Fmoc Solid-Phase Synthesis of Peptide Thioesters by Masking as Trithioortho Esters
Total chemical synthesis of proteins by chemoselective ligation relies on C-terminal peptide thioesters as building blocks. Their preparation by standard Fmoc solid-phase peptide synthesis is made difficult by the lability of thioesters to aminolysis by the secondary amines used for removal of the F...
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| Veröffentlicht in: | Organic letters 2003-08, Vol.5 (16), p.2951-2953 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
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