Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3
Genetic linkage studies with chromosome 21 DNA markers and mutation analysis of the β–amyloid protein precursor gene located in 21q21.3 have indicated that early–onset Alzheimer's disease (EOAD) is a heterogeneous disorder for which at least one other chromosomal locus exists. We examined two e...
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| Veröffentlicht in: | Nature genetics 1992-12, Vol.2 (4), p.335-339 |
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| creator | Van Broeckhoven, Christine Backhovens, Hubert Cruts, Marc De Winter, Goedele Bruyland, Marc Cras, Patrick Martin, Jean-Jacques |
| description | Genetic linkage studies with chromosome 21 DNA markers and mutation analysis of the β–amyloid protein precursor gene located in 21q21.3 have indicated that early–onset Alzheimer's disease (EOAD) is a heterogeneous disorder for which at least one other chromosomal locus exists. We examined two extended histopathologically confirmed EOAD pedigrees, AD/A and AD/B, with highly informative short tandem repeat (STR) polymorphisms and found complete linkage of the disease to a (CA)
n
dinucleotide repeat polymorphism at locus
D14S43
in 14q24.3 (Z
max
= 13.25 at θ = 0.0). Using additional chromosome 14 STR polymorphisms we were able to delineate the region containing the EOAD gene to an area of, at most, 8.9 centiMorgans between
D14S42
and
D14S53
, flanking
D14S43
on both sides. |
| doi_str_mv | 10.1038/ng1292-335 |
| format | Article |
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n
dinucleotide repeat polymorphism at locus
D14S43
in 14q24.3 (Z
max
= 13.25 at θ = 0.0). Using additional chromosome 14 STR polymorphisms we were able to delineate the region containing the EOAD gene to an area of, at most, 8.9 centiMorgans between
D14S42
and
D14S53
, flanking
D14S43
on both sides.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng1292-335</identifier><identifier>PMID: 1303290</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adult ; Agriculture ; Alzheimer Disease - genetics ; Alzheimer's disease ; Animal Genetics and Genomics ; Base Sequence ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; chromosome 14 ; Chromosome Mapping ; Chromosomes, Human, Pair 14 ; Chromosomes, Human, Pair 21 ; DNA - genetics ; Female ; Gene Function ; gene mapping ; genes ; Genetic Markers ; Human Genetics ; Humans ; Lod Score ; Male ; man ; Pedigree ; Polymorphism, Genetic ; Repetitive Sequences, Nucleic Acid</subject><ispartof>Nature genetics, 1992-12, Vol.2 (4), p.335-339</ispartof><rights>Springer Nature America, Inc. 1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-61979b77dd0e2c2742b36ab9492e02a65ee857c718c25a7aa28c3ada9451f0553</citedby><cites>FETCH-LOGICAL-c475t-61979b77dd0e2c2742b36ab9492e02a65ee857c718c25a7aa28c3ada9451f0553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ng1292-335$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ng1292-335$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1303290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Broeckhoven, Christine</creatorcontrib><creatorcontrib>Backhovens, Hubert</creatorcontrib><creatorcontrib>Cruts, Marc</creatorcontrib><creatorcontrib>De Winter, Goedele</creatorcontrib><creatorcontrib>Bruyland, Marc</creatorcontrib><creatorcontrib>Cras, Patrick</creatorcontrib><creatorcontrib>Martin, Jean-Jacques</creatorcontrib><title>Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>Genetic linkage studies with chromosome 21 DNA markers and mutation analysis of the β–amyloid protein precursor gene located in 21q21.3 have indicated that early–onset Alzheimer's disease (EOAD) is a heterogeneous disorder for which at least one other chromosomal locus exists. We examined two extended histopathologically confirmed EOAD pedigrees, AD/A and AD/B, with highly informative short tandem repeat (STR) polymorphisms and found complete linkage of the disease to a (CA)
n
dinucleotide repeat polymorphism at locus
D14S43
in 14q24.3 (Z
max
= 13.25 at θ = 0.0). Using additional chromosome 14 STR polymorphisms we were able to delineate the region containing the EOAD gene to an area of, at most, 8.9 centiMorgans between
D14S42
and
D14S53
, flanking
D14S43
on both sides.</description><subject>Adult</subject><subject>Agriculture</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer's disease</subject><subject>Animal Genetics and Genomics</subject><subject>Base Sequence</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>chromosome 14</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 14</subject><subject>Chromosomes, Human, Pair 21</subject><subject>DNA - genetics</subject><subject>Female</subject><subject>Gene Function</subject><subject>gene mapping</subject><subject>genes</subject><subject>Genetic Markers</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Lod Score</subject><subject>Male</subject><subject>man</subject><subject>Pedigree</subject><subject>Polymorphism, Genetic</subject><subject>Repetitive Sequences, Nucleic Acid</subject><issn>1061-4036</issn><issn>1546-1718</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctKw0AUhgdRqlY37oWsFJTUuU9mWYo3qLjRhaswTU7blCSTziSLuvIdfEOfxCkpuBF0NYf5Pz4450fojOARwSy5qReEahozJvbQERFcxkSRZD_MWJKYYyYP0bH3K4wJ5zgZoAFhmFGNj9Dbk2maol5Edh6ZaAE1RI2DvPCN9dvv1kZgXLn5-vi0tYc2GpfvSygqcJc-ChgYD1soWzpbWW8riAhfUz5iJ-hgbkoPp7t3iF7vbl8mD_H0-f5xMp7GGVeijSXRSs-UynMMNKOK0xmTZqa5poCpkQIgESoL-2RUGGUMTTJmcqO5IHMsBBuii97bOLvuwLdpVfgMytLUYDufKiaoTKT-EyRSaMxU8g-QE6nF1njVg5mz3juYp40rKuM2KcHptpm0byYNzQT4fGftZhXkP2hfRciv-9yHpF6AS1e2c3U43W-2b7V2lhY</recordid><startdate>19921201</startdate><enddate>19921201</enddate><creator>Van Broeckhoven, Christine</creator><creator>Backhovens, Hubert</creator><creator>Cruts, Marc</creator><creator>De Winter, Goedele</creator><creator>Bruyland, Marc</creator><creator>Cras, Patrick</creator><creator>Martin, Jean-Jacques</creator><general>Nature Publishing Group US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T3</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19921201</creationdate><title>Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3</title><author>Van Broeckhoven, Christine ; Backhovens, Hubert ; Cruts, Marc ; De Winter, Goedele ; Bruyland, Marc ; Cras, Patrick ; Martin, Jean-Jacques</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-61979b77dd0e2c2742b36ab9492e02a65ee857c718c25a7aa28c3ada9451f0553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Agriculture</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer's disease</topic><topic>Animal Genetics and Genomics</topic><topic>Base Sequence</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>chromosome 14</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 14</topic><topic>Chromosomes, Human, Pair 21</topic><topic>DNA - genetics</topic><topic>Female</topic><topic>Gene Function</topic><topic>gene mapping</topic><topic>genes</topic><topic>Genetic Markers</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Lod Score</topic><topic>Male</topic><topic>man</topic><topic>Pedigree</topic><topic>Polymorphism, Genetic</topic><topic>Repetitive Sequences, Nucleic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Broeckhoven, Christine</creatorcontrib><creatorcontrib>Backhovens, Hubert</creatorcontrib><creatorcontrib>Cruts, Marc</creatorcontrib><creatorcontrib>De Winter, Goedele</creatorcontrib><creatorcontrib>Bruyland, Marc</creatorcontrib><creatorcontrib>Cras, Patrick</creatorcontrib><creatorcontrib>Martin, Jean-Jacques</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Human Genome Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Broeckhoven, Christine</au><au>Backhovens, Hubert</au><au>Cruts, Marc</au><au>De Winter, Goedele</au><au>Bruyland, Marc</au><au>Cras, Patrick</au><au>Martin, Jean-Jacques</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>1992-12-01</date><risdate>1992</risdate><volume>2</volume><issue>4</issue><spage>335</spage><epage>339</epage><pages>335-339</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><abstract>Genetic linkage studies with chromosome 21 DNA markers and mutation analysis of the β–amyloid protein precursor gene located in 21q21.3 have indicated that early–onset Alzheimer's disease (EOAD) is a heterogeneous disorder for which at least one other chromosomal locus exists. We examined two extended histopathologically confirmed EOAD pedigrees, AD/A and AD/B, with highly informative short tandem repeat (STR) polymorphisms and found complete linkage of the disease to a (CA)
n
dinucleotide repeat polymorphism at locus
D14S43
in 14q24.3 (Z
max
= 13.25 at θ = 0.0). Using additional chromosome 14 STR polymorphisms we were able to delineate the region containing the EOAD gene to an area of, at most, 8.9 centiMorgans between
D14S42
and
D14S53
, flanking
D14S43
on both sides.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>1303290</pmid><doi>10.1038/ng1292-335</doi><tpages>5</tpages></addata></record> |
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| ispartof | Nature genetics, 1992-12, Vol.2 (4), p.335-339 |
| issn | 1061-4036 1546-1718 |
| language | eng |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Adult Agriculture Alzheimer Disease - genetics Alzheimer's disease Animal Genetics and Genomics Base Sequence Biomedical and Life Sciences Biomedicine Cancer Research chromosome 14 Chromosome Mapping Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 21 DNA - genetics Female Gene Function gene mapping genes Genetic Markers Human Genetics Humans Lod Score Male man Pedigree Polymorphism, Genetic Repetitive Sequences, Nucleic Acid |
| title | Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3 |
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