Dynamic, Thermodynamic, and Kinetic Basis for Recognition and Transformation of DNA by Human Immunodeficiency Virus Type 1 Integrase

Specific interactions between retroviral integrase (IN) and long terminal repeats are required for insertion of viral DNA into the host genome. To characterize quantitatively the determinants of substrate specificity, we used a method based on a stepwise increase in ligand complexity. This allowed a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Easton) 2003-08, Vol.42 (30), p.9235-9247
Hauptverfasser:	Bugreev, Dmitrii V, Baranova, Svetlana, Zakharova, Olga D, Parissi, Vincent, Desjobert, Cécile, Sottofattori, Enzo, Balbi, Alessandro, Litvak, Simon, Tarrago-Litvak, Laura, Nevinsky, Georgy A
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA, Single-Stranded - chemistry DNA, Single-Stranded - metabolism DNA, Viral - chemistry DNA, Viral - metabolism Enzyme Activation HIV Integrase - chemistry HIV Integrase - genetics HIV-1 - enzymology HIV-1 - genetics Human immunodeficiency virus 1 Humans Kinetics Models, Chemical Nucleic Acid Heteroduplexes - genetics Nucleic Acid Heteroduplexes - metabolism Oligonucleotides - chemistry Oligonucleotides - metabolism Protein Binding Substrate Specificity Thermodynamics Transformation, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!