Current concepts and novel applications of LH activity in ovarian stimulation
Luteinizing hormone (LH) is a crucial physiological regulator of the human menstrual cycle. LH activity is also contained in many medications used to treat anovulation and to stimulate multiple folliculogenesis for assisted reproduction techniques. However, LH activity had previously been regarded a...
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| Veröffentlicht in: | Trends in endocrinology and metabolism 2003-08, Vol.14 (6), p.267-273 |
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| container_title | Trends in endocrinology and metabolism |
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| creator | Filicori, Marco Cognigni, Graciela E. Pocognoli, Patrizia Ciampaglia, Walter Bernardi, Silvia |
| description | Luteinizing hormone (LH) is a crucial physiological regulator of the human menstrual cycle. LH activity is also contained in many medications used to treat anovulation and to stimulate multiple folliculogenesis for assisted reproduction techniques. However, LH activity had previously been regarded as just a contaminant of follicle-stimulating hormone (FSH)-containing products and deemed potentially detrimental for reproductive function. Novel experimental and clinical evidence now suggests that the administration of pharmacological amounts of LH activity, instead of being harmful, is therapeutically advantageous, particularly in the support and modulation of ovarian folliculogenesis. The aim of this article is to provide an overview of the effects of LH activity administration in ovarian stimulation and to outline novel unconventional gonadotropin regimens that might improve the efficacy, safety and convenience of ovulation induction. |
| doi_str_mv | 10.1016/S1043-2760(03)00085-7 |
| format | Article |
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LH activity is also contained in many medications used to treat anovulation and to stimulate multiple folliculogenesis for assisted reproduction techniques. However, LH activity had previously been regarded as just a contaminant of follicle-stimulating hormone (FSH)-containing products and deemed potentially detrimental for reproductive function. Novel experimental and clinical evidence now suggests that the administration of pharmacological amounts of LH activity, instead of being harmful, is therapeutically advantageous, particularly in the support and modulation of ovarian folliculogenesis. The aim of this article is to provide an overview of the effects of LH activity administration in ovarian stimulation and to outline novel unconventional gonadotropin regimens that might improve the efficacy, safety and convenience of ovulation induction.</description><subject>Anovulation - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Endocrinology - trends</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone metabolism and regulation</subject><subject>Humans</subject><subject>Luteinizing Hormone - administration & dosage</subject><subject>Luteinizing Hormone - therapeutic use</subject><subject>Mammalian female genital system</subject><subject>Ovarian Follicle - drug effects</subject><subject>Ovulation Induction</subject><subject>Reproductive Techniques, Assisted</subject><subject>Vertebrates: endocrinology</subject><subject>Vertebrates: reproduction</subject><issn>1043-2760</issn><issn>1879-3061</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctKAzEUgOEgitXqIyjZKLoYzXUuK5GiVqi4UNchzZyByDQZk0yhb-_0Il26ShbfScIfhC4ouaOE5vcflAiesSInN4TfEkJKmRUH6ISWRZVxktPDYf9HRug0xm9CqCipPEYjysqKyIqeoLdJHwK4hI13BroUsXY1dn4JLdZd11qjk_UuYt_g2RRrk-zSphW2DvulDlY7HJNd9O2GnaGjRrcRznfrGH09P31Optns_eV18jjLjBA8ZabmFZWsZHUj5pCXDddVzohmFeclY01FoS6qmpt5wQDYPDdUFLkcvGBC5A0fo-vtuV3wPz3EpBY2Gmhb7cD3URVcUia5HKDcQhN8jAEa1QW70GGlKFHrjmrTUa0jKcLVpuMwPkaXuwv6-QLq_dQu3ACudkBHo9smaGds3DtJho9ga_ewdTDkWFoIKhoLQ-raBjBJ1d7-85RfDqiOnQ</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Filicori, Marco</creator><creator>Cognigni, Graciela E.</creator><creator>Pocognoli, Patrizia</creator><creator>Ciampaglia, Walter</creator><creator>Bernardi, Silvia</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>Current concepts and novel applications of LH activity in ovarian stimulation</title><author>Filicori, Marco ; Cognigni, Graciela E. ; Pocognoli, Patrizia ; Ciampaglia, Walter ; Bernardi, Silvia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-cd3915282df4be68f3a9620a2933822f91ed79d3cb72ee2b6c1476582d42446f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Anovulation - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Endocrinology - trends</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone metabolism and regulation</topic><topic>Humans</topic><topic>Luteinizing Hormone - administration & dosage</topic><topic>Luteinizing Hormone - therapeutic use</topic><topic>Mammalian female genital system</topic><topic>Ovarian Follicle - drug effects</topic><topic>Ovulation Induction</topic><topic>Reproductive Techniques, Assisted</topic><topic>Vertebrates: endocrinology</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Filicori, Marco</creatorcontrib><creatorcontrib>Cognigni, Graciela E.</creatorcontrib><creatorcontrib>Pocognoli, Patrizia</creatorcontrib><creatorcontrib>Ciampaglia, Walter</creatorcontrib><creatorcontrib>Bernardi, Silvia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Filicori, Marco</au><au>Cognigni, Graciela E.</au><au>Pocognoli, Patrizia</au><au>Ciampaglia, Walter</au><au>Bernardi, Silvia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current concepts and novel applications of LH activity in ovarian stimulation</atitle><jtitle>Trends in endocrinology and metabolism</jtitle><addtitle>Trends Endocrinol Metab</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>14</volume><issue>6</issue><spage>267</spage><epage>273</epage><pages>267-273</pages><issn>1043-2760</issn><eissn>1879-3061</eissn><abstract>Luteinizing hormone (LH) is a crucial physiological regulator of the human menstrual cycle. 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| ispartof | Trends in endocrinology and metabolism, 2003-08, Vol.14 (6), p.267-273 |
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| subjects | Anovulation - drug therapy Biological and medical sciences Endocrinology - trends Female Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans Luteinizing Hormone - administration & dosage Luteinizing Hormone - therapeutic use Mammalian female genital system Ovarian Follicle - drug effects Ovulation Induction Reproductive Techniques, Assisted Vertebrates: endocrinology Vertebrates: reproduction |
| title | Current concepts and novel applications of LH activity in ovarian stimulation |
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