Design and Synthesis of Paromomycin-Related Heterocycle-Substituted Aminoglycoside Mimetics Based on a Mass Spectrometry RNA-Binding Assay
A good starting point for the design of potent bactericidal compounds is the aminoglycoside paromomycin (1). The A‐ring (shown in red) was replaced with a range of heterocycles. An ESIMS‐based RNA‐binding assay was used to screen the binding affinities of the products.
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| Veröffentlicht in: | Angewandte Chemie International Edition 2003-07, Vol.42 (29), p.3409-3412 |
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| container_end_page | 3412 |
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| container_issue | 29 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Ding, Yili Hofstadler, Steven A. Swayze, Eric E. Risen, Lisa Griffey, Richard H. |
| description | A good starting point for the design of potent bactericidal compounds is the aminoglycoside paromomycin (1). The A‐ring (shown in red) was replaced with a range of heterocycles. An ESIMS‐based RNA‐binding assay was used to screen the binding affinities of the products. |
| doi_str_mv | 10.1002/anie.200351354 |
| format | Article |
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| identifier | ISSN: 1433-7851 |
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| language | eng |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | aminoglycosides Aminoglycosides - chemical synthesis Aminoglycosides - chemistry Aminoglycosides - metabolism antibiotics Binding, Competitive Carbohydrate Sequence Drug Design heterocycles Ligands mass spectrometry Models, Chemical Molecular Sequence Data Molecular Structure Paromomycin - chemistry RNA, Ribosomal, 16S - chemistry RNA, Ribosomal, 16S - metabolism RNA, Ribosomal, 18S - chemistry RNA, Ribosomal, 18S - metabolism Spectrometry, Mass, Electrospray Ionization - methods Structure-Activity Relationship Substrate Specificity synthesis design |
| title | Design and Synthesis of Paromomycin-Related Heterocycle-Substituted Aminoglycoside Mimetics Based on a Mass Spectrometry RNA-Binding Assay |
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