Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs

The mutation underlying myotonic dystrophy (DM) has been identified as an expansion of a polymorphic CTG–repeat in a gene encoding protein kinase activity. Brain and heart transcripts of the DM–kinase ( DMR–B15 ) gene are subject to alternative RNA splicing in both human and mouse. The unstable [CTG...

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Veröffentlicht in:	Nature genetics 1992-07, Vol.1 (4), p.261-266
Hauptverfasser:	Baird, S, Segers, B, Mahadevan, M, Korneluk, R. G, Wieringa, B, Amemiya, C, Hofker, M, Jap, P.L, Jansen, G, Iles, D, Wormskamp, N, Lennon, G, Sabourin, L, Carrano, A. V, Hendriks, W, O'Hoy, K, Coerwinkel, M, de Jong, P. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Alternative Splicing Amino Acid Sequence Animal Genetics and Genomics Animals Base Sequence Biomedical and Life Sciences Biomedicine Brain - enzymology Cancer Research DNA - genetics Gene Function Human Genetics Humans Isoenzymes - genetics Male Mice Molecular Sequence Data Myocardium - enzymology Myotonic Dystrophy - enzymology Myotonic Dystrophy - genetics Myotonin-Protein Kinase Oligodeoxyribonucleotides Open Reading Frames Polymorphism, Genetic Protein Kinases - genetics Protein-Serine-Threonine Kinases - genetics Proteins - genetics Repetitive Sequences, Nucleic Acid RNA, Messenger - genetics Testis - enzymology Transcription, Genetic
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