Synthesis of amide compounds of ferulic acid, and their stimulatory effects on insulin secretion in vitro

We prepared amide compounds which were derived from ferulic acid using various amines, and investigated their stimulatory effects on insulin secretion using rat pancreatic RIN-5F cells. Most of these compounds exhibited significant promotion of the insulin-release at a concentration of 10 μM and in...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic & medicinal chemistry 2003-08, Vol.11 (17), p.3807-3813
Hauptverfasser:	Nomura, Eisaku, Kashiwada, Ayumi, Hosoda, Asao, Nakamura, Kozo, Morishita, Hideko, Tsuno, Takuo, Taniguchi, Hisaji
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - pharmacology Animals Biological and medical sciences Cell Survival Coumaric Acids - chemical synthesis Coumaric Acids - chemistry Coumaric Acids - pharmacology Dose-Response Relationship, Drug General and cellular metabolism. Vitamins Insulin - biosynthesis Medical sciences Pharmacology. Drug treatments Rats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!