Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery

We have previously demonstrated that natto-extracts containing nattokinase (NK) inactivates plasminogen activator inhibitor type 1 and then potentiates fibrinolytic activity. In the present study, we investigated the effects of dietary supplementation with natto-extracts on neointima formation and o...

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Veröffentlicht in:	Life sciences (1973) 2003-07, Vol.73 (10), p.1289-1298
Hauptverfasser:	Suzuki, Yasuhiro, Kondo, Kazunao, Matsumoto, Yuji, Zhao, Bing-Qing, Otsuguro, Kenichi, Maeda, Tetsuya, Tsukamoto, Yoshinori, Urano, Tetsumei, Umemura, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dietary Supplements Disease Models, Animal Femoral Artery - drug effects Femoral Artery - pathology Fibrinolytic Agents - pharmacology Fibrinolytic Agents - therapeutic use Glycine max Intimal thickening Male Mural thrombus Nattokinase Plant Extracts - pharmacology Rats Rats, Sprague-Dawley Soybeans Subtilisins - pharmacology Subtilisins - therapeutic use Thrombolysis Thrombolytic Therapy Thrombosis - diet therapy Thrombosis - etiology Thrombosis - pathology Tunica Intima - drug effects Tunica Intima - pathology Tunica Intima - radiation effects
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