Targeted breakage of a human chromosome mediated by cloned human telomeric DNA

Novel approaches to the structural and functional analysis of mammalian chromosomes would be possible if the gross structure of the chromosomes in living cells could be engineered. Controlled modifications can be engineered by conventional targeting techniques based on homologous recombination. Larg...

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Veröffentlicht in:	Nature genetics 1992-12, Vol.2 (4), p.283-287
Hauptverfasser:	Itzhaki, J.E, Barnett, M.A, MacCarthy, A.B, Buckle, V.J, Brown, W.R.A, Porter, A.C.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics biochemical techniques Biomedical and Life Sciences Biomedicine breaks Cancer Research Cell Line chromosome 1 chromosome breakage Chromosome Deletion chromosomes Chromosomes, Human, Pair 1 - ultrastructure cloning Cloning, Molecular cytogenetic analysis cytogenetics DNA DNA - genetics Gene Function gene targeting Genetic Engineering Genetic Techniques homologous recombination Human Genetics Humans man news-and-views Recombination, Genetic targeted chromosome breakage Telomere - ultrastructure telomeres truncation
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