Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42

Efficient chemotaxis requires directional sensing and cell polarization. We describe a signaling mechanism involving G beta gamma, PAK-associated guanine nucleotide exchange factor (PIX alpha), Cdc42, and p21-activated kinase (PAK) 1. This pathway is utilized by chemoattractants to regulate directio...

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Veröffentlicht in:	Cell 2003-07, Vol.114 (2), p.215-227
Hauptverfasser:	Li, Zhong, Hannigan, Michael, Mo, Zhicheng, Liu, Bo, Lu, Wei, Wu, Yue, Smrcka, Alan V, Wu, Guanqing, Li, Lin, Liu, Mingyao, Huang, Chi-Kuang, Wu, Dianqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals cdc42 GTP-Binding Protein - metabolism Cell Polarity - drug effects Cercopithecus aethiops Chemotaxis Complement C5a - pharmacology COS Cells Enzyme Activation Gene Expression Regulation, Enzymologic Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Heterotrimeric GTP-Binding Proteins - metabolism Humans Mice Mice, Knockout Models, Biological Neutrophils - drug effects Neutrophils - metabolism Phosphatidylinositol 3-Kinases - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Signal Transduction Transfection
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