The efficiency of pooling mRNA in microarray experiments

In a microarray experiment, messenger RNA samples are oftentimes pooled across subjects out of necessity, or in an effort to reduce the effect of biological variation. A basic problem in such experiments is to estimate the nominal expression levels of a large number of genes. Pooling samples will af...

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Veröffentlicht in:	Biostatistics (Oxford, England) England), 2003-07, Vol.4 (3), p.465-477
Hauptverfasser:	Kendziorski, C M, Zhang, Y, Lan, H, Attie, A D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Confidence Intervals Data Interpretation, Statistical Gene Expression Profiling - economics Gene Expression Profiling - methods Mice Oligonucleotide Array Sequence Analysis - economics Oligonucleotide Array Sequence Analysis - methods Polymerase Chain Reaction - methods Reproducibility of Results Research Design RNA, Messenger - analysis RNA, Messenger - metabolism
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