Gangliosides in the human brain development and aging
In this study, brain gangliosides in prenatal and postnatal human life were analyzed. Immunohistochemically, the presence of “c”-pathway of gangliosides (GQ1c) in embryonic brain was only recorded at 5 weeks of gestation. Biochemical results indicated a twofold increase in human cortex ganglioside c...
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| Veröffentlicht in: | Neurochemistry international 1992-04, Vol.20 (3), p.421-431 |
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| creator | Kracun, Ivica Rosner, Harald Drnovsek, Valerija Vukelic, Zeljka Cosovic, Cedomir Trbojevic-Cepe, Milica Kubat, Milovan |
| description | In this study, brain gangliosides in prenatal and postnatal human life were analyzed. Immunohistochemically, the presence of “c”-pathway of gangliosides (GQ1c) in embryonic brain was only recorded at 5 weeks of gestation. Biochemical results indicated a twofold increase in human cortex ganglioside concentration between 16 and 22 weeks of gestation. The increasing ganglioside concentration was based on an increasing GD1a ganglioside fraction in all regions analyzed except cerebellar cortex, which was characterized by increasing GT1b. In this development period, GD3 was found to be localized in the ventricular zone of the cortical wall. After birth, GD1b ganglioside in neuropil of granular cell layer corresponding to growing mossy fibers was expressed in cerebellar cortex. Between birth and 20/30 years of age, a cerebral neocortical difference of ganglioside composition was observed, characterized by lowest GD1a in visual cortex. Analyzing the composition of gangliosides in cortical regions during aging, they were observed to follow region-specific alterations. In frontal cortex, there was a greater decrease in GD1a and GM1 than in GT1b and GD1b, but in occipital (visual) cortex there was no change in individual gangliosides. In hippocampus, GD1a moderately decreased, whereas other fractions were stable. In cerebellar cortex, GD1b and GT1b fractions decreased with aging. |
| doi_str_mv | 10.1016/0197-0186(92)90057-X |
| format | Article |
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Immunohistochemically, the presence of “c”-pathway of gangliosides (GQ1c) in embryonic brain was only recorded at 5 weeks of gestation. Biochemical results indicated a twofold increase in human cortex ganglioside concentration between 16 and 22 weeks of gestation. The increasing ganglioside concentration was based on an increasing GD1a ganglioside fraction in all regions analyzed except cerebellar cortex, which was characterized by increasing GT1b. In this development period, GD3 was found to be localized in the ventricular zone of the cortical wall. After birth, GD1b ganglioside in neuropil of granular cell layer corresponding to growing mossy fibers was expressed in cerebellar cortex. Between birth and 20/30 years of age, a cerebral neocortical difference of ganglioside composition was observed, characterized by lowest GD1a in visual cortex. Analyzing the composition of gangliosides in cortical regions during aging, they were observed to follow region-specific alterations. In frontal cortex, there was a greater decrease in GD1a and GM1 than in GT1b and GD1b, but in occipital (visual) cortex there was no change in individual gangliosides. In hippocampus, GD1a moderately decreased, whereas other fractions were stable. In cerebellar cortex, GD1b and GT1b fractions decreased with aging.</description><identifier>ISSN: 0197-0186</identifier><identifier>EISSN: 1872-9754</identifier><identifier>DOI: 10.1016/0197-0186(92)90057-X</identifier><identifier>PMID: 1304337</identifier><identifier>CODEN: NEUIDS</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Abortion, Legal ; Adult ; Aged ; Aged, 80 and over ; Aging - metabolism ; Biochemistry and metabolism ; Biological and medical sciences ; Brain - embryology ; Brain - growth & development ; Brain - metabolism ; Brain Chemistry ; Central nervous system ; Embryonic and Fetal Development ; Female ; Frontal Lobe - chemistry ; Frontal Lobe - metabolism ; Fundamental and applied biological sciences. Psychology ; Gangliosides - analysis ; Gangliosides - metabolism ; Gestational Age ; Humans ; Infant ; Middle Aged ; Occipital Lobe - chemistry ; Occipital Lobe - metabolism ; Organ Specificity ; Pregnancy ; Vertebrates: nervous system and sense organs</subject><ispartof>Neurochemistry international, 1992-04, Vol.20 (3), p.421-431</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-70cd6902e93b8dba9a27216557c4fec8b613d5cdea741d2e7de96c9e9cac3e083</citedby><cites>FETCH-LOGICAL-c483t-70cd6902e93b8dba9a27216557c4fec8b613d5cdea741d2e7de96c9e9cac3e083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/019701869290057X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5288416$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1304337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kracun, Ivica</creatorcontrib><creatorcontrib>Rosner, Harald</creatorcontrib><creatorcontrib>Drnovsek, Valerija</creatorcontrib><creatorcontrib>Vukelic, Zeljka</creatorcontrib><creatorcontrib>Cosovic, Cedomir</creatorcontrib><creatorcontrib>Trbojevic-Cepe, Milica</creatorcontrib><creatorcontrib>Kubat, Milovan</creatorcontrib><title>Gangliosides in the human brain development and aging</title><title>Neurochemistry international</title><addtitle>Neurochem Int</addtitle><description>In this study, brain gangliosides in prenatal and postnatal human life were analyzed. Immunohistochemically, the presence of “c”-pathway of gangliosides (GQ1c) in embryonic brain was only recorded at 5 weeks of gestation. Biochemical results indicated a twofold increase in human cortex ganglioside concentration between 16 and 22 weeks of gestation. The increasing ganglioside concentration was based on an increasing GD1a ganglioside fraction in all regions analyzed except cerebellar cortex, which was characterized by increasing GT1b. In this development period, GD3 was found to be localized in the ventricular zone of the cortical wall. After birth, GD1b ganglioside in neuropil of granular cell layer corresponding to growing mossy fibers was expressed in cerebellar cortex. Between birth and 20/30 years of age, a cerebral neocortical difference of ganglioside composition was observed, characterized by lowest GD1a in visual cortex. Analyzing the composition of gangliosides in cortical regions during aging, they were observed to follow region-specific alterations. In frontal cortex, there was a greater decrease in GD1a and GM1 than in GT1b and GD1b, but in occipital (visual) cortex there was no change in individual gangliosides. In hippocampus, GD1a moderately decreased, whereas other fractions were stable. In cerebellar cortex, GD1b and GT1b fractions decreased with aging.</description><subject>Abortion, Legal</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - metabolism</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - embryology</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>Brain Chemistry</subject><subject>Central nervous system</subject><subject>Embryonic and Fetal Development</subject><subject>Female</subject><subject>Frontal Lobe - chemistry</subject><subject>Frontal Lobe - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gangliosides - analysis</subject><subject>Gangliosides - metabolism</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant</subject><subject>Middle Aged</subject><subject>Occipital Lobe - chemistry</subject><subject>Occipital Lobe - metabolism</subject><subject>Organ Specificity</subject><subject>Pregnancy</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0197-0186</issn><issn>1872-9754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFq3DAQhkVJ2Ww2fYMGfAghOTgZSZYlXQolJGkh0EsKexOyNLtRseWtZAfy9vF2l82tOQ3DfP_M8BHylcI1BVrfANWyBKrqS82uNICQ5fITmVMlWamlqI7I_IAck5Oc_wCA1CBmZEY5VJzLOREPNq7b0OfgMRchFsMzFs9jZ2PRJDv1Hl-w7TcdxqGw0Rd2HeL6lHxe2Tbjl31dkN_3d0-3P8rHXw8_b78_lq5SfCglOF9rYKh5o3xjtWWS0VoI6aoVOtXUlHvhPFpZUc9QetS106iddRxB8QW52O3dpP7viHkwXcgO29ZG7MdsJBegJbAPQVpPd5XWE1jtQJf6nBOuzCaFzqZXQ8FstZqtM7N1ZjQz_7Sa5RQ72-8fmw79e2jncZqf7-c2O9uuko0u5AMmmFIVrSfs2w7DSdpLwGSyCxgd-pDQDcb34f9_vAHPBZLv</recordid><startdate>19920401</startdate><enddate>19920401</enddate><creator>Kracun, Ivica</creator><creator>Rosner, Harald</creator><creator>Drnovsek, Valerija</creator><creator>Vukelic, Zeljka</creator><creator>Cosovic, Cedomir</creator><creator>Trbojevic-Cepe, Milica</creator><creator>Kubat, Milovan</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19920401</creationdate><title>Gangliosides in the human brain development and aging</title><author>Kracun, Ivica ; Rosner, Harald ; Drnovsek, Valerija ; Vukelic, Zeljka ; Cosovic, Cedomir ; Trbojevic-Cepe, Milica ; Kubat, Milovan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-70cd6902e93b8dba9a27216557c4fec8b613d5cdea741d2e7de96c9e9cac3e083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Abortion, Legal</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - metabolism</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain - embryology</topic><topic>Brain - growth & development</topic><topic>Brain - metabolism</topic><topic>Brain Chemistry</topic><topic>Central nervous system</topic><topic>Embryonic and Fetal Development</topic><topic>Female</topic><topic>Frontal Lobe - chemistry</topic><topic>Frontal Lobe - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gangliosides - analysis</topic><topic>Gangliosides - metabolism</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant</topic><topic>Middle Aged</topic><topic>Occipital Lobe - chemistry</topic><topic>Occipital Lobe - metabolism</topic><topic>Organ Specificity</topic><topic>Pregnancy</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kracun, Ivica</creatorcontrib><creatorcontrib>Rosner, Harald</creatorcontrib><creatorcontrib>Drnovsek, Valerija</creatorcontrib><creatorcontrib>Vukelic, Zeljka</creatorcontrib><creatorcontrib>Cosovic, Cedomir</creatorcontrib><creatorcontrib>Trbojevic-Cepe, Milica</creatorcontrib><creatorcontrib>Kubat, Milovan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemistry international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kracun, Ivica</au><au>Rosner, Harald</au><au>Drnovsek, Valerija</au><au>Vukelic, Zeljka</au><au>Cosovic, Cedomir</au><au>Trbojevic-Cepe, Milica</au><au>Kubat, Milovan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gangliosides in the human brain development and aging</atitle><jtitle>Neurochemistry international</jtitle><addtitle>Neurochem Int</addtitle><date>1992-04-01</date><risdate>1992</risdate><volume>20</volume><issue>3</issue><spage>421</spage><epage>431</epage><pages>421-431</pages><issn>0197-0186</issn><eissn>1872-9754</eissn><coden>NEUIDS</coden><abstract>In this study, brain gangliosides in prenatal and postnatal human life were analyzed. Immunohistochemically, the presence of “c”-pathway of gangliosides (GQ1c) in embryonic brain was only recorded at 5 weeks of gestation. Biochemical results indicated a twofold increase in human cortex ganglioside concentration between 16 and 22 weeks of gestation. The increasing ganglioside concentration was based on an increasing GD1a ganglioside fraction in all regions analyzed except cerebellar cortex, which was characterized by increasing GT1b. In this development period, GD3 was found to be localized in the ventricular zone of the cortical wall. After birth, GD1b ganglioside in neuropil of granular cell layer corresponding to growing mossy fibers was expressed in cerebellar cortex. Between birth and 20/30 years of age, a cerebral neocortical difference of ganglioside composition was observed, characterized by lowest GD1a in visual cortex. Analyzing the composition of gangliosides in cortical regions during aging, they were observed to follow region-specific alterations. 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| ispartof | Neurochemistry international, 1992-04, Vol.20 (3), p.421-431 |
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| subjects | Abortion, Legal Adult Aged Aged, 80 and over Aging - metabolism Biochemistry and metabolism Biological and medical sciences Brain - embryology Brain - growth & development Brain - metabolism Brain Chemistry Central nervous system Embryonic and Fetal Development Female Frontal Lobe - chemistry Frontal Lobe - metabolism Fundamental and applied biological sciences. Psychology Gangliosides - analysis Gangliosides - metabolism Gestational Age Humans Infant Middle Aged Occipital Lobe - chemistry Occipital Lobe - metabolism Organ Specificity Pregnancy Vertebrates: nervous system and sense organs |
| title | Gangliosides in the human brain development and aging |
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