Fibrinolytic activity in women on oral contraceptive pills: Variation due to haemoglobin genotype
Plasma fibrinogen levels and euglobulin lysis time (ELT) were determined in 84 women with haemoglobin genotype AA (HbAA) and in 38 with haemoglobin genotype AS (HbAS), aged 17–35 years, who were on oral contraceptive pills (OCP). The control group included 23 HbAA and 27 HbAS age-matched, apparently...
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| Veröffentlicht in: | Acta tropica 1992-12, Vol.52 (2), p.135-138 |
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| creator | Famodu, A.A. Erhunmwunse, R.U. Elom, E.U. |
| description | Plasma fibrinogen levels and euglobulin lysis time (ELT) were determined in 84 women with haemoglobin genotype AA (HbAA) and in 38 with haemoglobin genotype AS (HbAS), aged 17–35 years, who were on oral contraceptive pills (OCP). The control group included 23 HbAA and 27 HbAS age-matched, apparently healthy women, who had regular menstruation and no history of OCP usage. The controls showed statistically significant elevations in fibrinogen levels in women with genotype HbAS (+ 13%;
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| doi_str_mv | 10.1016/0001-706X(92)90029-W |
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P<0.05) compared with women with genotype HbAA. Among OCP users, the difference in fibrinogen levels (+ 5%) between HbAS and HbAA women was not statistically significant. The elevation in fibrinogen levels which was restricted to the HbAA women, was probably caused by OCP use, and may be dependent on the Hb genotype. In contrast, the observed elevations in euglobulin lysis time among OCP users (
P<0.005) were independent of Hb genotype. Thus, while OCP may constitute a risk factor for the development of thromboembolism in women, the S-gene may confer partial protection against this development in women who have the HbAS genotype.</description><identifier>ISSN: 0001-706X</identifier><identifier>EISSN: 1873-6254</identifier><identifier>DOI: 10.1016/0001-706X(92)90029-W</identifier><identifier>PMID: 1363177</identifier><identifier>CODEN: ACTRAQ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Contraception ; Contraceptives, Oral - pharmacology ; Drug toxicity and drugs side effects treatment ; Female ; Fibrinogen - analysis ; Fibrinolysis - drug effects ; Fibrinolytic activity ; Genotype ; Hemoglobin A - genetics ; Hemoglobin AA, AS ; Hemoglobin, Sickle - genetics ; Humans ; Medical sciences ; Oral contraceptive pill ; Pharmacology. Drug treatments ; Population ; Risk Factors ; Toxicity: blood ; Tropical medicine</subject><ispartof>Acta tropica, 1992-12, Vol.52 (2), p.135-138</ispartof><rights>1992</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-e7ac5df67bd47aa7e72f317753156461baebf05801df244cf36ae13c6f94f04d3</citedby><cites>FETCH-LOGICAL-c441t-e7ac5df67bd47aa7e72f317753156461baebf05801df244cf36ae13c6f94f04d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0001706X9290029W$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4469045$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1363177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Famodu, A.A.</creatorcontrib><creatorcontrib>Erhunmwunse, R.U.</creatorcontrib><creatorcontrib>Elom, E.U.</creatorcontrib><title>Fibrinolytic activity in women on oral contraceptive pills: Variation due to haemoglobin genotype</title><title>Acta tropica</title><addtitle>Acta Trop</addtitle><description>Plasma fibrinogen levels and euglobulin lysis time (ELT) were determined in 84 women with haemoglobin genotype AA (HbAA) and in 38 with haemoglobin genotype AS (HbAS), aged 17–35 years, who were on oral contraceptive pills (OCP). The control group included 23 HbAA and 27 HbAS age-matched, apparently healthy women, who had regular menstruation and no history of OCP usage. The controls showed statistically significant elevations in fibrinogen levels in women with genotype HbAS (+ 13%;
P<0.05) compared with women with genotype HbAA. Among OCP users, the difference in fibrinogen levels (+ 5%) between HbAS and HbAA women was not statistically significant. The elevation in fibrinogen levels which was restricted to the HbAA women, was probably caused by OCP use, and may be dependent on the Hb genotype. In contrast, the observed elevations in euglobulin lysis time among OCP users (
P<0.005) were independent of Hb genotype. Thus, while OCP may constitute a risk factor for the development of thromboembolism in women, the S-gene may confer partial protection against this development in women who have the HbAS genotype.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Contraception</subject><subject>Contraceptives, Oral - pharmacology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Fibrinogen - analysis</subject><subject>Fibrinolysis - drug effects</subject><subject>Fibrinolytic activity</subject><subject>Genotype</subject><subject>Hemoglobin A - genetics</subject><subject>Hemoglobin AA, AS</subject><subject>Hemoglobin, Sickle - genetics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Oral contraceptive pill</subject><subject>Pharmacology. Drug treatments</subject><subject>Population</subject><subject>Risk Factors</subject><subject>Toxicity: blood</subject><subject>Tropical medicine</subject><issn>0001-706X</issn><issn>1873-6254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-LFDEQxYMo67j6DRRyENFDa_51su1BkMVVYcGLut5CdbqyRtKdNsmszLc34wzrTaGgKOr3HsUrQh5z9pIzrl8xxnhnmP72fBAvBsbE0F3dIRt-ZmSnRa_uks0tcp88KOVHm4TpxQk54VJLbsyGwEUYc1hS3NXgKLgabkLd0bDQX2nGhaZWGSJ1aakZHK4NQLqGGMtr-hVygBoaM22R1kS_A87pOqax6a9xSXW34kNyz0Ms-OjYT8mXi3efzz90l5_efzx_e9k5pXjt0IDrJ6_NOCkDYNAIvz-xl7zXSvMRcPSsP2N88kIp56UG5NJpPyjP1CRPybOD75rTzy2WaudQHMYIC6ZtsUaqobmp_4JSSGWMNg1UB9DlVEpGb9ccZsg7y5ndv8Du87X7fO0g7J8X2Ksme3L0344zTn9Fh8zb_ulxD8VB9BkWF8otppQemOob9uaAYQvtJmC2xQVcHE4ho6t2SuHfd_wGpv2kIQ</recordid><startdate>19921201</startdate><enddate>19921201</enddate><creator>Famodu, A.A.</creator><creator>Erhunmwunse, R.U.</creator><creator>Elom, E.U.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>19921201</creationdate><title>Fibrinolytic activity in women on oral contraceptive pills: Variation due to haemoglobin genotype</title><author>Famodu, A.A. ; Erhunmwunse, R.U. ; Elom, E.U.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-e7ac5df67bd47aa7e72f317753156461baebf05801df244cf36ae13c6f94f04d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Contraception</topic><topic>Contraceptives, Oral - pharmacology</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Fibrinogen - analysis</topic><topic>Fibrinolysis - drug effects</topic><topic>Fibrinolytic activity</topic><topic>Genotype</topic><topic>Hemoglobin A - genetics</topic><topic>Hemoglobin AA, AS</topic><topic>Hemoglobin, Sickle - genetics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Oral contraceptive pill</topic><topic>Pharmacology. Drug treatments</topic><topic>Population</topic><topic>Risk Factors</topic><topic>Toxicity: blood</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Famodu, A.A.</creatorcontrib><creatorcontrib>Erhunmwunse, R.U.</creatorcontrib><creatorcontrib>Elom, E.U.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Acta tropica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Famodu, A.A.</au><au>Erhunmwunse, R.U.</au><au>Elom, E.U.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fibrinolytic activity in women on oral contraceptive pills: Variation due to haemoglobin genotype</atitle><jtitle>Acta tropica</jtitle><addtitle>Acta Trop</addtitle><date>1992-12-01</date><risdate>1992</risdate><volume>52</volume><issue>2</issue><spage>135</spage><epage>138</epage><pages>135-138</pages><issn>0001-706X</issn><eissn>1873-6254</eissn><coden>ACTRAQ</coden><abstract>Plasma fibrinogen levels and euglobulin lysis time (ELT) were determined in 84 women with haemoglobin genotype AA (HbAA) and in 38 with haemoglobin genotype AS (HbAS), aged 17–35 years, who were on oral contraceptive pills (OCP). The control group included 23 HbAA and 27 HbAS age-matched, apparently healthy women, who had regular menstruation and no history of OCP usage. The controls showed statistically significant elevations in fibrinogen levels in women with genotype HbAS (+ 13%;
P<0.05) compared with women with genotype HbAA. Among OCP users, the difference in fibrinogen levels (+ 5%) between HbAS and HbAA women was not statistically significant. The elevation in fibrinogen levels which was restricted to the HbAA women, was probably caused by OCP use, and may be dependent on the Hb genotype. In contrast, the observed elevations in euglobulin lysis time among OCP users (
P<0.005) were independent of Hb genotype. Thus, while OCP may constitute a risk factor for the development of thromboembolism in women, the S-gene may confer partial protection against this development in women who have the HbAS genotype.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1363177</pmid><doi>10.1016/0001-706X(92)90029-W</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Contraception Contraceptives, Oral - pharmacology Drug toxicity and drugs side effects treatment Female Fibrinogen - analysis Fibrinolysis - drug effects Fibrinolytic activity Genotype Hemoglobin A - genetics Hemoglobin AA, AS Hemoglobin, Sickle - genetics Humans Medical sciences Oral contraceptive pill Pharmacology. Drug treatments Population Risk Factors Toxicity: blood Tropical medicine |
| title | Fibrinolytic activity in women on oral contraceptive pills: Variation due to haemoglobin genotype |
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