Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans
Recent genetic animal models reveal important roles of platelet P-selectin on progression of atherosclerosis. In the present study, we examine the relation between platelet P-selectin expression and atherosclerotic parameters in 517 subjects. Unrelated subjects (n=517; 235 male and 282 female), incl...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2003-08, Vol.108 (5), p.524-529 |
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| creator | Koyama, Hidenori Maeno, Takaaki Fukumoto, Shinya Shoji, Takuhito Yamane, Takahisa Yokoyama, Hisayo Emoto, Masanori Shoji, Tetsuo Tahara, Hideki Inaba, Masaaki Hino, Masayuki Shioi, Atsushi Miki, Takami Nishizawa, Yoshiki |
| description | Recent genetic animal models reveal important roles of platelet P-selectin on progression of atherosclerosis. In the present study, we examine the relation between platelet P-selectin expression and atherosclerotic parameters in 517 subjects.
Unrelated subjects (n=517; 235 male and 282 female), including 187 with type 2 diabetes, 184 with hypertension, and 366 with hyperlipidemia, were enrolled in the study. P-selectin expression was determined by whole-blood flow cytometry. Arterial stiffness (stiffness index beta) and arterial wall thickness (intima-media thickness [IMT]) were determined by carotid ultrasound. P-selectin expression was significantly and positively correlated with carotid IMT and stiffness index beta. Multiple regression analyses showed that the association of the percentage of P-selectin-positive platelets with carotid IMT was independent of other clinical factors. Moreover, the percentage of P-selectin-positive platelets was higher in subjects with carotid plaque and was an independent factor associated with occurrence of carotid plaque analyzed by multiple logistic regression analysis. Finally, the percentage of P-selectin-positive platelets was positively associated with age, body mass index, systolic and diastolic blood pressure, and HbA1c and inversely associated with HDL cholesterol.
Platelet P-selectin is independently associated with atherosclerotic arterial wall changes in human subjects. |
| doi_str_mv | 10.1161/01.CIR.0000081765.88440.51 |
| format | Article |
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Unrelated subjects (n=517; 235 male and 282 female), including 187 with type 2 diabetes, 184 with hypertension, and 366 with hyperlipidemia, were enrolled in the study. P-selectin expression was determined by whole-blood flow cytometry. Arterial stiffness (stiffness index beta) and arterial wall thickness (intima-media thickness [IMT]) were determined by carotid ultrasound. P-selectin expression was significantly and positively correlated with carotid IMT and stiffness index beta. Multiple regression analyses showed that the association of the percentage of P-selectin-positive platelets with carotid IMT was independent of other clinical factors. Moreover, the percentage of P-selectin-positive platelets was higher in subjects with carotid plaque and was an independent factor associated with occurrence of carotid plaque analyzed by multiple logistic regression analysis. Finally, the percentage of P-selectin-positive platelets was positively associated with age, body mass index, systolic and diastolic blood pressure, and HbA1c and inversely associated with HDL cholesterol.
Platelet P-selectin is independently associated with atherosclerotic arterial wall changes in human subjects.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.0000081765.88440.51</identifier><identifier>PMID: 12860908</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Age Factors ; Blood Platelets - metabolism ; Blood Platelets - pathology ; Blood Pressure ; Body Mass Index ; Carotid Arteries - diagnostic imaging ; Carotid Artery Diseases - diagnosis ; Carotid Artery Diseases - epidemiology ; Carotid Artery Diseases - metabolism ; Cholesterol, HDL - blood ; Female ; Flow Cytometry ; Glycated Hemoglobin A - analysis ; Glycated Hemoglobin A - metabolism ; Humans ; Japan - epidemiology ; Male ; Middle Aged ; Odds Ratio ; P-Selectin - analysis ; P-Selectin - biosynthesis ; Predictive Value of Tests ; Regression Analysis ; Tunica Intima - diagnostic imaging ; Tunica Media - diagnostic imaging ; Ultrasonography</subject><ispartof>Circulation (New York, N.Y.), 2003-08, Vol.108 (5), p.524-529</ispartof><rights>Copyright American Heart Association, Inc. Aug 5 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-deecf000c163f114f7c809d2a95ebb57439dc2eed944cc1257410bc732cbd5e03</citedby><cites>FETCH-LOGICAL-c435t-deecf000c163f114f7c809d2a95ebb57439dc2eed944cc1257410bc732cbd5e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3686,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12860908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koyama, Hidenori</creatorcontrib><creatorcontrib>Maeno, Takaaki</creatorcontrib><creatorcontrib>Fukumoto, Shinya</creatorcontrib><creatorcontrib>Shoji, Takuhito</creatorcontrib><creatorcontrib>Yamane, Takahisa</creatorcontrib><creatorcontrib>Yokoyama, Hisayo</creatorcontrib><creatorcontrib>Emoto, Masanori</creatorcontrib><creatorcontrib>Shoji, Tetsuo</creatorcontrib><creatorcontrib>Tahara, Hideki</creatorcontrib><creatorcontrib>Inaba, Masaaki</creatorcontrib><creatorcontrib>Hino, Masayuki</creatorcontrib><creatorcontrib>Shioi, Atsushi</creatorcontrib><creatorcontrib>Miki, Takami</creatorcontrib><creatorcontrib>Nishizawa, Yoshiki</creatorcontrib><title>Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Recent genetic animal models reveal important roles of platelet P-selectin on progression of atherosclerosis. In the present study, we examine the relation between platelet P-selectin expression and atherosclerotic parameters in 517 subjects.
Unrelated subjects (n=517; 235 male and 282 female), including 187 with type 2 diabetes, 184 with hypertension, and 366 with hyperlipidemia, were enrolled in the study. P-selectin expression was determined by whole-blood flow cytometry. Arterial stiffness (stiffness index beta) and arterial wall thickness (intima-media thickness [IMT]) were determined by carotid ultrasound. P-selectin expression was significantly and positively correlated with carotid IMT and stiffness index beta. Multiple regression analyses showed that the association of the percentage of P-selectin-positive platelets with carotid IMT was independent of other clinical factors. Moreover, the percentage of P-selectin-positive platelets was higher in subjects with carotid plaque and was an independent factor associated with occurrence of carotid plaque analyzed by multiple logistic regression analysis. Finally, the percentage of P-selectin-positive platelets was positively associated with age, body mass index, systolic and diastolic blood pressure, and HbA1c and inversely associated with HDL cholesterol.
Platelet P-selectin is independently associated with atherosclerotic arterial wall changes in human subjects.</description><subject>Age Factors</subject><subject>Blood Platelets - metabolism</subject><subject>Blood Platelets - pathology</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Artery Diseases - diagnosis</subject><subject>Carotid Artery Diseases - epidemiology</subject><subject>Carotid Artery Diseases - metabolism</subject><subject>Cholesterol, HDL - blood</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>P-Selectin - analysis</subject><subject>P-Selectin - biosynthesis</subject><subject>Predictive Value of Tests</subject><subject>Regression Analysis</subject><subject>Tunica Intima - diagnostic imaging</subject><subject>Tunica Media - diagnostic imaging</subject><subject>Ultrasonography</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkduKFDEQhoMo7rj6ChL2wrtuUzn0wTsZPCwsuIheh3R1NZM10z0madZ9e9PuwIK5SJGq_69U8TF2BaIGaOC9gHp__b0W2-mgbUzddVqL2sAztgMjdaWN6p-zXan3VaukvGCvUrorz0a15iW7ANk1ohfdjoXb4DIFyvy2SiVi9jOnP6dIKfll5j5xl9KCvqhGfu_zgbt8oLgkDOXOHvm9C4Hng8dfczHx4ke3VUbuYqb4sGUO69HN6TV7MbmQ6M05XrKfnz_92H-tbr59ud5_vKlQK5OrkQinMixCoyYAPbXYiX6Urjc0DKbVqh9REo291oggSwbEgGVRHEZDQl2yd499T3H5vVLK9ugTUghupmVNtlVGylZ3RXj1n_BuWeNcZrMSZCsbI6CIPjyKsGydIk32FP3RxQcLwm5ArABbgNgnIPYfEGs289vzD-twpPHJeiag_gIH-ojg</recordid><startdate>20030805</startdate><enddate>20030805</enddate><creator>Koyama, Hidenori</creator><creator>Maeno, Takaaki</creator><creator>Fukumoto, Shinya</creator><creator>Shoji, Takuhito</creator><creator>Yamane, Takahisa</creator><creator>Yokoyama, Hisayo</creator><creator>Emoto, Masanori</creator><creator>Shoji, Tetsuo</creator><creator>Tahara, Hideki</creator><creator>Inaba, Masaaki</creator><creator>Hino, Masayuki</creator><creator>Shioi, Atsushi</creator><creator>Miki, Takami</creator><creator>Nishizawa, Yoshiki</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20030805</creationdate><title>Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans</title><author>Koyama, Hidenori ; Maeno, Takaaki ; Fukumoto, Shinya ; Shoji, Takuhito ; Yamane, Takahisa ; Yokoyama, Hisayo ; Emoto, Masanori ; Shoji, Tetsuo ; Tahara, Hideki ; Inaba, Masaaki ; Hino, Masayuki ; Shioi, Atsushi ; Miki, Takami ; Nishizawa, Yoshiki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-deecf000c163f114f7c809d2a95ebb57439dc2eed944cc1257410bc732cbd5e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Age Factors</topic><topic>Blood Platelets - metabolism</topic><topic>Blood Platelets - pathology</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Carotid Artery Diseases - diagnosis</topic><topic>Carotid Artery Diseases - epidemiology</topic><topic>Carotid Artery Diseases - metabolism</topic><topic>Cholesterol, HDL - blood</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>P-Selectin - analysis</topic><topic>P-Selectin - biosynthesis</topic><topic>Predictive Value of Tests</topic><topic>Regression Analysis</topic><topic>Tunica Intima - diagnostic imaging</topic><topic>Tunica Media - diagnostic imaging</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koyama, Hidenori</creatorcontrib><creatorcontrib>Maeno, Takaaki</creatorcontrib><creatorcontrib>Fukumoto, Shinya</creatorcontrib><creatorcontrib>Shoji, Takuhito</creatorcontrib><creatorcontrib>Yamane, Takahisa</creatorcontrib><creatorcontrib>Yokoyama, Hisayo</creatorcontrib><creatorcontrib>Emoto, Masanori</creatorcontrib><creatorcontrib>Shoji, Tetsuo</creatorcontrib><creatorcontrib>Tahara, Hideki</creatorcontrib><creatorcontrib>Inaba, Masaaki</creatorcontrib><creatorcontrib>Hino, Masayuki</creatorcontrib><creatorcontrib>Shioi, Atsushi</creatorcontrib><creatorcontrib>Miki, Takami</creatorcontrib><creatorcontrib>Nishizawa, Yoshiki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koyama, Hidenori</au><au>Maeno, Takaaki</au><au>Fukumoto, Shinya</au><au>Shoji, Takuhito</au><au>Yamane, Takahisa</au><au>Yokoyama, Hisayo</au><au>Emoto, Masanori</au><au>Shoji, Tetsuo</au><au>Tahara, Hideki</au><au>Inaba, Masaaki</au><au>Hino, Masayuki</au><au>Shioi, Atsushi</au><au>Miki, Takami</au><au>Nishizawa, Yoshiki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2003-08-05</date><risdate>2003</risdate><volume>108</volume><issue>5</issue><spage>524</spage><epage>529</epage><pages>524-529</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Recent genetic animal models reveal important roles of platelet P-selectin on progression of atherosclerosis. In the present study, we examine the relation between platelet P-selectin expression and atherosclerotic parameters in 517 subjects.
Unrelated subjects (n=517; 235 male and 282 female), including 187 with type 2 diabetes, 184 with hypertension, and 366 with hyperlipidemia, were enrolled in the study. P-selectin expression was determined by whole-blood flow cytometry. Arterial stiffness (stiffness index beta) and arterial wall thickness (intima-media thickness [IMT]) were determined by carotid ultrasound. P-selectin expression was significantly and positively correlated with carotid IMT and stiffness index beta. Multiple regression analyses showed that the association of the percentage of P-selectin-positive platelets with carotid IMT was independent of other clinical factors. Moreover, the percentage of P-selectin-positive platelets was higher in subjects with carotid plaque and was an independent factor associated with occurrence of carotid plaque analyzed by multiple logistic regression analysis. Finally, the percentage of P-selectin-positive platelets was positively associated with age, body mass index, systolic and diastolic blood pressure, and HbA1c and inversely associated with HDL cholesterol.
Platelet P-selectin is independently associated with atherosclerotic arterial wall changes in human subjects.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>12860908</pmid><doi>10.1161/01.CIR.0000081765.88440.51</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete - AutoHoldings; EZB-FREE-00999 freely available EZB journals |
| subjects | Age Factors Blood Platelets - metabolism Blood Platelets - pathology Blood Pressure Body Mass Index Carotid Arteries - diagnostic imaging Carotid Artery Diseases - diagnosis Carotid Artery Diseases - epidemiology Carotid Artery Diseases - metabolism Cholesterol, HDL - blood Female Flow Cytometry Glycated Hemoglobin A - analysis Glycated Hemoglobin A - metabolism Humans Japan - epidemiology Male Middle Aged Odds Ratio P-Selectin - analysis P-Selectin - biosynthesis Predictive Value of Tests Regression Analysis Tunica Intima - diagnostic imaging Tunica Media - diagnostic imaging Ultrasonography |
| title | Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans |
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