Expression of MMP-8 and MMP-13 Genes in the Periodontal Ligament during Tooth Movement in Rats
Periodontal ligament tissue is remodeled on both the tension and compression sides of moving teeth during orthodontic tooth movement. The present study was designed to clarify the hypothesis that the expression of MMP-8 and MMP-13 mRNA is promoted during the remodeling of periodontal ligament tissue...
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| Veröffentlicht in: | Journal of dental research 2003-08, Vol.82 (8), p.646-651 |
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| creator | Takahashi, I. Nishimura, M. Onodera, K. Bae, J.-W. Mitani, H. Okazaki, M. Sasano, Y. |
| description | Periodontal ligament tissue is remodeled on both the tension and compression sides of
moving teeth during orthodontic tooth movement. The present study was designed to
clarify the hypothesis that the expression of MMP-8 and MMP-13 mRNA is promoted
during the remodeling of periodontal ligament tissue in orthodontic tooth movement.
We used the in situ hybridization method and
semi-quantitative reverse-transcription/polymerase chain-reaction analysis to
elucidate the gene expression of MMP-8 and MMP-13 mRNA. Expression of MMP-8 and
MMP-13 mRNA transiently increased on both the compression and tension sides during
active tooth movement in vivo. The gene expression of
MMP-8 and MMP-13 was induced by tension, while compression indirectly promoted the
gene expression of MMP-8 and MMP-13 through soluble factors in
vitro. Thus, we concluded that the expression of MMP-8 and MMP-13 is
differentially regulated by tension and compression, and plays an important role in
the remodeling of the periodontal ligament. |
| doi_str_mv | 10.1177/154405910308200815 |
| format | Article |
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moving teeth during orthodontic tooth movement. The present study was designed to
clarify the hypothesis that the expression of MMP-8 and MMP-13 mRNA is promoted
during the remodeling of periodontal ligament tissue in orthodontic tooth movement.
We used the in situ hybridization method and
semi-quantitative reverse-transcription/polymerase chain-reaction analysis to
elucidate the gene expression of MMP-8 and MMP-13 mRNA. Expression of MMP-8 and
MMP-13 mRNA transiently increased on both the compression and tension sides during
active tooth movement in vivo. The gene expression of
MMP-8 and MMP-13 was induced by tension, while compression indirectly promoted the
gene expression of MMP-8 and MMP-13 through soluble factors in
vitro. Thus, we concluded that the expression of MMP-8 and MMP-13 is
differentially regulated by tension and compression, and plays an important role in
the remodeling of the periodontal ligament.</description><identifier>ISSN: 0022-0345</identifier><identifier>EISSN: 1544-0591</identifier><identifier>DOI: 10.1177/154405910308200815</identifier><identifier>PMID: 12885852</identifier><identifier>CODEN: JDREAF</identifier><language>eng</language><publisher>United States: SAGE Publications</publisher><subject>Animals ; Cells, Cultured ; Collagen Type I - genetics ; Collagen Type III - genetics ; Collagenases - genetics ; Dentistry ; Gene Expression Regulation, Enzymologic - genetics ; In Situ Hybridization ; Male ; Matrix Metalloproteinase 13 ; Matrix Metalloproteinase 8 - genetics ; Models, Animal ; Periodontal Ligament - cytology ; Periodontal Ligament - enzymology ; Pressure ; Rats ; Rats, Sprague-Dawley ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; Stress, Mechanical ; Tooth Movement Techniques</subject><ispartof>Journal of dental research, 2003-08, Vol.82 (8), p.646-651</ispartof><rights>International and American Associations for Dental Research</rights><rights>Copyright American Association for Dental Research/American Academy of Implant Dentistry Aug 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-b440b1d300c526d8edce21e2a46d669de1d288a4f8ee5c00779b90d481b79fed3</citedby><cites>FETCH-LOGICAL-c461t-b440b1d300c526d8edce21e2a46d669de1d288a4f8ee5c00779b90d481b79fed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/154405910308200815$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/154405910308200815$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21824,27929,27930,43626,43627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12885852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takahashi, I.</creatorcontrib><creatorcontrib>Nishimura, M.</creatorcontrib><creatorcontrib>Onodera, K.</creatorcontrib><creatorcontrib>Bae, J.-W.</creatorcontrib><creatorcontrib>Mitani, H.</creatorcontrib><creatorcontrib>Okazaki, M.</creatorcontrib><creatorcontrib>Sasano, Y.</creatorcontrib><title>Expression of MMP-8 and MMP-13 Genes in the Periodontal Ligament during Tooth Movement in Rats</title><title>Journal of dental research</title><addtitle>J Dent Res</addtitle><description>Periodontal ligament tissue is remodeled on both the tension and compression sides of
moving teeth during orthodontic tooth movement. The present study was designed to
clarify the hypothesis that the expression of MMP-8 and MMP-13 mRNA is promoted
during the remodeling of periodontal ligament tissue in orthodontic tooth movement.
We used the in situ hybridization method and
semi-quantitative reverse-transcription/polymerase chain-reaction analysis to
elucidate the gene expression of MMP-8 and MMP-13 mRNA. Expression of MMP-8 and
MMP-13 mRNA transiently increased on both the compression and tension sides during
active tooth movement in vivo. The gene expression of
MMP-8 and MMP-13 was induced by tension, while compression indirectly promoted the
gene expression of MMP-8 and MMP-13 through soluble factors in
vitro. Thus, we concluded that the expression of MMP-8 and MMP-13 is
differentially regulated by tension and compression, and plays an important role in
the remodeling of the periodontal ligament.</description><subject>Animals</subject><subject>Cells, Cultured</subject><subject>Collagen Type I - genetics</subject><subject>Collagen Type III - genetics</subject><subject>Collagenases - genetics</subject><subject>Dentistry</subject><subject>Gene Expression Regulation, Enzymologic - genetics</subject><subject>In Situ Hybridization</subject><subject>Male</subject><subject>Matrix Metalloproteinase 13</subject><subject>Matrix Metalloproteinase 8 - genetics</subject><subject>Models, Animal</subject><subject>Periodontal Ligament - cytology</subject><subject>Periodontal Ligament - enzymology</subject><subject>Pressure</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>Stress, Mechanical</subject><subject>Tooth Movement Techniques</subject><issn>0022-0345</issn><issn>1544-0591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kM1LxDAQxYMoun78Ax4kePBWnUmTNj2K-AW7KKJXS9pM18pusiat6H9v110QFDxNePzem8lj7BDhFDHPz1BJCapASEELAI1qg42WYrJUN9kIQIgEUql22G6MrwBYCJ1usx0UWiutxIg9X34sAsXYesd9wyeT-0Rz4-z3C1N-TY4ibx3vXojfU2i99a4zMz5up2ZOruO2D62b8kfvuxc-8e_0rQ6OB9PFfbbVmFmkg_XcY09Xl48XN8n47vr24nyc1DLDLqmGj1RoU4BaicxqsjUJJGFkZrOssIR2uNjIRhOpGiDPi6oAKzVWedGQTffYySp3EfxbT7Er522saTYzjnwfyzxVmKeoBvD4F_jq--CG20oBhVSZzPIBEiuoDj7GQE25CO3chM8SoVxWX_6tfjAdrZP7ak72x7LuegDOVkA0U_pZ-0_kF5YIiWE</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Takahashi, I.</creator><creator>Nishimura, M.</creator><creator>Onodera, K.</creator><creator>Bae, J.-W.</creator><creator>Mitani, H.</creator><creator>Okazaki, M.</creator><creator>Sasano, Y.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>Expression of MMP-8 and MMP-13 Genes in the Periodontal Ligament during Tooth Movement in Rats</title><author>Takahashi, I. ; 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moving teeth during orthodontic tooth movement. The present study was designed to
clarify the hypothesis that the expression of MMP-8 and MMP-13 mRNA is promoted
during the remodeling of periodontal ligament tissue in orthodontic tooth movement.
We used the in situ hybridization method and
semi-quantitative reverse-transcription/polymerase chain-reaction analysis to
elucidate the gene expression of MMP-8 and MMP-13 mRNA. Expression of MMP-8 and
MMP-13 mRNA transiently increased on both the compression and tension sides during
active tooth movement in vivo. The gene expression of
MMP-8 and MMP-13 was induced by tension, while compression indirectly promoted the
gene expression of MMP-8 and MMP-13 through soluble factors in
vitro. Thus, we concluded that the expression of MMP-8 and MMP-13 is
differentially regulated by tension and compression, and plays an important role in
the remodeling of the periodontal ligament.</abstract><cop>United States</cop><pub>SAGE Publications</pub><pmid>12885852</pmid><doi>10.1177/154405910308200815</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Cells, Cultured Collagen Type I - genetics Collagen Type III - genetics Collagenases - genetics Dentistry Gene Expression Regulation, Enzymologic - genetics In Situ Hybridization Male Matrix Metalloproteinase 13 Matrix Metalloproteinase 8 - genetics Models, Animal Periodontal Ligament - cytology Periodontal Ligament - enzymology Pressure Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Stress, Mechanical Tooth Movement Techniques |
| title | Expression of MMP-8 and MMP-13 Genes in the Periodontal Ligament during Tooth Movement in Rats |
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