Cell differentiation and p38(MAPK) cascade are inhibited in human osteoblasts cultured in a three-dimensional clinostat

A three-dimensional (3D) clinostat is a device for multidirectional G force generation. By controlled rotation of two axes, a 3D clinostat cancels the cumulative gravity vector at the center of the device and produces an environment with an average of 10(-3) G over time. We cultured a human osteobla...

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Veröffentlicht in:	In vitro cellular & developmental biology. Animal 2003-01, Vol.39 (1-2), p.89-97
Hauptverfasser:	Yuge, Louis, Hide, Izumi, Kumagai, Takanori, Kumei, Yasuhiro, Takeda, Sin'ichi, Kanno, Masamoto, Sugiyama, Masanori, Kataoka, Katsuko
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcification, Physiologic Cell Culture Techniques - instrumentation Cell Culture Techniques - methods Cell Differentiation - physiology Cell Division - physiology Cell Survival Cells, Cultured Core Binding Factors Enzyme Inhibitors - metabolism Humans Imidazoles - metabolism MAP Kinase Signaling System - physiology Mitogen-Activated Protein Kinases - metabolism Neoplasm Proteins - metabolism Osteoblasts - cytology Osteoblasts - metabolism Osteocalcin - metabolism p38 Mitogen-Activated Protein Kinases Phosphorylation Pyridines - metabolism Transcription Factors - metabolism Weightlessness
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