Deficiency of interleukin-1 receptor antagonist promotes neointimal formation after injury

The cytokine interleukin (IL)-1 is an important mediator of inflammation and cardiovascular disease. Activity of this cytokine is modulated endogenously via the IL-1 receptor antagonist (IL-1Ra). The role of IL-1Ra in neointima formation after injury, however, is poorly understood. Using IL-1Ra-defi...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2003-08, Vol.108 (5), p.516-518
Hauptverfasser:	Isoda, Kikuo, Shiigai, Masaru, Ishigami, Norio, Matsuki, Taizo, Horai, Reiko, Nishikawa, Kenichirou, Kusuhara, Masatoshi, Nishida, Yasuhiro, Iwakura, Yoichiro, Ohsuzu, Fumitaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division - genetics Disease Models, Animal Disease Progression Femoral Artery - injuries Femoral Artery - metabolism Femoral Artery - pathology Genetic Predisposition to Disease Homozygote Hyperplasia - pathology Immunohistochemistry Interleukin 1 Receptor Antagonist Protein Interleukin-1 - biosynthesis Mice Mice, Inbred C57BL Mice, Mutant Strains Phenotype Proliferating Cell Nuclear Antigen - biosynthesis Sialoglycoproteins - biosynthesis Sialoglycoproteins - deficiency Sialoglycoproteins - genetics Tunica Intima - injuries Tunica Intima - metabolism Tunica Intima - pathology
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