Impact of Subclinical Hypothyroidism on Serum Total Homocysteine Concentrations, the Prevalence of Coronary Heart Disease (CHD), and CHD Risk Factors in the New Mexico Elder Health Survey
The serum/plasma total homocysteine (tHcy) concentration, now recognized as an independent risk factor for accelerated atherosclerotic disease, is increased in overtly hypothyroid patients, and it decreases with thyroid replacement therapy. Whether or not individuals with subclinical hypothyroidism...
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| Veröffentlicht in: | Thyroid (New York, N.Y.) N.Y.), 2003-06, Vol.13 (6), p.595-600 |
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| creator | Lindeman, Robert D. Romero, Linda J. Schade, David S. Wayne, Sharon Baumgartner, Richard N. Garry, Philip J. |
| description | The serum/plasma total homocysteine (tHcy) concentration, now recognized as an independent risk factor for accelerated atherosclerotic disease, is increased in overtly hypothyroid patients, and it decreases
with thyroid replacement therapy. Whether or not individuals with subclinical hypothyroidism also increase their tHcy concentrations, and whether this elevation might help to explain the increased prevalence
of the atherosclerotic diseases observed in this condition, remains unclear. If individuals with subclinical hypothyroidism have higher tHcy concentrations than euthyroid subjects, there would be added
incentive to treat this condition earlier. In this cross-sectional study (New Mexico Elder Health Survey) of a randomly selected sample of Medicare recipients (age ≥65 years), no significant difference
in serum tHcy concentrations could be detected between the 112 participants with subclinical hypothyroidism (Groups 2 and 3) and the 643 participants with thyrotropin (TSH) values ≤4.6 μU/mL (Group
1) after adjusting for differences in gender, ethnicity, age, and serum concentrations of folate, vitamin B
12
, and creatinine. Only those participants with the highest TSH levels (>10 μU/mL)
(Group 3) had a significantly higher prevalence of coronary heart disease (CHD) when compared against Group 1 participants (
p
= 0.007). No consistent significant differences in the prevalences of
CHD or in the CHD risk factors examined were observed when all participants with subclinical hypothyroidism (Groups 2 and 3 combined) were compared against Group 1 participants. |
| doi_str_mv | 10.1089/105072503322238863 |
| format | Article |
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with thyroid replacement therapy. Whether or not individuals with subclinical hypothyroidism also increase their tHcy concentrations, and whether this elevation might help to explain the increased prevalence
of the atherosclerotic diseases observed in this condition, remains unclear. If individuals with subclinical hypothyroidism have higher tHcy concentrations than euthyroid subjects, there would be added
incentive to treat this condition earlier. In this cross-sectional study (New Mexico Elder Health Survey) of a randomly selected sample of Medicare recipients (age ≥65 years), no significant difference
in serum tHcy concentrations could be detected between the 112 participants with subclinical hypothyroidism (Groups 2 and 3) and the 643 participants with thyrotropin (TSH) values ≤4.6 μU/mL (Group
1) after adjusting for differences in gender, ethnicity, age, and serum concentrations of folate, vitamin B
12
, and creatinine. Only those participants with the highest TSH levels (>10 μU/mL)
(Group 3) had a significantly higher prevalence of coronary heart disease (CHD) when compared against Group 1 participants (
p
= 0.007). No consistent significant differences in the prevalences of
CHD or in the CHD risk factors examined were observed when all participants with subclinical hypothyroidism (Groups 2 and 3 combined) were compared against Group 1 participants.</description><identifier>ISSN: 1050-7256</identifier><identifier>EISSN: 1557-9077</identifier><identifier>DOI: 10.1089/105072503322238863</identifier><identifier>PMID: 12930604</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Aged ; Aged, 80 and over ; Clinical Research Reports ; Coronary Disease - blood ; Coronary Disease - epidemiology ; Creatinine - blood ; Fasting - blood ; Female ; Folic Acid - analogs & derivatives ; Folic Acid - blood ; Health Surveys ; Homocysteine - blood ; Humans ; Hypothyroidism - blood ; Hypothyroidism - complications ; Hypothyroidism - epidemiology ; Male ; New Mexico ; Prevalence ; Risk Factors ; Vitamin B 12 - blood</subject><ispartof>Thyroid (New York, N.Y.), 2003-06, Vol.13 (6), p.595-600</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-48d185cd212937516471e1ccdfa3c29552c9d4ab96bd9f7c1c54761b19aba2d33</citedby><cites>FETCH-LOGICAL-c414t-48d185cd212937516471e1ccdfa3c29552c9d4ab96bd9f7c1c54761b19aba2d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.liebertpub.com/doi/epdf/10.1089/105072503322238863$$EPDF$$P50$$Gmaryannliebert$$H</linktopdf><linktohtml>$$Uhttps://www.liebertpub.com/doi/full/10.1089/105072503322238863$$EHTML$$P50$$Gmaryannliebert$$H</linktohtml><link.rule.ids>314,776,780,3028,21703,27904,27905,55271,55283</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12930604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lindeman, Robert D.</creatorcontrib><creatorcontrib>Romero, Linda J.</creatorcontrib><creatorcontrib>Schade, David S.</creatorcontrib><creatorcontrib>Wayne, Sharon</creatorcontrib><creatorcontrib>Baumgartner, Richard N.</creatorcontrib><creatorcontrib>Garry, Philip J.</creatorcontrib><title>Impact of Subclinical Hypothyroidism on Serum Total Homocysteine Concentrations, the Prevalence of Coronary Heart Disease (CHD), and CHD Risk Factors in the New Mexico Elder Health Survey</title><title>Thyroid (New York, N.Y.)</title><addtitle>Thyroid</addtitle><description>The serum/plasma total homocysteine (tHcy) concentration, now recognized as an independent risk factor for accelerated atherosclerotic disease, is increased in overtly hypothyroid patients, and it decreases
with thyroid replacement therapy. Whether or not individuals with subclinical hypothyroidism also increase their tHcy concentrations, and whether this elevation might help to explain the increased prevalence
of the atherosclerotic diseases observed in this condition, remains unclear. If individuals with subclinical hypothyroidism have higher tHcy concentrations than euthyroid subjects, there would be added
incentive to treat this condition earlier. In this cross-sectional study (New Mexico Elder Health Survey) of a randomly selected sample of Medicare recipients (age ≥65 years), no significant difference
in serum tHcy concentrations could be detected between the 112 participants with subclinical hypothyroidism (Groups 2 and 3) and the 643 participants with thyrotropin (TSH) values ≤4.6 μU/mL (Group
1) after adjusting for differences in gender, ethnicity, age, and serum concentrations of folate, vitamin B
12
, and creatinine. Only those participants with the highest TSH levels (>10 μU/mL)
(Group 3) had a significantly higher prevalence of coronary heart disease (CHD) when compared against Group 1 participants (
p
= 0.007). No consistent significant differences in the prevalences of
CHD or in the CHD risk factors examined were observed when all participants with subclinical hypothyroidism (Groups 2 and 3 combined) were compared against Group 1 participants.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Clinical Research Reports</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - epidemiology</subject><subject>Creatinine - blood</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Folic Acid - analogs & derivatives</subject><subject>Folic Acid - blood</subject><subject>Health Surveys</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Hypothyroidism - blood</subject><subject>Hypothyroidism - complications</subject><subject>Hypothyroidism - epidemiology</subject><subject>Male</subject><subject>New Mexico</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Vitamin B 12 - blood</subject><issn>1050-7256</issn><issn>1557-9077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1TAQhiMEoqXwAiyQVwikBnyJ43iJ0supVC6iZR059kTHkNintlPIs_FydThHYsGGlUeebz7N6C-KlwS_I7iR7wnmWFCOGaOUsqap2aPimHAuSomFeJzrDJSZqI-KZzF-x5jUjWBPiyNCJcM1ro6L31fTTumE_IBu5l6P1lmtRrRZdj5tl-CtsXFC3qEbCPOEbn1au37yeokJrAPUeqfBpaCS9S6eorQF9CXAvRohN1Zx64N3KixoAyokdGYjqAjoTbs5e3uKlDMoV-irjT_QRd7Fh4is--P5BD_RR_hltUfno4GwGsa0zauGe1ieF08GNUZ4cXhPim8X57ftprz-fHnVfrgudUWqVFaNIQ3Xhq5XC07qShAgWptBMU0l51RLU6le1r2Rg9BE80rUpCdS9Yoaxk6K13vvLvi7GWLqJhs1jKNy4OfYCcYJq6TMIN2DOvgYAwzdLtgpX94R3K2Rdf9GlodeHexzP4H5O3LIKAPNHli_lXOjhR5C-h_3A-BGo-M</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Lindeman, Robert D.</creator><creator>Romero, Linda J.</creator><creator>Schade, David S.</creator><creator>Wayne, Sharon</creator><creator>Baumgartner, Richard N.</creator><creator>Garry, Philip J.</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>Impact of Subclinical Hypothyroidism on Serum Total Homocysteine Concentrations, the Prevalence of Coronary Heart Disease (CHD), and CHD Risk Factors in the New Mexico Elder Health Survey</title><author>Lindeman, Robert D. ; 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with thyroid replacement therapy. Whether or not individuals with subclinical hypothyroidism also increase their tHcy concentrations, and whether this elevation might help to explain the increased prevalence
of the atherosclerotic diseases observed in this condition, remains unclear. If individuals with subclinical hypothyroidism have higher tHcy concentrations than euthyroid subjects, there would be added
incentive to treat this condition earlier. In this cross-sectional study (New Mexico Elder Health Survey) of a randomly selected sample of Medicare recipients (age ≥65 years), no significant difference
in serum tHcy concentrations could be detected between the 112 participants with subclinical hypothyroidism (Groups 2 and 3) and the 643 participants with thyrotropin (TSH) values ≤4.6 μU/mL (Group
1) after adjusting for differences in gender, ethnicity, age, and serum concentrations of folate, vitamin B
12
, and creatinine. Only those participants with the highest TSH levels (>10 μU/mL)
(Group 3) had a significantly higher prevalence of coronary heart disease (CHD) when compared against Group 1 participants (
p
= 0.007). No consistent significant differences in the prevalences of
CHD or in the CHD risk factors examined were observed when all participants with subclinical hypothyroidism (Groups 2 and 3 combined) were compared against Group 1 participants.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>12930604</pmid><doi>10.1089/105072503322238863</doi><tpages>6</tpages></addata></record> |
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| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Aged Aged, 80 and over Clinical Research Reports Coronary Disease - blood Coronary Disease - epidemiology Creatinine - blood Fasting - blood Female Folic Acid - analogs & derivatives Folic Acid - blood Health Surveys Homocysteine - blood Humans Hypothyroidism - blood Hypothyroidism - complications Hypothyroidism - epidemiology Male New Mexico Prevalence Risk Factors Vitamin B 12 - blood |
| title | Impact of Subclinical Hypothyroidism on Serum Total Homocysteine Concentrations, the Prevalence of Coronary Heart Disease (CHD), and CHD Risk Factors in the New Mexico Elder Health Survey |
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