038119a2fc68227f33b0452db345e552ae36f7a73d17ca0c859ed791383</citedby><cites>FETCH-LOGICAL-c3945-eea9e8038119a2fc68227f33b0452db345e552ae36f7a73d17ca0c859ed791383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1469-1809.2003.00045.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1469-1809.2003.00045.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14945126$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12914567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maca‐Meyer, N.</creatorcontrib><creatorcontrib>Sánchez‐Velasco, P.</creatorcontrib><creatorcontrib>Flores, C.</creatorcontrib><creatorcontrib>Larruga, J.‐M.</creatorcontrib><creatorcontrib>González, A.‐M.</creatorcontrib><creatorcontrib>Oterino, A.</creatorcontrib><creatorcontrib>Leyva‐Cobián, F.</creatorcontrib><title>Y Chromosome and Mitochondrial DNA Characterization of Pasiegos, a Human Isolate from Cantabria (Spain)</title><title>Annals of human genetics</title><addtitle>Ann Hum Genet</addtitle><description>Summary
Mitochondrial DNA sequences and Y chromosome haplotypes were characterized in Pasiegos, a human isolate from Cantabria, and compared with those of other Cantabrian and neighbouring Northern Spain populations. Cantabria appears to be a genetically heterogeneous community. Whereas Lebaniegos do not differ from their eastern Basque and western Asturian and Galician neighbours, Pasiegos and other non‐Lebaniego Cantabrians show significant differences with all of them. Pasiegos are peculiar for their high frequencies of Y chromosomal markers (E‐M81) with North African assignation, and Y chromosomal (R‐SRY2627) and mtDNA (V, I, U5) markers related to northern European populations. This dual geographic contribution is more in agreement with the complex demographic history of this isolate, as opposed to recent drift effects. The high incidence in Cantabrians with pre‐V and V mtDNA haplotypes, considered as a signal of Postglacial recolonization in Europe from south‐western refugees, points to such refugees as a better candidate population than Basques for this expansion. However, this does not discount a conjoint recolonization.</description><subject>Biological and medical sciences</subject><subject>Chromosomes, Human, Y - genetics</subject><subject>DNA, Mitochondrial - genetics</subject><subject>General aspects. Genetic counseling</subject><subject>Genetics, Population</subject><subject>Geography</subject><subject>Haplotypes - genetics</subject><subject>Humans</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>mtDNA</subject><subject>Pasiegos</subject><subject>Phylogeny</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Population Dynamics</subject><subject>Sequence Analysis, DNA</subject><subject>Spain</subject><subject>Y‐Chromosome</subject><issn>0003-4800</issn><issn>1469-1809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EotvCX0C-gKhEgj8TR-pltYVupfIhAQdO1qwzab1K4sXOqh-_Hi-7oteePPI889rzEEI5KzlT1cd1yVXVFNywphSMyZIxpnR594zM_jeek1m-lYUyjB2R45TWjHFhlHxJjrhouNJVPSPXv-niJoYhpDAghbGlX_wU3E0Y2-ihp-df5xmACG7C6B9g8mGkoaPfIXm8DukDBbrcDjDSyxR6mJB2OY0uYJxglRPo-x8b8OPpK_Kigz7h68N5Qn59_vRzsSyuvl1cLuZXhZON0gUiNGiYNJw3IDpXGSHqTspVXk-0K6k0ai0AZdXVUMuW1w6YM7rBtm64NPKEvNvnbmL4s8U02cEnh30PI4ZtsrXUMkvQGTR70MWQUsTObqIfIN5bzuxOsl3bnUu7c2l3ku0_yfYuj745vLFdDdg-Dh6sZuDtAYDkoO8ijM6nR07lVbmoMne25259j_dP_oCdLy9yIf8C3wSWTw</recordid><startdate>200307</startdate><enddate>200307</enddate><creator>Maca‐Meyer, N.</creator><creator>Sánchez‐Velasco, P.</creator><creator>Flores, C.</creator><creator>Larruga, J.‐M.</creator><creator>González, A.‐M.</creator><creator>Oterino, A.</creator><creator>Leyva‐Cobián, F.</creator><general>Blackwell Science Ltd</general><general>Cambridge University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200307</creationdate><title>Y Chromosome and Mitochondrial DNA Characterization of Pasiegos, a Human Isolate from Cantabria (Spain)</title><author>Maca‐Meyer, N. ; Sánchez‐Velasco, P. ; Flores, C. ; Larruga, J.‐M. ; González, A.‐M. ; Oterino, A. ; Leyva‐Cobián, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3945-eea9e8038119a2fc68227f33b0452db345e552ae36f7a73d17ca0c859ed791383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Chromosomes, Human, Y - genetics</topic><topic>DNA, Mitochondrial - genetics</topic><topic>General aspects. Genetic counseling</topic><topic>Genetics, Population</topic><topic>Geography</topic><topic>Haplotypes - genetics</topic><topic>Humans</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>mtDNA</topic><topic>Pasiegos</topic><topic>Phylogeny</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Population Dynamics</topic><topic>Sequence Analysis, DNA</topic><topic>Spain</topic><topic>Y‐Chromosome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maca‐Meyer, N.</creatorcontrib><creatorcontrib>Sánchez‐Velasco, P.</creatorcontrib><creatorcontrib>Flores, C.</creatorcontrib><creatorcontrib>Larruga, J.‐M.</creatorcontrib><creatorcontrib>González, A.‐M.</creatorcontrib><creatorcontrib>Oterino, A.</creatorcontrib><creatorcontrib>Leyva‐Cobián, F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maca‐Meyer, N.</au><au>Sánchez‐Velasco, P.</au><au>Flores, C.</au><au>Larruga, J.‐M.</au><au>González, A.‐M.</au><au>Oterino, A.</au><au>Leyva‐Cobián, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Y Chromosome and Mitochondrial DNA Characterization of Pasiegos, a Human Isolate from Cantabria (Spain)</atitle><jtitle>Annals of human genetics</jtitle><addtitle>Ann Hum Genet</addtitle><date>2003-07</date><risdate>2003</risdate><volume>67</volume><issue>4</issue><spage>329</spage><epage>339</epage><pages>329-339</pages><issn>0003-4800</issn><eissn>1469-1809</eissn><coden>ANHGAA</coden><abstract>Summary
Mitochondrial DNA sequences and Y chromosome haplotypes were characterized in Pasiegos, a human isolate from Cantabria, and compared with those of other Cantabrian and neighbouring Northern Spain populations. Cantabria appears to be a genetically heterogeneous community. Whereas Lebaniegos do not differ from their eastern Basque and western Asturian and Galician neighbours, Pasiegos and other non‐Lebaniego Cantabrians show significant differences with all of them. Pasiegos are peculiar for their high frequencies of Y chromosomal markers (E‐M81) with North African assignation, and Y chromosomal (R‐SRY2627) and mtDNA (V, I, U5) markers related to northern European populations. This dual geographic contribution is more in agreement with the complex demographic history of this isolate, as opposed to recent drift effects. The high incidence in Cantabrians with pre‐V and V mtDNA haplotypes, considered as a signal of Postglacial recolonization in Europe from south‐western refugees, points to such refugees as a better candidate population than Basques for this expansion. However, this does not discount a conjoint recolonization.</abstract><cop>9600 Garsington Road , Oxford OX4 2DQ , UK , tel +44 1865 776868 , fax +44 1865 714591</cop><pub>Blackwell Science Ltd</pub><pmid>12914567</pmid><doi>10.1046/j.1469-1809.2003.00045.x</doi><tpages>11</tpages></addata></record> |
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| subjects | Biological and medical sciences Chromosomes, Human, Y - genetics DNA, Mitochondrial - genetics General aspects. Genetic counseling Genetics, Population Geography Haplotypes - genetics Humans Medical genetics Medical sciences mtDNA Pasiegos Phylogeny Polymorphism, Genetic - genetics Polymorphism, Restriction Fragment Length Population Dynamics Sequence Analysis, DNA Spain Y‐Chromosome |
| title | Y Chromosome and Mitochondrial DNA Characterization of Pasiegos, a Human Isolate from Cantabria (Spain) |
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