Tubal damage in infertile women: prediction using chlamydia serology
BACKGROUND: The study explores the relationship between serum chlamydia antibody titres (CATs) and detection of tubal damage in infertile women. METHODS: The tubal status and pelvic findings in 1006 women undergoing laparoscopy for infertility were related to CAT, which was measured using the whole‐...
Gespeichert in:
| Veröffentlicht in: | Human reproduction (Oxford) 2003-09, Vol.18 (9), p.1841-1847 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1847 |
|---|---|
| container_issue | 9 |
| container_start_page | 1841 |
| container_title | Human reproduction (Oxford) |
| container_volume | 18 |
| creator | Akande, Valentine A. Hunt, Linda P. Cahill, David J. Caul, E.Owen Ford, W.Christopher L. Jenkins, Julian M. |
| description | BACKGROUND: The study explores the relationship between serum chlamydia antibody titres (CATs) and detection of tubal damage in infertile women. METHODS: The tubal status and pelvic findings in 1006 women undergoing laparoscopy for infertility were related to CAT, which was measured using the whole‐cell inclusion immunofluorescence test. RESULTS: A negative correlation between CAT and age was noted. A linear trend between serum CAT and the likelihood of tubal damage, including severe damage, was observed (P |
| doi_str_mv | 10.1093/humrep/deg347 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73504692</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/humrep/deg347</oup_id><sourcerecordid>73504692</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-93aab786f63129907dd5e4675d651701b9f9266477e0221b5f94bd0e41c4af453</originalsourceid><addsrcrecordid>eNqFkE1r3DAQhkVoSDabHnstpoeSi7OS9bXuLbhJNiXQyyaUvQjZGm-0tS1Hsmn230fBSwu9BAZmDg_vzDwIfSL4kuCcLp7G1kO_MLClTB6hGWECpxnl-AOa4UwsU0IEOUVnIewwjuNSnKBTkuUZJVTM0Pf1WOomMbrVW0hsF6sGP9gGkj-uhe5b0nswthqs65Ix2G6bVE-NbvfG6iSAd43b7s_Rca2bAB8PfY4ebq7XxSq9_3l7V1zdpxXjfEhzqnUpl6IWNB6QY2kMByYkN4ITiUmZ13kmBJMScJaRktc5Kw0GRiqma8bpHH2dcnvvnkcIg2ptqKBpdAduDErGt5mIr83Rl__AnRt9F29TGYkKpGQ4QukEVd6F4KFWvbet9ntFsHpzqya3anIb-c-H0LFswfyjDzIjcDEBbuzfzTrstmGAl7-w9r-VkFRytfq1UZvix0Y-rh9VQV8B95uSwA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211867740</pqid></control><display><type>article</type><title>Tubal damage in infertile women: prediction using chlamydia serology</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Akande, Valentine A. ; Hunt, Linda P. ; Cahill, David J. ; Caul, E.Owen ; Ford, W.Christopher L. ; Jenkins, Julian M.</creator><creatorcontrib>Akande, Valentine A. ; Hunt, Linda P. ; Cahill, David J. ; Caul, E.Owen ; Ford, W.Christopher L. ; Jenkins, Julian M.</creatorcontrib><description><![CDATA[BACKGROUND: The study explores the relationship between serum chlamydia antibody titres (CATs) and detection of tubal damage in infertile women. METHODS: The tubal status and pelvic findings in 1006 women undergoing laparoscopy for infertility were related to CAT, which was measured using the whole‐cell inclusion immunofluorescence test. RESULTS: A negative correlation between CAT and age was noted. A linear trend between serum CAT and the likelihood of tubal damage, including severe damage, was observed (P < 0.001). Titres in women with tubal damage (median 1:1024; range <1:64–1:4096) were significantly (P < 0.001) higher than in women with endometriosis alone (median <1:64; range <1:64–1:512) or those with a normal pelvis (median <1:64; range <1:64–1:1024). Women with positive titres were more likely to have pelvic adhesions than tubal occlusion unless titres were very high, when tubal damage was likely to be more severe. CONCLUSIONS: CATs are of predictive value in the detection of tubal damage and are quantitatively related to the severity of damage. For practical clinical purposes, Chlamydia serology is useful mainly as a screening test for the likelihood of tubal damage in infertile women and may facilitate decisions on which women should proceed with further investigations without delay.]]></description><identifier>ISSN: 0268-1161</identifier><identifier>ISSN: 1460-2350</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/deg347</identifier><identifier>PMID: 12923136</identifier><identifier>CODEN: HRUPF8</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Aging ; Antibodies, Fungal - blood ; Chlamydia Infections - complications ; Chlamydia Infections - diagnosis ; Chlamydia Infections - immunology ; Fallopian Tube Diseases - complications ; Fallopian Tube Diseases - diagnosis ; Fallopian Tube Diseases - microbiology ; Fallopian Tube Diseases - physiopathology ; Female ; Fluorescent Antibody Technique - methods ; Humans ; Infertility, Female - etiology ; Key words: chlamydia/infertility/pelvis/serology/tubal damage ; Laparoscopy ; Likelihood Functions ; Middle Aged ; Prognosis ; Serologic Tests ; Severity of Illness Index</subject><ispartof>Human reproduction (Oxford), 2003-09, Vol.18 (9), p.1841-1847</ispartof><rights>2003</rights><rights>Copyright Oxford University Press(England) Sep 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-93aab786f63129907dd5e4675d651701b9f9266477e0221b5f94bd0e41c4af453</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12923136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akande, Valentine A.</creatorcontrib><creatorcontrib>Hunt, Linda P.</creatorcontrib><creatorcontrib>Cahill, David J.</creatorcontrib><creatorcontrib>Caul, E.Owen</creatorcontrib><creatorcontrib>Ford, W.Christopher L.</creatorcontrib><creatorcontrib>Jenkins, Julian M.</creatorcontrib><title>Tubal damage in infertile women: prediction using chlamydia serology</title><title>Human reproduction (Oxford)</title><addtitle>Hum. Reprod</addtitle><addtitle>Hum. Reprod</addtitle><description><![CDATA[BACKGROUND: The study explores the relationship between serum chlamydia antibody titres (CATs) and detection of tubal damage in infertile women. METHODS: The tubal status and pelvic findings in 1006 women undergoing laparoscopy for infertility were related to CAT, which was measured using the whole‐cell inclusion immunofluorescence test. RESULTS: A negative correlation between CAT and age was noted. A linear trend between serum CAT and the likelihood of tubal damage, including severe damage, was observed (P < 0.001). Titres in women with tubal damage (median 1:1024; range <1:64–1:4096) were significantly (P < 0.001) higher than in women with endometriosis alone (median <1:64; range <1:64–1:512) or those with a normal pelvis (median <1:64; range <1:64–1:1024). Women with positive titres were more likely to have pelvic adhesions than tubal occlusion unless titres were very high, when tubal damage was likely to be more severe. CONCLUSIONS: CATs are of predictive value in the detection of tubal damage and are quantitatively related to the severity of damage. For practical clinical purposes, Chlamydia serology is useful mainly as a screening test for the likelihood of tubal damage in infertile women and may facilitate decisions on which women should proceed with further investigations without delay.]]></description><subject>Adult</subject><subject>Aging</subject><subject>Antibodies, Fungal - blood</subject><subject>Chlamydia Infections - complications</subject><subject>Chlamydia Infections - diagnosis</subject><subject>Chlamydia Infections - immunology</subject><subject>Fallopian Tube Diseases - complications</subject><subject>Fallopian Tube Diseases - diagnosis</subject><subject>Fallopian Tube Diseases - microbiology</subject><subject>Fallopian Tube Diseases - physiopathology</subject><subject>Female</subject><subject>Fluorescent Antibody Technique - methods</subject><subject>Humans</subject><subject>Infertility, Female - etiology</subject><subject>Key words: chlamydia/infertility/pelvis/serology/tubal damage</subject><subject>Laparoscopy</subject><subject>Likelihood Functions</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Serologic Tests</subject><subject>Severity of Illness Index</subject><issn>0268-1161</issn><issn>1460-2350</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVoSDabHnstpoeSi7OS9bXuLbhJNiXQyyaUvQjZGm-0tS1Hsmn230fBSwu9BAZmDg_vzDwIfSL4kuCcLp7G1kO_MLClTB6hGWECpxnl-AOa4UwsU0IEOUVnIewwjuNSnKBTkuUZJVTM0Pf1WOomMbrVW0hsF6sGP9gGkj-uhe5b0nswthqs65Ix2G6bVE-NbvfG6iSAd43b7s_Rca2bAB8PfY4ebq7XxSq9_3l7V1zdpxXjfEhzqnUpl6IWNB6QY2kMByYkN4ITiUmZ13kmBJMScJaRktc5Kw0GRiqma8bpHH2dcnvvnkcIg2ptqKBpdAduDErGt5mIr83Rl__AnRt9F29TGYkKpGQ4QukEVd6F4KFWvbet9ntFsHpzqya3anIb-c-H0LFswfyjDzIjcDEBbuzfzTrstmGAl7-w9r-VkFRytfq1UZvix0Y-rh9VQV8B95uSwA</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>Akande, Valentine A.</creator><creator>Hunt, Linda P.</creator><creator>Cahill, David J.</creator><creator>Caul, E.Owen</creator><creator>Ford, W.Christopher L.</creator><creator>Jenkins, Julian M.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>Tubal damage in infertile women: prediction using chlamydia serology</title><author>Akande, Valentine A. ; Hunt, Linda P. ; Cahill, David J. ; Caul, E.Owen ; Ford, W.Christopher L. ; Jenkins, Julian M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-93aab786f63129907dd5e4675d651701b9f9266477e0221b5f94bd0e41c4af453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aging</topic><topic>Antibodies, Fungal - blood</topic><topic>Chlamydia Infections - complications</topic><topic>Chlamydia Infections - diagnosis</topic><topic>Chlamydia Infections - immunology</topic><topic>Fallopian Tube Diseases - complications</topic><topic>Fallopian Tube Diseases - diagnosis</topic><topic>Fallopian Tube Diseases - microbiology</topic><topic>Fallopian Tube Diseases - physiopathology</topic><topic>Female</topic><topic>Fluorescent Antibody Technique - methods</topic><topic>Humans</topic><topic>Infertility, Female - etiology</topic><topic>Key words: chlamydia/infertility/pelvis/serology/tubal damage</topic><topic>Laparoscopy</topic><topic>Likelihood Functions</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Serologic Tests</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akande, Valentine A.</creatorcontrib><creatorcontrib>Hunt, Linda P.</creatorcontrib><creatorcontrib>Cahill, David J.</creatorcontrib><creatorcontrib>Caul, E.Owen</creatorcontrib><creatorcontrib>Ford, W.Christopher L.</creatorcontrib><creatorcontrib>Jenkins, Julian M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akande, Valentine A.</au><au>Hunt, Linda P.</au><au>Cahill, David J.</au><au>Caul, E.Owen</au><au>Ford, W.Christopher L.</au><au>Jenkins, Julian M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tubal damage in infertile women: prediction using chlamydia serology</atitle><jtitle>Human reproduction (Oxford)</jtitle><stitle>Hum. Reprod</stitle><addtitle>Hum. Reprod</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>18</volume><issue>9</issue><spage>1841</spage><epage>1847</epage><pages>1841-1847</pages><issn>0268-1161</issn><issn>1460-2350</issn><eissn>1460-2350</eissn><coden>HRUPF8</coden><abstract><![CDATA[BACKGROUND: The study explores the relationship between serum chlamydia antibody titres (CATs) and detection of tubal damage in infertile women. METHODS: The tubal status and pelvic findings in 1006 women undergoing laparoscopy for infertility were related to CAT, which was measured using the whole‐cell inclusion immunofluorescence test. RESULTS: A negative correlation between CAT and age was noted. A linear trend between serum CAT and the likelihood of tubal damage, including severe damage, was observed (P < 0.001). Titres in women with tubal damage (median 1:1024; range <1:64–1:4096) were significantly (P < 0.001) higher than in women with endometriosis alone (median <1:64; range <1:64–1:512) or those with a normal pelvis (median <1:64; range <1:64–1:1024). Women with positive titres were more likely to have pelvic adhesions than tubal occlusion unless titres were very high, when tubal damage was likely to be more severe. CONCLUSIONS: CATs are of predictive value in the detection of tubal damage and are quantitatively related to the severity of damage. For practical clinical purposes, Chlamydia serology is useful mainly as a screening test for the likelihood of tubal damage in infertile women and may facilitate decisions on which women should proceed with further investigations without delay.]]></abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>12923136</pmid><doi>10.1093/humrep/deg347</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-1161 |
| ispartof | Human reproduction (Oxford), 2003-09, Vol.18 (9), p.1841-1847 |
| issn | 0268-1161 1460-2350 1460-2350 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73504692 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Aging Antibodies, Fungal - blood Chlamydia Infections - complications Chlamydia Infections - diagnosis Chlamydia Infections - immunology Fallopian Tube Diseases - complications Fallopian Tube Diseases - diagnosis Fallopian Tube Diseases - microbiology Fallopian Tube Diseases - physiopathology Female Fluorescent Antibody Technique - methods Humans Infertility, Female - etiology Key words: chlamydia/infertility/pelvis/serology/tubal damage Laparoscopy Likelihood Functions Middle Aged Prognosis Serologic Tests Severity of Illness Index |
| title | Tubal damage in infertile women: prediction using chlamydia serology |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T19%3A30%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tubal%20damage%20in%20infertile%20women:%20prediction%20using%20chlamydia%20serology&rft.jtitle=Human%20reproduction%20(Oxford)&rft.au=Akande,%20Valentine%20A.&rft.date=2003-09-01&rft.volume=18&rft.issue=9&rft.spage=1841&rft.epage=1847&rft.pages=1841-1847&rft.issn=0268-1161&rft.eissn=1460-2350&rft.coden=HRUPF8&rft_id=info:doi/10.1093/humrep/deg347&rft_dat=%3Cproquest_cross%3E73504692%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=211867740&rft_id=info:pmid/12923136&rft_oup_id=10.1093/humrep/deg347&rfr_iscdi=true |