The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced and excluded as susceptibility gene for diabetic nephropathy
Diabetic nephropathy (DN) is the most common cause of renal failure in the western hemisphere. Epidemiological studies have suggested a genetic susceptibility for DN. Linkage analysis showed evidence for a locus on chromosome 18q22.3-q23 in Turkish families. We report the construction of a transcrip...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 2003-09, Vol.82 (3), p.406-411 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | Halama, Niels Yard-Breedijk, Annette Vardarli, Irfan Akkoyun, Imren Yard, Benito Janssen, Bart van der Woude, Fokko J |
| description | Diabetic nephropathy (DN) is the most common cause of renal failure in the western hemisphere. Epidemiological studies have suggested a genetic susceptibility for DN. Linkage analysis showed evidence for a locus on chromosome 18q22.3-q23 in Turkish families. We report the construction of a transcript map of the target region on chromosome 18q22.3-q23 and analysis of the candidate gene
ZNF236. By using recent publications, human genome databases, and a multitude of available protein-predicting programs, we obtained a detailed map of this 4.7-Mb-spanning region. We sequenced
ZNF236 in patients with diabetic nephropathy and diabetes without nephropathy, as well as in unaffected controls. We observed multiple splice forms in all individuals but no mutation in any of the patients. It seems improbable, therefore, that
ZNF236 is a gene that confers DN susceptibility. |
| doi_str_mv | 10.1016/S0888-7543(03)00120-4 |
| format | Article |
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ZNF236. By using recent publications, human genome databases, and a multitude of available protein-predicting programs, we obtained a detailed map of this 4.7-Mb-spanning region. We sequenced
ZNF236 in patients with diabetic nephropathy and diabetes without nephropathy, as well as in unaffected controls. We observed multiple splice forms in all individuals but no mutation in any of the patients. It seems improbable, therefore, that
ZNF236 is a gene that confers DN susceptibility.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1016/S0888-7543(03)00120-4</identifier><identifier>PMID: 12906866</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Alternative Splicing ; Amino Acid Sequence ; Biochemistry. Physiology. Immunology. Molecular biology ; Biological and medical sciences ; Carrier Proteins - genetics ; Chromosome 18 ; Chromosome Mapping ; Chromosomes, Human, Pair 18 ; Diabetic Nephropathies - genetics ; Diabetic nephropathy ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; Humans ; Molecular Sequence Data ; Protozoa ; Sequence analysis ; Sequence Analysis, DNA ; Transcription Factors - genetics ; Zinc-finger ; ZNF236</subject><ispartof>Genomics (San Diego, Calif.), 2003-09, Vol.82 (3), p.406-411</ispartof><rights>2003 Elsevier Science (USA)</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-da0298d47f8e7286e5e14c9f71bd14b929883ae6842474827e7254d3165ac33</citedby><cites>FETCH-LOGICAL-c422t-da0298d47f8e7286e5e14c9f71bd14b929883ae6842474827e7254d3165ac33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0888-7543(03)00120-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15037065$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12906866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Halama, Niels</creatorcontrib><creatorcontrib>Yard-Breedijk, Annette</creatorcontrib><creatorcontrib>Vardarli, Irfan</creatorcontrib><creatorcontrib>Akkoyun, Imren</creatorcontrib><creatorcontrib>Yard, Benito</creatorcontrib><creatorcontrib>Janssen, Bart</creatorcontrib><creatorcontrib>van der Woude, Fokko J</creatorcontrib><title>The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced and excluded as susceptibility gene for diabetic nephropathy</title><title>Genomics (San Diego, Calif.)</title><addtitle>Genomics</addtitle><description>Diabetic nephropathy (DN) is the most common cause of renal failure in the western hemisphere. Epidemiological studies have suggested a genetic susceptibility for DN. Linkage analysis showed evidence for a locus on chromosome 18q22.3-q23 in Turkish families. We report the construction of a transcript map of the target region on chromosome 18q22.3-q23 and analysis of the candidate gene
ZNF236. By using recent publications, human genome databases, and a multitude of available protein-predicting programs, we obtained a detailed map of this 4.7-Mb-spanning region. We sequenced
ZNF236 in patients with diabetic nephropathy and diabetes without nephropathy, as well as in unaffected controls. We observed multiple splice forms in all individuals but no mutation in any of the patients. It seems improbable, therefore, that
ZNF236 is a gene that confers DN susceptibility.</description><subject>Alternative Splicing</subject><subject>Amino Acid Sequence</subject><subject>Biochemistry. Physiology. Immunology. Molecular biology</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - genetics</subject><subject>Chromosome 18</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 18</subject><subject>Diabetic Nephropathies - genetics</subject><subject>Diabetic nephropathy</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Molecular Sequence Data</subject><subject>Protozoa</subject><subject>Sequence analysis</subject><subject>Sequence Analysis, DNA</subject><subject>Transcription Factors - genetics</subject><subject>Zinc-finger</subject><subject>ZNF236</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhJ4B8AcEhxV9x7BNCFQXUqhzaExfLsSddg9cJdlKxHPjt9bIreqxkybL8zMyreRB6SckJJVS-vyJKqaZrBX9L-DtCKCONeIRWlCjdKCnkY7T6jxyhZ6X8IIRorthTdESZJlJJuUJ_r9eAz_MyTRCbGH4C_hOSa4aQbiDjG0iAv1-eMS5xKNjGGXKyc7iFuMVlisGBxzZ5DL9dXPzuUXBZioNpDn2IYd7uewxjxj7YHubgcIJpncfJzuvtc_RksLHAi8N9jK7OPl2ffmkuvn3-evrxonGCsbnxljCtvOgGBR1TElqgwumho72notf1U3ELUgkmOqFYV6lWeE5lax3nx-jNvuuUx18LlNlsQs0Yo00wLsV0vGWSteRBkCpFtZa6gu0edHksJcNgphw2Nm8NJWbnx_zzY3bLN6SenR8jat2rw4Cl34C_rzoIqcDrA2CLs3HINrlQ7rkasiOyrdyHPQd1a7cBsikuQKo-QgY3Gz-GB6LcAV7drOY</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>Halama, Niels</creator><creator>Yard-Breedijk, Annette</creator><creator>Vardarli, Irfan</creator><creator>Akkoyun, Imren</creator><creator>Yard, Benito</creator><creator>Janssen, Bart</creator><creator>van der Woude, Fokko J</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced and excluded as susceptibility gene for diabetic nephropathy</title><author>Halama, Niels ; Yard-Breedijk, Annette ; Vardarli, Irfan ; Akkoyun, Imren ; Yard, Benito ; Janssen, Bart ; van der Woude, Fokko J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-da0298d47f8e7286e5e14c9f71bd14b929883ae6842474827e7254d3165ac33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Alternative Splicing</topic><topic>Amino Acid Sequence</topic><topic>Biochemistry. Physiology. Immunology. Molecular biology</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - genetics</topic><topic>Chromosome 18</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 18</topic><topic>Diabetic Nephropathies - genetics</topic><topic>Diabetic nephropathy</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Molecular Sequence Data</topic><topic>Protozoa</topic><topic>Sequence analysis</topic><topic>Sequence Analysis, DNA</topic><topic>Transcription Factors - genetics</topic><topic>Zinc-finger</topic><topic>ZNF236</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Halama, Niels</creatorcontrib><creatorcontrib>Yard-Breedijk, Annette</creatorcontrib><creatorcontrib>Vardarli, Irfan</creatorcontrib><creatorcontrib>Akkoyun, Imren</creatorcontrib><creatorcontrib>Yard, Benito</creatorcontrib><creatorcontrib>Janssen, Bart</creatorcontrib><creatorcontrib>van der Woude, Fokko J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Halama, Niels</au><au>Yard-Breedijk, Annette</au><au>Vardarli, Irfan</au><au>Akkoyun, Imren</au><au>Yard, Benito</au><au>Janssen, Bart</au><au>van der Woude, Fokko J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced and excluded as susceptibility gene for diabetic nephropathy</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>82</volume><issue>3</issue><spage>406</spage><epage>411</epage><pages>406-411</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>Diabetic nephropathy (DN) is the most common cause of renal failure in the western hemisphere. Epidemiological studies have suggested a genetic susceptibility for DN. Linkage analysis showed evidence for a locus on chromosome 18q22.3-q23 in Turkish families. We report the construction of a transcript map of the target region on chromosome 18q22.3-q23 and analysis of the candidate gene
ZNF236. By using recent publications, human genome databases, and a multitude of available protein-predicting programs, we obtained a detailed map of this 4.7-Mb-spanning region. We sequenced
ZNF236 in patients with diabetic nephropathy and diabetes without nephropathy, as well as in unaffected controls. We observed multiple splice forms in all individuals but no mutation in any of the patients. It seems improbable, therefore, that
ZNF236 is a gene that confers DN susceptibility.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>12906866</pmid><doi>10.1016/S0888-7543(03)00120-4</doi><tpages>6</tpages></addata></record> |
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| subjects | Alternative Splicing Amino Acid Sequence Biochemistry. Physiology. Immunology. Molecular biology Biological and medical sciences Carrier Proteins - genetics Chromosome 18 Chromosome Mapping Chromosomes, Human, Pair 18 Diabetic Nephropathies - genetics Diabetic nephropathy Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Humans Molecular Sequence Data Protozoa Sequence analysis Sequence Analysis, DNA Transcription Factors - genetics Zinc-finger ZNF236 |
| title | The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced and excluded as susceptibility gene for diabetic nephropathy |
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