Structure determination of aldose reductase: joys and traps of local symmetry averaging

The structure of aldose reductase, a monomeric enzyme of 314 amino acids which crystallizes in space group P1 with four monomers per asymmetric unit, has been solved using a combination of single isomorphous replacement (SIR), solvent flattening and local symmetry averaging. The self rotation showed...

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Veröffentlicht in:	Acta crystallographica. Section D, Biological crystallography. Biological crystallography., 1993-03, Vol.49 (2), p.246-256
Hauptverfasser:	Tête-Favier, F., Rondeau, J.-M., Podjarny, A., Moras, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biochemistry, Molecular Biology Biological and medical sciences Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Life Sciences Oxidoreductases Physics Structural Biology
Online-Zugang:	Volltext
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