Studies on the enzymatic reduction of N-Boc-4S-amino-3-oxo-5-phenylpentanoic acid methylester

The enzymatic reduction of N-Boc-4S-amino-3-oxo-5-phenylpentanoic acid methylester, the key intermediate in the stereoselective synthesis of a statinanalogue, was studied with Hansenula anomala and Hansenula silvicola. Using whole cells of H. anomala gives complete conversion and a diastereomeric ex...

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Veröffentlicht in:	Journal of biotechnology 1992-11, Vol.26 (2), p.183-201
Hauptverfasser:	Nassenstein, Annette, Hemberger, Jürgen, Schwartz, Harry, Kula, Maria-Regina
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acids Amino Acids - biosynthesis Amino Acids - chemistry amino compounds Biological and medical sciences Biotechnology Chemical industry. Chemical engineering enzyme activity Fundamental and applied biological sciences. Psychology Hansenula Hansenula anomala Hansenula silvicola Industrial applications and implications. Economical aspects Microbial reduction of β-ketoesters N-Boc-4S-amino-3-oxo-5-phenylpentanoic acid methylester NADP (coenzyme) Oxidation-Reduction Oxido reductase oxidoreductases Oxidoreductases - chemistry Oxidoreductases - isolation & purification Oxidoreductases - physiology Pichia - chemistry Pichia - enzymology Pichia - metabolism reduction statine stereochemistry Substrate Specificity yeasts
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