Anti-analgesic activity of enterostatin (VPDPR) is mediated by corticosterone
Although enterostatin (VPDPR) inhibited morphine-induced analgesia, it had no affinity for μ-opioid receptors. VPDPR administration was reported to elevate serum corticosterone levels. We found that corticosterone exhibited a similar anti-analgesic effect selective for μ-opioid. Furthermore, the ant...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2003-05, Vol.24 (5), p.735-739 |
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| container_title | Peptides (New York, N.Y. : 1980) |
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| creator | Takenaka, Y. Nakamura, F. Usui, H. Lipkowski, A.W. Toth, G. Yoshikawa, M. |
| description | Although enterostatin (VPDPR) inhibited morphine-induced analgesia, it had no affinity for μ-opioid receptors. VPDPR administration was reported to elevate serum corticosterone levels. We found that corticosterone exhibited a similar anti-analgesic effect selective for μ-opioid. Furthermore, the anti-analgesic effect of VPDPR was inhibited by RU486, an antagonist for the glucocorticoid receptor. The anti-analgesic effect of VPDPR was not observed in adrenalectomized mice. These results suggest that the anti-analgesic activity of VPDPR is mediated by corticosterone released from the adrenal cortex. |
| doi_str_mv | 10.1016/S0196-9781(03)00124-4 |
| format | Article |
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VPDPR administration was reported to elevate serum corticosterone levels. We found that corticosterone exhibited a similar anti-analgesic effect selective for μ-opioid. Furthermore, the anti-analgesic effect of VPDPR was inhibited by RU486, an antagonist for the glucocorticoid receptor. The anti-analgesic effect of VPDPR was not observed in adrenalectomized mice. These results suggest that the anti-analgesic activity of VPDPR is mediated by corticosterone released from the adrenal cortex.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/S0196-9781(03)00124-4</identifier><identifier>PMID: 12895660</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adrenalectomy ; Analgesics, Opioid - antagonists & inhibitors ; Animals ; Anti-analgesic effect ; Binding, Competitive ; Biological and medical sciences ; Corticosterone ; Corticosterone - pharmacology ; Dietary Fats - administration & dosage ; Dietary Fats - pharmacology ; Enterostratin ; Fundamental and applied biological sciences. Psychology ; Male ; Mice ; Mifepristone - metabolism ; Morphine - antagonists & inhibitors ; Oligopeptides - metabolism ; Oligopeptides - pharmacology ; Receptors, Opioid, kappa - antagonists & inhibitors ; Receptors, Opioid, kappa - metabolism ; Receptors, Opioid, mu - antagonists & inhibitors ; Receptors, Opioid, mu - metabolism ; RU486 ; Vertebrates: endocrinology ; μ-Opioid</subject><ispartof>Peptides (New York, N.Y. : 1980), 2003-05, Vol.24 (5), p.735-739</ispartof><rights>2003 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-772d5de6746f4958aad5a01dd63bbe34653e4d1a5b19f7606749b4f238de48543</citedby><cites>FETCH-LOGICAL-c457t-772d5de6746f4958aad5a01dd63bbe34653e4d1a5b19f7606749b4f238de48543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0196978103001244$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15064943$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12895660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takenaka, Y.</creatorcontrib><creatorcontrib>Nakamura, F.</creatorcontrib><creatorcontrib>Usui, H.</creatorcontrib><creatorcontrib>Lipkowski, A.W.</creatorcontrib><creatorcontrib>Toth, G.</creatorcontrib><creatorcontrib>Yoshikawa, M.</creatorcontrib><title>Anti-analgesic activity of enterostatin (VPDPR) is mediated by corticosterone</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>Although enterostatin (VPDPR) inhibited morphine-induced analgesia, it had no affinity for μ-opioid receptors. VPDPR administration was reported to elevate serum corticosterone levels. We found that corticosterone exhibited a similar anti-analgesic effect selective for μ-opioid. Furthermore, the anti-analgesic effect of VPDPR was inhibited by RU486, an antagonist for the glucocorticoid receptor. The anti-analgesic effect of VPDPR was not observed in adrenalectomized mice. These results suggest that the anti-analgesic activity of VPDPR is mediated by corticosterone released from the adrenal cortex.</description><subject>Adrenalectomy</subject><subject>Analgesics, Opioid - antagonists & inhibitors</subject><subject>Animals</subject><subject>Anti-analgesic effect</subject><subject>Binding, Competitive</subject><subject>Biological and medical sciences</subject><subject>Corticosterone</subject><subject>Corticosterone - pharmacology</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fats - pharmacology</subject><subject>Enterostratin</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Mice</subject><subject>Mifepristone - metabolism</subject><subject>Morphine - antagonists & inhibitors</subject><subject>Oligopeptides - metabolism</subject><subject>Oligopeptides - pharmacology</subject><subject>Receptors, Opioid, kappa - antagonists & inhibitors</subject><subject>Receptors, Opioid, kappa - metabolism</subject><subject>Receptors, Opioid, mu - antagonists & inhibitors</subject><subject>Receptors, Opioid, mu - metabolism</subject><subject>RU486</subject><subject>Vertebrates: endocrinology</subject><subject>μ-Opioid</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MtOxCAUgGFiNDpeHkHTjUYXVSi3sjLGe6LReNsSCqcG02lHYEzm7WWciS5dsfngcH6Edgk-JpiIk2dMlCiVrMkhpkcYk4qVbAWNSC1pyYlQq2j0SzbQZowfGGPGVL2ONkhVKy4EHqH7sz750vSme4fobWFs8l8-zYqhLaBPEIaYTPJ9cfj2ePH4dFT4WIzBeZPAFc2ssENI3maUZQ_baK01XYSd5bmFXq8uX85vyruH69vzs7vSMi5TKWXluAMhmWiZ4rUxjhtMnBO0aYAywSkwRwxviGqlwBmqhrUVrR2wmjO6hQ4W707C8DmFmPTYRwtdZ3oYplFLyitJ6ipDvoA2LxIDtHoS_NiEmSZYzzvqn456Hkljqn866vmAveWAaZPX_bu1DJfB_hKYaE3XBtNbH_8cx4IpRrM7XTjIOb48BB2th97mhAFs0m7w_3zlG58fjm0</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Takenaka, Y.</creator><creator>Nakamura, F.</creator><creator>Usui, H.</creator><creator>Lipkowski, A.W.</creator><creator>Toth, G.</creator><creator>Yoshikawa, M.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>Anti-analgesic activity of enterostatin (VPDPR) is mediated by corticosterone</title><author>Takenaka, Y. ; Nakamura, F. ; Usui, H. ; Lipkowski, A.W. ; Toth, G. ; Yoshikawa, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-772d5de6746f4958aad5a01dd63bbe34653e4d1a5b19f7606749b4f238de48543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adrenalectomy</topic><topic>Analgesics, Opioid - antagonists & inhibitors</topic><topic>Animals</topic><topic>Anti-analgesic effect</topic><topic>Binding, Competitive</topic><topic>Biological and medical sciences</topic><topic>Corticosterone</topic><topic>Corticosterone - pharmacology</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fats - pharmacology</topic><topic>Enterostratin</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Mice</topic><topic>Mifepristone - metabolism</topic><topic>Morphine - antagonists & inhibitors</topic><topic>Oligopeptides - metabolism</topic><topic>Oligopeptides - pharmacology</topic><topic>Receptors, Opioid, kappa - antagonists & inhibitors</topic><topic>Receptors, Opioid, kappa - metabolism</topic><topic>Receptors, Opioid, mu - antagonists & inhibitors</topic><topic>Receptors, Opioid, mu - metabolism</topic><topic>RU486</topic><topic>Vertebrates: endocrinology</topic><topic>μ-Opioid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takenaka, Y.</creatorcontrib><creatorcontrib>Nakamura, F.</creatorcontrib><creatorcontrib>Usui, H.</creatorcontrib><creatorcontrib>Lipkowski, A.W.</creatorcontrib><creatorcontrib>Toth, G.</creatorcontrib><creatorcontrib>Yoshikawa, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takenaka, Y.</au><au>Nakamura, F.</au><au>Usui, H.</au><au>Lipkowski, A.W.</au><au>Toth, G.</au><au>Yoshikawa, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-analgesic activity of enterostatin (VPDPR) is mediated by corticosterone</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>24</volume><issue>5</issue><spage>735</spage><epage>739</epage><pages>735-739</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>Although enterostatin (VPDPR) inhibited morphine-induced analgesia, it had no affinity for μ-opioid receptors. VPDPR administration was reported to elevate serum corticosterone levels. We found that corticosterone exhibited a similar anti-analgesic effect selective for μ-opioid. Furthermore, the anti-analgesic effect of VPDPR was inhibited by RU486, an antagonist for the glucocorticoid receptor. The anti-analgesic effect of VPDPR was not observed in adrenalectomized mice. These results suggest that the anti-analgesic activity of VPDPR is mediated by corticosterone released from the adrenal cortex.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12895660</pmid><doi>10.1016/S0196-9781(03)00124-4</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 2003-05, Vol.24 (5), p.735-739 |
| issn | 0196-9781 1873-5169 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adrenalectomy Analgesics, Opioid - antagonists & inhibitors Animals Anti-analgesic effect Binding, Competitive Biological and medical sciences Corticosterone Corticosterone - pharmacology Dietary Fats - administration & dosage Dietary Fats - pharmacology Enterostratin Fundamental and applied biological sciences. Psychology Male Mice Mifepristone - metabolism Morphine - antagonists & inhibitors Oligopeptides - metabolism Oligopeptides - pharmacology Receptors, Opioid, kappa - antagonists & inhibitors Receptors, Opioid, kappa - metabolism Receptors, Opioid, mu - antagonists & inhibitors Receptors, Opioid, mu - metabolism RU486 Vertebrates: endocrinology μ-Opioid |
| title | Anti-analgesic activity of enterostatin (VPDPR) is mediated by corticosterone |
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