Lactic dehydrogenase isoenzymes in the cerebrospinal fluid of patients with systemic cancer
Lactic dehydrogenase (LDH) isoenzymes were measured in the cerebrospinal fluid (CSF) in a group of patients suffering a variety of cancer‐related neurologic problems. LDH‐5 isoenzyme as a percentage of total LDH activity was abnormally elevated (above 10 to 15%) in leptomeningeal infiltration by car...
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| Veröffentlicht in: | Cancer 1981-06, Vol.47 (11), p.2654-2659 |
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| container_title | Cancer |
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| creator | Fleisher, Martin Wasserstrom, William R. Schold, S. Clifford Schwartz, Morton K. Posner, Jerome B. |
| description | Lactic dehydrogenase (LDH) isoenzymes were measured in the cerebrospinal fluid (CSF) in a group of patients suffering a variety of cancer‐related neurologic problems. LDH‐5 isoenzyme as a percentage of total LDH activity was abnormally elevated (above 10 to 15%) in leptomeningeal infiltration by carcinoma (breast carcinoma, lung carcinoma, and malignant melanoma) but not in other types of CNS metastases. Abnormal LDH isoenzyme patterns were also seen with CSF infections in which a granulocytic pleocytosis was present. In the absence of infection, an elevated LDH isoenzyme 5:1 ratio suggested leptomeningeal tumor and, when used with other CSF markers (beta‐glucuronidase and CEA), LDH isoenzymes aid in early detection of this metastatic neoplastic process. They may also help to differentiate leptomeningeal tumor from other chronic meningitides. Measurement of CSF markers also aids in assessing the effectiveness of treatment since marker levels often vary with the clinical course. |
| doi_str_mv | 10.1002/1097-0142(19810601)47:11<2654::AID-CNCR2820471122>3.0.CO;2-Z |
| format | Article |
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They may also help to differentiate leptomeningeal tumor from other chronic meningitides. 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Clifford</creatorcontrib><creatorcontrib>Schwartz, Morton K.</creatorcontrib><creatorcontrib>Posner, Jerome B.</creatorcontrib><title>Lactic dehydrogenase isoenzymes in the cerebrospinal fluid of patients with systemic cancer</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Lactic dehydrogenase (LDH) isoenzymes were measured in the cerebrospinal fluid (CSF) in a group of patients suffering a variety of cancer‐related neurologic problems. LDH‐5 isoenzyme as a percentage of total LDH activity was abnormally elevated (above 10 to 15%) in leptomeningeal infiltration by carcinoma (breast carcinoma, lung carcinoma, and malignant melanoma) but not in other types of CNS metastases. Abnormal LDH isoenzyme patterns were also seen with CSF infections in which a granulocytic pleocytosis was present. In the absence of infection, an elevated LDH isoenzyme 5:1 ratio suggested leptomeningeal tumor and, when used with other CSF markers (beta‐glucuronidase and CEA), LDH isoenzymes aid in early detection of this metastatic neoplastic process. They may also help to differentiate leptomeningeal tumor from other chronic meningitides. Measurement of CSF markers also aids in assessing the effectiveness of treatment since marker levels often vary with the clinical course.</description><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - secondary</subject><subject>Breast Neoplasms</subject><subject>Carcinoembryonic Antigen - cerebrospinal fluid</subject><subject>Female</subject><subject>Glucuronidase - cerebrospinal fluid</subject><subject>Humans</subject><subject>Isoenzymes</subject><subject>L-Lactate Dehydrogenase - cerebrospinal fluid</subject><subject>Lung Neoplasms</subject><subject>Male</subject><subject>Melanoma</subject><subject>Meningeal Neoplasms - diagnosis</subject><subject>Meningeal Neoplasms - secondary</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkN9r1EAQxxdR6ln9E4R9En3IOfsju8lZhJL6o3B4IH2QKgybZNJbySVnNkdJ__rucWdBHwSfhpnvzHdmPoxdCJgLAPlWQG4TEFq-FnkmwIB4o-1CiDNpUr1YnF9eJMWX4qvMJGgrhJTv1RzmxeqdTK4fsdnD-GM2A4AsSbX69pQ9C-FnTK1M1Qk7sdJAltoZ-7501egrXtN6qof-hjoXiPvQU3c3bShw3_FxTbyigcqhD1vfuZY37c7XvG_41o2eujHwWz-ueZjCSJvoVrkuDjxnTxrXBnpxjKfs6uOHq-Jzslx9uizOl0mlrZRJpk2j83ibalxdljnYhmplqTHQZKWRuSqhNiJWK2Nt1Ctbu9xkmbMgjVCn7NXBdjv0v3YURtz4UFHbuo76XUCrUtCpSmPjj0NjFR8JAzW4HfzGDRMKwD163LPDPTv8jR61RSFwjx4xosc_0aNCwGKFEq-j_cvjHbtyQ_WD-ZF11G8O-q1vafrP3f9c_Zei7gETA6KF</recordid><startdate>19810601</startdate><enddate>19810601</enddate><creator>Fleisher, Martin</creator><creator>Wasserstrom, William R.</creator><creator>Schold, S. 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Clifford</creatorcontrib><creatorcontrib>Schwartz, Morton K.</creatorcontrib><creatorcontrib>Posner, Jerome B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fleisher, Martin</au><au>Wasserstrom, William R.</au><au>Schold, S. Clifford</au><au>Schwartz, Morton K.</au><au>Posner, Jerome B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactic dehydrogenase isoenzymes in the cerebrospinal fluid of patients with systemic cancer</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1981-06-01</date><risdate>1981</risdate><volume>47</volume><issue>11</issue><spage>2654</spage><epage>2659</epage><pages>2654-2659</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>Lactic dehydrogenase (LDH) isoenzymes were measured in the cerebrospinal fluid (CSF) in a group of patients suffering a variety of cancer‐related neurologic problems. LDH‐5 isoenzyme as a percentage of total LDH activity was abnormally elevated (above 10 to 15%) in leptomeningeal infiltration by carcinoma (breast carcinoma, lung carcinoma, and malignant melanoma) but not in other types of CNS metastases. Abnormal LDH isoenzyme patterns were also seen with CSF infections in which a granulocytic pleocytosis was present. In the absence of infection, an elevated LDH isoenzyme 5:1 ratio suggested leptomeningeal tumor and, when used with other CSF markers (beta‐glucuronidase and CEA), LDH isoenzymes aid in early detection of this metastatic neoplastic process. They may also help to differentiate leptomeningeal tumor from other chronic meningitides. Measurement of CSF markers also aids in assessing the effectiveness of treatment since marker levels often vary with the clinical course.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>7260857</pmid><doi>10.1002/1097-0142(19810601)47:11<2654::AID-CNCR2820471122>3.0.CO;2-Z</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer, 1981-06, Vol.47 (11), p.2654-2659 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Brain Neoplasms - diagnosis Brain Neoplasms - secondary Breast Neoplasms Carcinoembryonic Antigen - cerebrospinal fluid Female Glucuronidase - cerebrospinal fluid Humans Isoenzymes L-Lactate Dehydrogenase - cerebrospinal fluid Lung Neoplasms Male Melanoma Meningeal Neoplasms - diagnosis Meningeal Neoplasms - secondary |
| title | Lactic dehydrogenase isoenzymes in the cerebrospinal fluid of patients with systemic cancer |
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