HLA system affects the age‐at‐onset in chronic myeloid leukemia

Chronic myeloid leukemia (CML) occurs from childhood to old age. The adult form is characterized by the presence of Philadelphia chromosome resulting from bcr/abl translocation. The BCR–ABL fusion proteins are immunogenic, and the junctional sequences show unique HLA class I and class II restriction...

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Veröffentlicht in:	American journal of hematology 2003-08, Vol.73 (4), p.256-262
Hauptverfasser:	Oguz, Fatma Savran, Kalayoglu, Sevgi, Diler, A. Sarper, Tozkir, Hilmi, Sargin, Deniz, Carin, Mahmut, Dorak, M. Tevfik
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age of Onset Biological and medical sciences Case-Control Studies chronic myeloid leukemia Gene Frequency Genetic Predisposition to Disease genetic susceptibility Hematologic and hematopoietic diseases HLA Antigens - genetics HLA-A Antigens - genetics HLA-B Antigens - genetics HLA-DR Antigens - genetics HLA-DRB1 Chains HLA‐DR Homozygote Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - epidemiology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis major histocompatibility complex Medical sciences Middle Aged Odds Ratio Retrospective Studies Turkey - epidemiology
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