Suppressor activity of anergic T cells induced by IL‐10‐treated human dendritic cells: association with IL‐2‐ and CTLA‐4‐dependent G1 arrest of the cell cycle regulated by p27Kip1

We have previously shown that human IL‐10‐treated dendritic cells (DC) induce an antigen‐specific anergy in CD4+ T lymphocytes. These anergic T cells are characterized by an inhibitedproliferation, a reduced production of IL‐2, and additionally display antigen‐specific suppressor activity. In this s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of immunology 2003-07, Vol.33 (7), p.1988-1997
Hauptverfasser:	Kubsch, Sebastian, Graulich, Edith, Knop, Jürgen, Steinbrink, Kerstin
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Anergy Antigens, CD Antigens, Differentiation - metabolism Apoptosis - physiology Cell cycle Cell Cycle Proteins - metabolism Cell Division - physiology Clonal Anergy CTLA-4 Antigen Cyclin-Dependent Kinase Inhibitor p27 Dendritic cell Dendritic Cells - immunology Dendritic Cells - metabolism Humans Immunoconjugates Interleukin-10 - metabolism Interleukin-2 - metabolism p27Kip1 Regulatory T cell T-Lymphocytes - immunology Tumor Suppressor Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!