Age-related changes in cerebral lactate metabolism in sleep-disordered breathing
Thirty-one patients, aged 22–71 years, with nocturnal apneic episodes and/or habitual snoring were studied with magnetic resonance spectroscopy (MRS) and diagnostic polysomnography separately to determine whether accumulation of lactate caused by cerebral hypoxia during sleep is associated with slee...
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| Veröffentlicht in: | Neurobiology of aging 2003-09, Vol.24 (5), p.753-760 |
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| creator | Kamba, Masayuki Inoue, Yuichi Higami, Shigeru Suto, Yuji |
| description | Thirty-one patients, aged 22–71 years, with nocturnal apneic episodes and/or habitual snoring were studied with magnetic resonance spectroscopy (MRS) and diagnostic polysomnography separately to determine whether accumulation of lactate caused by cerebral hypoxia during sleep is associated with sleep-disordered breathing (SDB), aging and co-morbidities related to SDB. Eight proton magnetic resonance spectra for sleep and two for periods of arousal were obtained from the right centrum semiovale. All patients were evaluated for the presence or absence of co-morbidities including hypertension, cardiac disease, diabetes mellitus, and hyperlipidemia. Significant lactate signals were found in seven patients with obstructive sleep apnea–hypopnea syndrome (OSAHS) during sleep periods, and none during periods of arousal. Aging was significantly related to the presence or absence of significant lactate signals during sleep periods as determined by logistic regression analysis (
β=0.2480; 95% confidence interval, 0.0905–0.5094;
P=0.0001). Apnea index (AI), apnea–hypopnea index (AHI), and minimum value of peripheral oxyhemoglobin saturation each significantly interacted with age (
P=0.0081, 0.0284, and 0.0302, respectively). Our findings suggest that SDB combined with aging is related to accumulation of lactate during sleep. |
| doi_str_mv | 10.1016/S0197-4580(02)00191-4 |
| format | Article |
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β=0.2480; 95% confidence interval, 0.0905–0.5094;
P=0.0001). Apnea index (AI), apnea–hypopnea index (AHI), and minimum value of peripheral oxyhemoglobin saturation each significantly interacted with age (
P=0.0081, 0.0284, and 0.0302, respectively). Our findings suggest that SDB combined with aging is related to accumulation of lactate during sleep.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/S0197-4580(02)00191-4</identifier><identifier>PMID: 12885583</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Adult ; Aged ; Aging - physiology ; Apnea - metabolism ; Biological and medical sciences ; Body Mass Index ; Brain ; Cerebral Cortex - metabolism ; Cerebral Cortex - pathology ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Female ; Humans ; Hypoxia ; Lactic Acid - metabolism ; Magnetic resonance spectroscopy ; Magnetic Resonance Spectroscopy - instrumentation ; Magnetic Resonance Spectroscopy - methods ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Polysomnography - instrumentation ; Polysomnography - methods ; Regression Analysis ; Sleep apnea syndromes ; Sleep Apnea Syndromes - metabolism ; Sleep Apnea Syndromes - pathology ; Sleep Stages - physiology ; White matter</subject><ispartof>Neurobiology of aging, 2003-09, Vol.24 (5), p.753-760</ispartof><rights>2002 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-5fa2233e98e4b53db55406757238bbaf107278de405407a812d675b01dccadb83</citedby><cites>FETCH-LOGICAL-c422t-5fa2233e98e4b53db55406757238bbaf107278de405407a812d675b01dccadb83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0197-4580(02)00191-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14990187$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12885583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamba, Masayuki</creatorcontrib><creatorcontrib>Inoue, Yuichi</creatorcontrib><creatorcontrib>Higami, Shigeru</creatorcontrib><creatorcontrib>Suto, Yuji</creatorcontrib><title>Age-related changes in cerebral lactate metabolism in sleep-disordered breathing</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Thirty-one patients, aged 22–71 years, with nocturnal apneic episodes and/or habitual snoring were studied with magnetic resonance spectroscopy (MRS) and diagnostic polysomnography separately to determine whether accumulation of lactate caused by cerebral hypoxia during sleep is associated with sleep-disordered breathing (SDB), aging and co-morbidities related to SDB. Eight proton magnetic resonance spectra for sleep and two for periods of arousal were obtained from the right centrum semiovale. All patients were evaluated for the presence or absence of co-morbidities including hypertension, cardiac disease, diabetes mellitus, and hyperlipidemia. Significant lactate signals were found in seven patients with obstructive sleep apnea–hypopnea syndrome (OSAHS) during sleep periods, and none during periods of arousal. Aging was significantly related to the presence or absence of significant lactate signals during sleep periods as determined by logistic regression analysis (
β=0.2480; 95% confidence interval, 0.0905–0.5094;
P=0.0001). Apnea index (AI), apnea–hypopnea index (AHI), and minimum value of peripheral oxyhemoglobin saturation each significantly interacted with age (
P=0.0081, 0.0284, and 0.0302, respectively). Our findings suggest that SDB combined with aging is related to accumulation of lactate during sleep.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging - physiology</subject><subject>Apnea - metabolism</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Brain</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebral Cortex - pathology</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Lactic Acid - metabolism</subject><subject>Magnetic resonance spectroscopy</subject><subject>Magnetic Resonance Spectroscopy - instrumentation</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Polysomnography - instrumentation</subject><subject>Polysomnography - methods</subject><subject>Regression Analysis</subject><subject>Sleep apnea syndromes</subject><subject>Sleep Apnea Syndromes - metabolism</subject><subject>Sleep Apnea Syndromes - pathology</subject><subject>Sleep Stages - physiology</subject><subject>White matter</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0F1LHDEUBuBQlLpqf0LL3CjtxehJJtlkrkSkVmFBwfY65OPMmpKZ2Sazgv_e7Af10quQvM9JwkvIVwoXFOj88gloK2suFHwH9gPKjtb8E5lRIVRNeSsPyOw_OSLHOf8FAMnl_DM5okyp4poZebxeYp0wmgl95Z7NsMRchaFymNAmE6to3FTCqsfJ2DGG3G_iHBFXtQ95TL5IX9mEZnoOw_KUHHYmZvyyX0_In9ufv2_u6sXDr_ub60XtOGNTLTrDWNNgq5Bb0XgrBIe5FJI1ylrTUZBMKo8cyrk0ijJfUgvUO2e8Vc0JOd_du0rjvzXmSfchO4zRDDius5aNYJzBx5BKoeZMsQLFDro05pyw06sUepNeNQW96VxvO9ebQjUwve1c8zL3bf_A2vbo36f2JRdwtgcmOxO7ZAYX8rvjbQtUyeKudg5Lby8Bk84u4ODQh4Ru0n4MH3zlDbpinRk</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>Kamba, Masayuki</creator><creator>Inoue, Yuichi</creator><creator>Higami, Shigeru</creator><creator>Suto, Yuji</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>Age-related changes in cerebral lactate metabolism in sleep-disordered breathing</title><author>Kamba, Masayuki ; Inoue, Yuichi ; Higami, Shigeru ; Suto, Yuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-5fa2233e98e4b53db55406757238bbaf107278de405407a812d675b01dccadb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging - physiology</topic><topic>Apnea - metabolism</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Brain</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cerebral Cortex - pathology</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>Female</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Lactic Acid - metabolism</topic><topic>Magnetic resonance spectroscopy</topic><topic>Magnetic Resonance Spectroscopy - instrumentation</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Polysomnography - instrumentation</topic><topic>Polysomnography - methods</topic><topic>Regression Analysis</topic><topic>Sleep apnea syndromes</topic><topic>Sleep Apnea Syndromes - metabolism</topic><topic>Sleep Apnea Syndromes - pathology</topic><topic>Sleep Stages - physiology</topic><topic>White matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamba, Masayuki</creatorcontrib><creatorcontrib>Inoue, Yuichi</creatorcontrib><creatorcontrib>Higami, Shigeru</creatorcontrib><creatorcontrib>Suto, Yuji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamba, Masayuki</au><au>Inoue, Yuichi</au><au>Higami, Shigeru</au><au>Suto, Yuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related changes in cerebral lactate metabolism in sleep-disordered breathing</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>24</volume><issue>5</issue><spage>753</spage><epage>760</epage><pages>753-760</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Thirty-one patients, aged 22–71 years, with nocturnal apneic episodes and/or habitual snoring were studied with magnetic resonance spectroscopy (MRS) and diagnostic polysomnography separately to determine whether accumulation of lactate caused by cerebral hypoxia during sleep is associated with sleep-disordered breathing (SDB), aging and co-morbidities related to SDB. Eight proton magnetic resonance spectra for sleep and two for periods of arousal were obtained from the right centrum semiovale. All patients were evaluated for the presence or absence of co-morbidities including hypertension, cardiac disease, diabetes mellitus, and hyperlipidemia. Significant lactate signals were found in seven patients with obstructive sleep apnea–hypopnea syndrome (OSAHS) during sleep periods, and none during periods of arousal. Aging was significantly related to the presence or absence of significant lactate signals during sleep periods as determined by logistic regression analysis (
β=0.2480; 95% confidence interval, 0.0905–0.5094;
P=0.0001). Apnea index (AI), apnea–hypopnea index (AHI), and minimum value of peripheral oxyhemoglobin saturation each significantly interacted with age (
P=0.0081, 0.0284, and 0.0302, respectively). Our findings suggest that SDB combined with aging is related to accumulation of lactate during sleep.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>12885583</pmid><doi>10.1016/S0197-4580(02)00191-4</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aging - physiology Apnea - metabolism Biological and medical sciences Body Mass Index Brain Cerebral Cortex - metabolism Cerebral Cortex - pathology Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Female Humans Hypoxia Lactic Acid - metabolism Magnetic resonance spectroscopy Magnetic Resonance Spectroscopy - instrumentation Magnetic Resonance Spectroscopy - methods Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Polysomnography - instrumentation Polysomnography - methods Regression Analysis Sleep apnea syndromes Sleep Apnea Syndromes - metabolism Sleep Apnea Syndromes - pathology Sleep Stages - physiology White matter |
| title | Age-related changes in cerebral lactate metabolism in sleep-disordered breathing |
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