Platelet‐Rich Plasma‐Derived Fibrin Clot Formation Stimulates Collagen Synthesis in Periodontal Ligament and Osteoblastic Cells In Vitro

Background: Platelet‐rich plasma (PRP) contains several growth factors, including platelet‐derived growth factor (PDGF) and transforming growth factor‐β (TGF‐β), at high levels. We have demonstrated the PRP functions like TGF‐β to modulate cell proliferation in a cell‐type specific manner. In additi...

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Veröffentlicht in:	Journal of periodontology (1970) 2003-06, Vol.74 (6), p.858-864
Hauptverfasser:	Kawase, Tomoyuki, Okuda, Kazuhiro, Wolff, Larry F., Yoshie, Hiromasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blood Platelets - physiology Cell Culture Techniques Cell Line Cell Size - drug effects Collagen Collagen - biosynthesis Collagen - drug effects Collagen Type I - biosynthesis Collagen Type I - drug effects Dentistry Extracellular Matrix - drug effects Female fibrin Fibrin - drug effects Fibrinogen - analysis Humans Linear Models Male osteoblasts Osteoblasts - drug effects Osteoblasts - metabolism Periodontal Ligament - drug effects Periodontal Ligament - metabolism periodontal ligament/anatomy and histology plasma, platelet‐rich Platelet-Derived Growth Factor - pharmacology thrombin Thrombin - analysis Thrombin - antagonists & inhibitors Transforming Growth Factor beta - pharmacology Up-Regulation Viscosity
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