Concentration-dependent effects of mometasone furoate and dexamethasone on foetal lung fibroblast functions involved in airway inflammation and remodeling

Lung fibroblasts play a key role in the pathogenesis of airway inflammation and remodeling through the release of mediators and the expression of surface molecules connected with cell–cell and cell–extracellular matrix interaction. The aim of the study was to evaluate the inhibitory effect of two co...

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Veröffentlicht in:	Pulmonary pharmacology & therapeutics 2003-01, Vol.16 (5), p.287-297
Hauptverfasser:	Sabatini, F, Silvestri, M, Sale, R, Serpero, L, Giuliani, M, Scarso, L, Favini, P, Rossi, G.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion molecules Airway Obstruction - physiopathology Cell Adhesion Molecules - drug effects Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Line Chemokine CCL11 Chemokine CCL2 - metabolism Chemokines Chemokines, CC - metabolism Cytokines Dexamethasone - antagonists & inhibitors Dexamethasone - pharmacology DNA - biosynthesis DNA - drug effects DNA - metabolism Dose-Response Relationship, Drug Fibroblasts - drug effects Fibroblasts - physiology Humans Hyaluronan Receptors - drug effects Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Intercellular Adhesion Molecule-1 - drug effects Intercellular Adhesion Molecule-1 - metabolism Interleukin-6 - metabolism Lung - cytology Lung fibroblasts Mometasone Furoate Pregnadienediols - antagonists & inhibitors Pregnadienediols - pharmacology Transforming Growth Factor beta - drug effects Transforming Growth Factor beta - metabolism
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