Pharmacokinetics of diltiazem and a new analogue, LR-A/113, in the conscious rat

Pharmacokinetics and metabolism of diltiazem and a new analogue, LR-A/113, have been studied in the rat. Conscious rats, with the jugular vein cannulated, received the compounds by intravenous (3 mg/kg body weight) or oral (50 mg/kg body weight) route. Parent compounds and their N-demethyl and N-dea...

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Veröffentlicht in:	European journal of drug metabolism and pharmacokinetics 1992-10, Vol.17 (4), p.269-274
Hauptverfasser:	BERNASCONI, R, CALIARI, S, LATINI, R, LEOPALDI, D, PORZIO, S, SALIMBENI, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiovascular system Consciousness Diltiazem - analogs & derivatives Diltiazem - pharmacokinetics Half-Life Male Medical sciences Miscellaneous Pharmacology. Drug treatments Rats Rats, Sprague-Dawley
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