Anti-analgesic activity of enterostatin (VPDPR) is mediated by corticosterone

Although enterostatin (VPDPR) inhibited morphine-induced analgesia, it had no affinity for μ-opioid receptors. VPDPR administration was reported to elevate serum corticosterone levels. We found that corticosterone exhibited a similar anti-analgesic effect selective for μ-opioid. Furthermore, the ant...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2003-05, Vol.24 (5), p.735-739
Hauptverfasser:	Takenaka, Y., Nakamura, F., Usui, H., Lipkowski, A.W., Toth, G., Yoshikawa, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenalectomy Analgesics, Opioid - antagonists & inhibitors Animals Anti-analgesic effect Binding, Competitive Biological and medical sciences Corticosterone Corticosterone - pharmacology Dietary Fats - administration & dosage Dietary Fats - pharmacology Enterostratin Fundamental and applied biological sciences. Psychology Male Mice Mifepristone - metabolism Morphine - antagonists & inhibitors Oligopeptides - metabolism Oligopeptides - pharmacology Receptors, Opioid, kappa - antagonists & inhibitors Receptors, Opioid, kappa - metabolism Receptors, Opioid, mu - antagonists & inhibitors Receptors, Opioid, mu - metabolism RU486 Vertebrates: endocrinology μ-Opioid
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