An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice

The t(8;21)(q22;q22) translocation, occurring in 40% of patients with acute myeloid leukemia (AML) of the FAB-M2 subtype (AML with maturation), results in expression of the RUNX1-CBF2T1 [AML1-ETO (AE)] fusion oncogene. AML/ETO may contribute to leukemogenesis by interacting with nuclear corepressor...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-08, Vol.100 (16), p.9506-9511
Hauptverfasser:	Grisolano, Jay L, O'Neal, Julie, Cain, Jennifer, Tomasson, Michael H
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Acetylation Animals Benzamides Blotting, Southern Bone Marrow Transplantation Core Binding Factor Alpha 2 Subunit DNA - metabolism Flow Cytometry Gene expression Histone Deacetylases - metabolism Histones - metabolism Humans Hydroxamic Acids - pharmacology Imatinib Mesylate Laboratory animals Leukemia Leukemia, Myeloid, Acute - etiology Leukemia, Myeloid, Acute - metabolism Medical research Mice Mice, Inbred BALB C Mice, Transgenic Models, Genetic Mutation Oncogene Proteins, Fusion - metabolism Oncogene Proteins, Fusion - physiology Phenotype Piperazines - pharmacology Plasmids - metabolism Protein Binding Protein Structure, Tertiary Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins c-kit - biosynthesis Pyrimidines - pharmacology Retroviridae - genetics RUNX1 Translocation Partner 1 Protein Time Factors Transcription Factors - metabolism Transcription Factors - physiology Vorinostat
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