Evaluation of a test for abnormal rectal mucus for early detection of colon cancer
This report describes the evaluation of a chemical test for T-antigen in rectal mucus as a screening test for colon cancer. The test, called the Mucus Strip Test, detects the disaccharide residue sialic acid-free beta-D-Gal(1-->3)-D-GalNAc or T-antigen, which accumulates in mucus from malignant c...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 1992-05, Vol.1 (4), p.303-306 |
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| creator | Kristal, A R Baker, M S Feld, A D Ylvisaker, J T Morse, K A |
| description | This report describes the evaluation of a chemical test for T-antigen in rectal mucus as a screening test for colon cancer.
The test, called the Mucus Strip Test, detects the disaccharide residue sialic acid-free beta-D-Gal(1-->3)-D-GalNAc or T-antigen,
which accumulates in mucus from malignant cells and colonic mucosa adjacent to cancer but not in normal mucosa. Participants
were an unselected case series of 660 persons undergoing colonoscopy, excluding those with ulcerative colitis, polyposis,
Crohn's disease, or nonspecific inflammatory bowel disease. In the first study (n = 608) rectal mucus was collected after
preparation of the bowel for colonoscopy; in the second study (n = 52) a modified protocol was used to collect mucus approximately
2 weeks before colonoscopy and again following preparation for the procedure. Mucus Strip Test results were compared to the
diagnosis received after colonoscopy, which was classified as cancer, adenomatous polyp(s), and others (normal). Analyses
were also stratified by previous history of large intestinal disease, classified as previous cancer; previous diagnosis of
adenomatous polyp(s); or others. In the first study, T-antigen was detected in approximately 30% of mucus samples, and test
results were independent of both diagnosis at colonoscopy and previous medical history. In the second study, T-antigen was
detected in 85% of samples collected before and 96% of samples collected after preparation for colonoscopy, but test results
were again independent of diagnosis and medical history. |
| format | Article |
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The test, called the Mucus Strip Test, detects the disaccharide residue sialic acid-free beta-D-Gal(1-->3)-D-GalNAc or T-antigen,
which accumulates in mucus from malignant cells and colonic mucosa adjacent to cancer but not in normal mucosa. Participants
were an unselected case series of 660 persons undergoing colonoscopy, excluding those with ulcerative colitis, polyposis,
Crohn's disease, or nonspecific inflammatory bowel disease. In the first study (n = 608) rectal mucus was collected after
preparation of the bowel for colonoscopy; in the second study (n = 52) a modified protocol was used to collect mucus approximately
2 weeks before colonoscopy and again following preparation for the procedure. Mucus Strip Test results were compared to the
diagnosis received after colonoscopy, which was classified as cancer, adenomatous polyp(s), and others (normal). Analyses
were also stratified by previous history of large intestinal disease, classified as previous cancer; previous diagnosis of
adenomatous polyp(s); or others. In the first study, T-antigen was detected in approximately 30% of mucus samples, and test
results were independent of both diagnosis at colonoscopy and previous medical history. In the second study, T-antigen was
detected in 85% of samples collected before and 96% of samples collected after preparation for colonoscopy, but test results
were again independent of diagnosis and medical history.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>PMID: 1303131</identifier><language>eng</language><publisher>United States: American Association for Cancer Research</publisher><subject>Adult ; Aged ; Antigens, Neoplasm - analysis ; Antigens, Tumor-Associated, Carbohydrate - analysis ; Colon - secretion ; Colonic Neoplasms - diagnosis ; Colonic Neoplasms - secretion ; Colonic Polyps - diagnosis ; Colonic Polyps - secretion ; Colonoscopy ; Disaccharides - analysis ; Evaluation Studies as Topic ; Female ; Humans ; Intestinal Mucosa - secretion ; Male ; Middle Aged ; Mucus - chemistry ; Predictive Value of Tests ; Reagent Strips ; Rectum - secretion ; Sensitivity and Specificity</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 1992-05, Vol.1 (4), p.303-306</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1303131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kristal, A R</creatorcontrib><creatorcontrib>Baker, M S</creatorcontrib><creatorcontrib>Feld, A D</creatorcontrib><creatorcontrib>Ylvisaker, J T</creatorcontrib><creatorcontrib>Morse, K A</creatorcontrib><title>Evaluation of a test for abnormal rectal mucus for early detection of colon cancer</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>This report describes the evaluation of a chemical test for T-antigen in rectal mucus as a screening test for colon cancer.
The test, called the Mucus Strip Test, detects the disaccharide residue sialic acid-free beta-D-Gal(1-->3)-D-GalNAc or T-antigen,
which accumulates in mucus from malignant cells and colonic mucosa adjacent to cancer but not in normal mucosa. Participants
were an unselected case series of 660 persons undergoing colonoscopy, excluding those with ulcerative colitis, polyposis,
Crohn's disease, or nonspecific inflammatory bowel disease. In the first study (n = 608) rectal mucus was collected after
preparation of the bowel for colonoscopy; in the second study (n = 52) a modified protocol was used to collect mucus approximately
2 weeks before colonoscopy and again following preparation for the procedure. Mucus Strip Test results were compared to the
diagnosis received after colonoscopy, which was classified as cancer, adenomatous polyp(s), and others (normal). Analyses
were also stratified by previous history of large intestinal disease, classified as previous cancer; previous diagnosis of
adenomatous polyp(s); or others. In the first study, T-antigen was detected in approximately 30% of mucus samples, and test
results were independent of both diagnosis at colonoscopy and previous medical history. In the second study, T-antigen was
detected in 85% of samples collected before and 96% of samples collected after preparation for colonoscopy, but test results
were again independent of diagnosis and medical history.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens, Neoplasm - analysis</subject><subject>Antigens, Tumor-Associated, Carbohydrate - analysis</subject><subject>Colon - secretion</subject><subject>Colonic Neoplasms - diagnosis</subject><subject>Colonic Neoplasms - secretion</subject><subject>Colonic Polyps - diagnosis</subject><subject>Colonic Polyps - secretion</subject><subject>Colonoscopy</subject><subject>Disaccharides - analysis</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Humans</subject><subject>Intestinal Mucosa - secretion</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mucus - chemistry</subject><subject>Predictive Value of Tests</subject><subject>Reagent Strips</subject><subject>Rectum - secretion</subject><subject>Sensitivity and Specificity</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUE1LxDAUDKKs6-pPEHLyVkiapGmPsqwfsCCInsPrS2orbbMmrbL_3uAWPM3AzBvezBlZcyXKTGulzhNnSmVVVahLchXjJ2NMV0qtyIoLJrjga_K6-4Z-hqnzI_UNBTq5ONHGBwr16MMAPQ0OpwTDjHP8UxyE_kitm5Kw3KHvE0EY0YVrctFAH93Nghvy_rB72z5l-5fH5-39PmtzoadM2dIK3UgllSjQoQDOpSgKWVe51qhk6eqcMw7calsyhqg4VmAdotWSg9iQu1PuIfivOb1thi6i63sYnZ-j0UJxXuZVMt4uxrkenDWH0A0QjmYZ4T-o7T7any44cyoSXExVsTXcSJO84hdIdWbE</recordid><startdate>19920501</startdate><enddate>19920501</enddate><creator>Kristal, A R</creator><creator>Baker, M S</creator><creator>Feld, A D</creator><creator>Ylvisaker, J T</creator><creator>Morse, K A</creator><general>American Association for Cancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19920501</creationdate><title>Evaluation of a test for abnormal rectal mucus for early detection of colon cancer</title><author>Kristal, A R ; Baker, M S ; Feld, A D ; Ylvisaker, J T ; Morse, K A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h237t-5d8d37f454536cec3a1143664b9277c548eb2101a1d7d800cc51c9adeccd741a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens, Neoplasm - analysis</topic><topic>Antigens, Tumor-Associated, Carbohydrate - analysis</topic><topic>Colon - secretion</topic><topic>Colonic Neoplasms - diagnosis</topic><topic>Colonic Neoplasms - secretion</topic><topic>Colonic Polyps - diagnosis</topic><topic>Colonic Polyps - secretion</topic><topic>Colonoscopy</topic><topic>Disaccharides - analysis</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Humans</topic><topic>Intestinal Mucosa - secretion</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mucus - chemistry</topic><topic>Predictive Value of Tests</topic><topic>Reagent Strips</topic><topic>Rectum - secretion</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kristal, A R</creatorcontrib><creatorcontrib>Baker, M S</creatorcontrib><creatorcontrib>Feld, A D</creatorcontrib><creatorcontrib>Ylvisaker, J T</creatorcontrib><creatorcontrib>Morse, K A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kristal, A R</au><au>Baker, M S</au><au>Feld, A D</au><au>Ylvisaker, J T</au><au>Morse, K A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of a test for abnormal rectal mucus for early detection of colon cancer</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>1992-05-01</date><risdate>1992</risdate><volume>1</volume><issue>4</issue><spage>303</spage><epage>306</epage><pages>303-306</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>This report describes the evaluation of a chemical test for T-antigen in rectal mucus as a screening test for colon cancer.
The test, called the Mucus Strip Test, detects the disaccharide residue sialic acid-free beta-D-Gal(1-->3)-D-GalNAc or T-antigen,
which accumulates in mucus from malignant cells and colonic mucosa adjacent to cancer but not in normal mucosa. Participants
were an unselected case series of 660 persons undergoing colonoscopy, excluding those with ulcerative colitis, polyposis,
Crohn's disease, or nonspecific inflammatory bowel disease. In the first study (n = 608) rectal mucus was collected after
preparation of the bowel for colonoscopy; in the second study (n = 52) a modified protocol was used to collect mucus approximately
2 weeks before colonoscopy and again following preparation for the procedure. Mucus Strip Test results were compared to the
diagnosis received after colonoscopy, which was classified as cancer, adenomatous polyp(s), and others (normal). Analyses
were also stratified by previous history of large intestinal disease, classified as previous cancer; previous diagnosis of
adenomatous polyp(s); or others. In the first study, T-antigen was detected in approximately 30% of mucus samples, and test
results were independent of both diagnosis at colonoscopy and previous medical history. In the second study, T-antigen was
detected in 85% of samples collected before and 96% of samples collected after preparation for colonoscopy, but test results
were again independent of diagnosis and medical history.</abstract><cop>United States</cop><pub>American Association for Cancer Research</pub><pmid>1303131</pmid><tpages>4</tpages></addata></record> |
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| issn | 1055-9965 1538-7755 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Adult Aged Antigens, Neoplasm - analysis Antigens, Tumor-Associated, Carbohydrate - analysis Colon - secretion Colonic Neoplasms - diagnosis Colonic Neoplasms - secretion Colonic Polyps - diagnosis Colonic Polyps - secretion Colonoscopy Disaccharides - analysis Evaluation Studies as Topic Female Humans Intestinal Mucosa - secretion Male Middle Aged Mucus - chemistry Predictive Value of Tests Reagent Strips Rectum - secretion Sensitivity and Specificity |
| title | Evaluation of a test for abnormal rectal mucus for early detection of colon cancer |
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