Protein sorting into multivesicular endosomes
Multivesicular endosomes are important as compartments for receptor downregulation and as intermediates in the formation of secretory lysosomes. Work during the past year has shed light on the molecular mechanisms of protein sorting into multivesicular endosomes and yielded information about the mac...
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| Veröffentlicht in: | Current opinion in cell biology 2003-08, Vol.15 (4), p.446-455 |
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| container_title | Current opinion in cell biology |
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| creator | Raiborg, Camilla Rusten, Tor Erik Stenmark, Harald |
| description | Multivesicular endosomes are important as compartments for receptor downregulation and as intermediates in the formation of secretory lysosomes. Work during the past year has shed light on the molecular mechanisms of protein sorting into multivesicular endosomes and yielded information about the machinery involved in multivesicular endosome formation. Monoubiquitination functions as a signal for sorting transmembrane proteins into intraluminal vesicles of multivesicular endosomes and subsequent delivery to lysosomes. A molecular machinery that contains the ubiquitin-binding protein Hrs/Vps27 appears to be central in this sorting process. Three conserved multisubunit complexes, ESCRT-I, -II and -III, are essential for both sorting and multivesicular endosomes formation. Enveloped RNA viruses such as HIV can redirect these complexes from multivesicular endosomes to the plasma membrane to facilitate viral budding. |
| doi_str_mv | 10.1016/S0955-0674(03)00080-2 |
| format | Article |
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Work during the past year has shed light on the molecular mechanisms of protein sorting into multivesicular endosomes and yielded information about the machinery involved in multivesicular endosome formation. Monoubiquitination functions as a signal for sorting transmembrane proteins into intraluminal vesicles of multivesicular endosomes and subsequent delivery to lysosomes. A molecular machinery that contains the ubiquitin-binding protein Hrs/Vps27 appears to be central in this sorting process. Three conserved multisubunit complexes, ESCRT-I, -II and -III, are essential for both sorting and multivesicular endosomes formation. 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Enveloped RNA viruses such as HIV can redirect these complexes from multivesicular endosomes to the plasma membrane to facilitate viral budding.</description><subject>Animals</subject><subject>Carrier Proteins - metabolism</subject><subject>Endocytosis - physiology</subject><subject>Endosomal Sorting Complexes Required for Transport</subject><subject>Endosomes - metabolism</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Macromolecular Substances</subject><subject>Protein Transport - physiology</subject><subject>Proteins - metabolism</subject><subject>Saccharomyces cerevisiae Proteins - metabolism</subject><subject>Transport Vesicles - metabolism</subject><subject>Ubiquitin - metabolism</subject><subject>Vesicular Transport Proteins</subject><subject>Virus Shedding - physiology</subject><issn>0955-0674</issn><issn>1879-0410</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1LxDAQgOEgiruu_gSlJ9FDdZI2TXMSWfyCBQX1HNJkKpG2WZN2wX9v9wM9eprLMzPwEnJK4YoCLa5fQXKeQiHyC8guAaCElO2RKS2FTCGnsE-mv2RCjmL8HFEBTB6SCWWlZKLkU5K-BN-j65LoQ--6j8R1vU_aoendCqMzQ6NDgp310bcYj8lBrZuIJ7s5I-_3d2_zx3Tx_PA0v12kJpOsT2VlZM61MHnOLaIVDISsKwaVQWSs0Fai1cJSyYzVlbR1ZQ3LoaJliVDU2Yycb-8ug_8aMPaqddFg0-gO_RCVyDijGeP_QipLBmVRjJBvoQk-xoC1WgbX6vCtKKh1ULUJqta1FGRqE1Sxce9s92CoWrR_W7uCI7jZAhx7rBwGFY3DzqB1AU2vrHf_vPgBjnyF9A</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Raiborg, Camilla</creator><creator>Rusten, Tor Erik</creator><creator>Stenmark, Harald</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>Protein sorting into multivesicular endosomes</title><author>Raiborg, Camilla ; Rusten, Tor Erik ; Stenmark, Harald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-9bc945a7c445deed72079fb20bcee226ad9eda7d192cdab9dfbdc240b188e06f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Carrier Proteins - metabolism</topic><topic>Endocytosis - physiology</topic><topic>Endosomal Sorting Complexes Required for Transport</topic><topic>Endosomes - metabolism</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Macromolecular Substances</topic><topic>Protein Transport - physiology</topic><topic>Proteins - metabolism</topic><topic>Saccharomyces cerevisiae Proteins - metabolism</topic><topic>Transport Vesicles - metabolism</topic><topic>Ubiquitin - metabolism</topic><topic>Vesicular Transport Proteins</topic><topic>Virus Shedding - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raiborg, Camilla</creatorcontrib><creatorcontrib>Rusten, Tor Erik</creatorcontrib><creatorcontrib>Stenmark, Harald</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raiborg, Camilla</au><au>Rusten, Tor Erik</au><au>Stenmark, Harald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein sorting into multivesicular endosomes</atitle><jtitle>Current opinion in cell biology</jtitle><addtitle>Curr Opin Cell Biol</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>15</volume><issue>4</issue><spage>446</spage><epage>455</epage><pages>446-455</pages><issn>0955-0674</issn><eissn>1879-0410</eissn><abstract>Multivesicular endosomes are important as compartments for receptor downregulation and as intermediates in the formation of secretory lysosomes. 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| ispartof | Current opinion in cell biology, 2003-08, Vol.15 (4), p.446-455 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Carrier Proteins - metabolism Endocytosis - physiology Endosomal Sorting Complexes Required for Transport Endosomes - metabolism Human immunodeficiency virus Humans Macromolecular Substances Protein Transport - physiology Proteins - metabolism Saccharomyces cerevisiae Proteins - metabolism Transport Vesicles - metabolism Ubiquitin - metabolism Vesicular Transport Proteins Virus Shedding - physiology |
| title | Protein sorting into multivesicular endosomes |
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