Isolation and Antihypertensive Effect of Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Spinach Rubisco

Four new inhibitory peptides for angiotensin I-converting enzyme (ACE), that is, MRWRD, MRW, LRIPVA, and IAYKPAG, were isolated from the pepsin−pancreatin digest of spinach Rubisco with the use of HPLC. IC50 values of individual peptides were 2.1, 0.6, 0.38, and 4.2 μM, respectively. MRW and MRWRD h...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2003-08, Vol.51 (17), p.4897-4902
Hauptverfasser:	Yang, Yanjun, Marczak, Ewa D, Yokoo, Megumi, Usui, Hachiro, Yoshikawa, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Angiotensin-Converting Enzyme Inhibitors - isolation & purification Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals antihypertensive effect Chromatography, High Pressure Liquid high performance liquid chromatography Hypertension - drug therapy Male oral administration Pancreatin - metabolism Pepsin A - metabolism Peptide Fragments - chemistry Peptide Fragments - isolation & purification Peptide Fragments - therapeutic use peptides peptidyl-dipeptidase A Rats Rats, Inbred SHR ribulose-bisphosphate carboxylase Ribulose-Bisphosphate Carboxylase - chemistry spinach Spinacia oleracea - chemistry Spinacia oleracea - enzymology
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