Transduction of the liver with activated Akt normalizes portal pressure in cirrhotic rats

Portal hypertension in cirrhosis is secondary to an increase in hepatic resistance that occurs mainly through collagen deposition. However, recent evidence points to a major contribution by other factors, such as an intrahepatic reduction in nitric oxide production. Akt is a major activator of the e...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2003-08, Vol.125 (2), p.522-531
Hauptverfasser:	Morales-ruiz, Manuel, Cejudo-martı́n, Pilar, Fernández-varo, Guillermo, Tugues, Sònia, Ros, Josefa, Angeli, Paolo, Rivera, Francisca, Arroyo, Vicente, Rodés, Juan, Sessa, William C, Jiménez, Wladimiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Genetic Therapy Hemodynamics Hypertension, Portal - etiology Hypertension, Portal - therapy Liver - metabolism Liver Cirrhosis, Experimental - complications Male Medical sciences Nitric Oxide - biosynthesis Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-akt Rats Rats, Wistar Transduction, Genetic Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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