Allele losses in the region 17q12–21 in familial breast and ovarian cancer involve the wild–type chromosome
A predisposing gene for breast and ovarian cancer has recently been mapped to chromosome 17q12–21. If this gene is a tumour suppressor gene, allele losses would be expected in the tumours of affected family members and the losses should affect the wild–type chromosome, reflecting the need for inacti...
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| Veröffentlicht in: | Nature genetics 1992-10, Vol.2 (2), p.128-131 |
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| container_title | Nature genetics |
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| creator | Smith, S.A. Easton, D.F. Evans, D.G.R. Ponder, B.A.J. |
| description | A predisposing gene for breast and ovarian cancer has recently been mapped to chromosome 17q12–21. If this gene is a tumour suppressor gene, allele losses would be expected in the tumours of affected family members and the losses should affect the wild–type chromosome, reflecting the need for inactivation of the wild–type allele at the predisposing locus. In four multiple case breast–ovarian cancer families, we have found that in each of nine tumours which showed allele losses, the losses were from the wild–type chromosome. This suggests that the putative ‘breast–ovarian’ cancer gene is indeed a tumour suppressor gene. |
| doi_str_mv | 10.1038/ng1092-128 |
| format | Article |
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| ispartof | Nature genetics, 1992-10, Vol.2 (2), p.128-131 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Agriculture Alleles Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Breast Neoplasms - genetics Cancer Research Chromosome Mapping Chromosomes, Human, Pair 17 Female Gene Deletion Gene Function Genes, Tumor Suppressor Human Genetics Humans Male Ovarian Neoplasms - genetics Pedigree |
| title | Allele losses in the region 17q12–21 in familial breast and ovarian cancer involve the wild–type chromosome |
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