Prevention of Collagen-Induced Arthritis in Mice Transgenic for the Complement Inhibitor Complement Receptor 1-Related Gene/Protein y

The objective of these studies was to examine collagen-induced arthritis (CIA) in C57BL/6 mice transgenic for the rodent complement regulatory protein complement receptor 1-related gene/protein y (Crry) (Crry-Tg), a C3 convertase inhibitor. The scores for clinical disease activity and for histologic...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-08, Vol.171 (4), p.2109-2115
Hauptverfasser:	Banda, Nirmal K, Kraus, Damian M, Muggli, Michele, Bendele, Alison, Holers, V. Michael, Arend, William P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Experimental - genetics Arthritis, Experimental - immunology Arthritis, Experimental - pathology Arthritis, Experimental - prevention & control Autoantibodies - biosynthesis Autoantibodies - blood Cattle Collagen Type II - administration & dosage Collagen Type II - immunology Complement Inactivator Proteins - genetics Cytokines - biosynthesis Female Hindlimb Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunohistochemistry Injections, Intradermal Lymph Nodes - cytology Lymph Nodes - immunology Lymphocyte Activation - genetics Lymphocyte Subsets - immunology Male Mice Mice, Inbred C57BL Mice, Transgenic Receptors, Complement - biosynthesis Receptors, Complement - genetics Receptors, Complement 3b - genetics RNA, Messenger - analysis Spleen - cytology Spleen - immunology Spleen - metabolism
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