Heterogeneity of glutathione S-transferase enzyme and gene expression in ovarian carcinoma

Expression of the three major cytosolic classes of glutathione S-transferases (GST; Pi, Alpha and Mu) was examined by 2D gel analysis and Western blotting of biopsies from 26 patients diagnosed with ovarian carcinoma. In contrast to other tissues, at least one 'constitutive' subunit from e...

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Veröffentlicht in:	Pharmacogenetics (London) 1992-04, Vol.2 (2), p.63-72
Hauptverfasser:	Schisselbauer, J C, Hogan, W M, Buetow, K H, Tew, K D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Blotting, Southern Cytosol - enzymology DNA, Neoplasm - genetics Female Gene Expression Regulation, Neoplastic Glutathione Transferase - genetics Glutathione Transferase - isolation & purification Glutathione Transferase - metabolism Humans Isoenzymes - genetics Isoenzymes - isolation & purification Isoenzymes - metabolism Middle Aged Ovarian Neoplasms - enzymology Ovarian Neoplasms - genetics Polymorphism, Restriction Fragment Length
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