A magnetic resonance imaging based method for measurement of tissue iron concentration in liver arterially embolized with ferrimagnetic particles designed for magnetic hyperthermia treatment of tumors
Rabbit liver was loaded with ferrimagnetic particles of γ -Fe 2 O 3 (designed for magnetic hyperthermia treatment of liver tumors) by injecting various doses of a suspension of the particles into the hepatic artery in vivo. Proton transverse relaxation rate (R 2) images of the livers in vivo, excise...
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| Veröffentlicht in: | Magnetic resonance imaging 2003-06, Vol.21 (5), p.483-488 |
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| creator | Pardoe, H Clark, P.R St. Pierre, T.G Moroz, P Jones, S.K |
| description | Rabbit liver was loaded with ferrimagnetic particles of γ -Fe
2 O
3 (designed for magnetic hyperthermia treatment of liver tumors) by injecting various doses of a suspension of the particles into the hepatic artery in vivo. Proton transverse relaxation rate (R
2) images of the livers in vivo, excised, and dissected were generated from a series of single spin-echo images. Mean R
2 values for samples of ferrimagnetic-particle-loaded liver dissected into approximate 1 cm cubes were found to linearly correlate with tissue iron concentration over the range from approximately 0.1 to at least 2.7 mg Fe/g dry tissue when measured at room temperature. Changing the temperature of ferrimagnetic-particle-loaded samples of liver from 1°C to 37°C had no observable effect on tissue R
2 values. However, a small but significant decrease in R
2 was found for control samples containing no ferrimagnetic material on raising the temperature from 1°C to 37°C. Both chemically measured iron concentrations and mean R
2 values for rabbit livers with implanted tumors tended to be higher than those measured for tumor-free liver. This study indicates that tissue R
2 measurement and imaging by nuclear magnetic resonance may have a useful role in magnetic hyperthermia therapy protocols for the treatment of liver cancer. |
| doi_str_mv | 10.1016/S0730-725X(03)00072-9 |
| format | Article |
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2 O
3 (designed for magnetic hyperthermia treatment of liver tumors) by injecting various doses of a suspension of the particles into the hepatic artery in vivo. Proton transverse relaxation rate (R
2) images of the livers in vivo, excised, and dissected were generated from a series of single spin-echo images. Mean R
2 values for samples of ferrimagnetic-particle-loaded liver dissected into approximate 1 cm cubes were found to linearly correlate with tissue iron concentration over the range from approximately 0.1 to at least 2.7 mg Fe/g dry tissue when measured at room temperature. Changing the temperature of ferrimagnetic-particle-loaded samples of liver from 1°C to 37°C had no observable effect on tissue R
2 values. However, a small but significant decrease in R
2 was found for control samples containing no ferrimagnetic material on raising the temperature from 1°C to 37°C. Both chemically measured iron concentrations and mean R
2 values for rabbit livers with implanted tumors tended to be higher than those measured for tumor-free liver. This study indicates that tissue R
2 measurement and imaging by nuclear magnetic resonance may have a useful role in magnetic hyperthermia therapy protocols for the treatment of liver cancer.</description><identifier>ISSN: 0730-725X</identifier><identifier>EISSN: 1873-5894</identifier><identifier>DOI: 10.1016/S0730-725X(03)00072-9</identifier><identifier>PMID: 12878257</identifier><identifier>CODEN: MRIMDQ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Embolization, Therapeutic - methods ; Ferric Compounds - administration & dosage ; Hyperthermia, Induced ; Iodized Oil - administration & dosage ; Iron - analysis ; Liver Neoplasms, Experimental - pathology ; Liver Neoplasms, Experimental - therapy ; Magnetic hyperthermia ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Medical sciences ; Rabbits ; T 2; R 2; Iron concentration ; Tumor</subject><ispartof>Magnetic resonance imaging, 2003-06, Vol.21 (5), p.483-488</ispartof><rights>2003 Elsevier Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-40e2faed65cc49163e4cc90422ab8bcab516884992bb2775dcae04cc19fb16693</citedby><cites>FETCH-LOGICAL-c391t-40e2faed65cc49163e4cc90422ab8bcab516884992bb2775dcae04cc19fb16693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0730-725X(03)00072-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15005007$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12878257$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pardoe, H</creatorcontrib><creatorcontrib>Clark, P.R</creatorcontrib><creatorcontrib>St. Pierre, T.G</creatorcontrib><creatorcontrib>Moroz, P</creatorcontrib><creatorcontrib>Jones, S.K</creatorcontrib><title>A magnetic resonance imaging based method for measurement of tissue iron concentration in liver arterially embolized with ferrimagnetic particles designed for magnetic hyperthermia treatment of tumors</title><title>Magnetic resonance imaging</title><addtitle>Magn Reson Imaging</addtitle><description>Rabbit liver was loaded with ferrimagnetic particles of γ -Fe
2 O
3 (designed for magnetic hyperthermia treatment of liver tumors) by injecting various doses of a suspension of the particles into the hepatic artery in vivo. Proton transverse relaxation rate (R
2) images of the livers in vivo, excised, and dissected were generated from a series of single spin-echo images. Mean R
2 values for samples of ferrimagnetic-particle-loaded liver dissected into approximate 1 cm cubes were found to linearly correlate with tissue iron concentration over the range from approximately 0.1 to at least 2.7 mg Fe/g dry tissue when measured at room temperature. Changing the temperature of ferrimagnetic-particle-loaded samples of liver from 1°C to 37°C had no observable effect on tissue R
2 values. However, a small but significant decrease in R
2 was found for control samples containing no ferrimagnetic material on raising the temperature from 1°C to 37°C. Both chemically measured iron concentrations and mean R
2 values for rabbit livers with implanted tumors tended to be higher than those measured for tumor-free liver. This study indicates that tissue R
2 measurement and imaging by nuclear magnetic resonance may have a useful role in magnetic hyperthermia therapy protocols for the treatment of liver cancer.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Embolization, Therapeutic - methods</subject><subject>Ferric Compounds - administration & dosage</subject><subject>Hyperthermia, Induced</subject><subject>Iodized Oil - administration & dosage</subject><subject>Iron - analysis</subject><subject>Liver Neoplasms, Experimental - pathology</subject><subject>Liver Neoplasms, Experimental - therapy</subject><subject>Magnetic hyperthermia</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical sciences</subject><subject>Rabbits</subject><subject>T 2; R 2; Iron concentration</subject><subject>Tumor</subject><issn>0730-725X</issn><issn>1873-5894</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAQgCMEokvhEUC-gOAQsJ04jk-oqviTKnEAJG6W40y6g5J4GTtFyxPyWHi7YXvkZHv8zY_9FcVTwV8LLpo3X7iueKml-v6SV68451qW5l6xEa2uStWa-n6xOSFnxaMYf2RIyUo9LM6EbHUrld4Ufy7Y5K5nSOgZQQyzmz0wzDGcr1nnIvRsgrQNPRsC5a2LC8EEc2JhYAljXDJOYWY-5Mw5kUuYTzizEW-AmKMEhG4c9wymLoz4O1f8hWnLBiDCU_NdBtGPEFkPEXNwbfjvfrvfAaUt0ISOJQKXTkMsU6D4uHgwuDHCk3U9L769f_f18mN59fnDp8uLq9JXRqSy5iAHB32jvK-NaCqovTe8ltJ1beddp0TTtrUxsuuk1qr3DnhGhBk60TSmOi9eHOvuKPxcICY7YfQwjm6GsESrq9rUWtcZVEfQU4iRYLC7w3NpbwW3B4X2VqE9-LG8srcK7aHBs7XB0k3Q32WtzjLwfAVc9G4cKCvDeMeprDnXytzbIwf5O24QyEaPkCX1SOCT7QP-Z5S_rMu_zg</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Pardoe, H</creator><creator>Clark, P.R</creator><creator>St. Pierre, T.G</creator><creator>Moroz, P</creator><creator>Jones, S.K</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>A magnetic resonance imaging based method for measurement of tissue iron concentration in liver arterially embolized with ferrimagnetic particles designed for magnetic hyperthermia treatment of tumors</title><author>Pardoe, H ; Clark, P.R ; St. Pierre, T.G ; Moroz, P ; Jones, S.K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-40e2faed65cc49163e4cc90422ab8bcab516884992bb2775dcae04cc19fb16693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Embolization, Therapeutic - methods</topic><topic>Ferric Compounds - administration & dosage</topic><topic>Hyperthermia, Induced</topic><topic>Iodized Oil - administration & dosage</topic><topic>Iron - analysis</topic><topic>Liver Neoplasms, Experimental - pathology</topic><topic>Liver Neoplasms, Experimental - therapy</topic><topic>Magnetic hyperthermia</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical sciences</topic><topic>Rabbits</topic><topic>T 2; R 2; Iron concentration</topic><topic>Tumor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pardoe, H</creatorcontrib><creatorcontrib>Clark, P.R</creatorcontrib><creatorcontrib>St. Pierre, T.G</creatorcontrib><creatorcontrib>Moroz, P</creatorcontrib><creatorcontrib>Jones, S.K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pardoe, H</au><au>Clark, P.R</au><au>St. Pierre, T.G</au><au>Moroz, P</au><au>Jones, S.K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A magnetic resonance imaging based method for measurement of tissue iron concentration in liver arterially embolized with ferrimagnetic particles designed for magnetic hyperthermia treatment of tumors</atitle><jtitle>Magnetic resonance imaging</jtitle><addtitle>Magn Reson Imaging</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>21</volume><issue>5</issue><spage>483</spage><epage>488</epage><pages>483-488</pages><issn>0730-725X</issn><eissn>1873-5894</eissn><coden>MRIMDQ</coden><abstract>Rabbit liver was loaded with ferrimagnetic particles of γ -Fe
2 O
3 (designed for magnetic hyperthermia treatment of liver tumors) by injecting various doses of a suspension of the particles into the hepatic artery in vivo. Proton transverse relaxation rate (R
2) images of the livers in vivo, excised, and dissected were generated from a series of single spin-echo images. Mean R
2 values for samples of ferrimagnetic-particle-loaded liver dissected into approximate 1 cm cubes were found to linearly correlate with tissue iron concentration over the range from approximately 0.1 to at least 2.7 mg Fe/g dry tissue when measured at room temperature. Changing the temperature of ferrimagnetic-particle-loaded samples of liver from 1°C to 37°C had no observable effect on tissue R
2 values. However, a small but significant decrease in R
2 was found for control samples containing no ferrimagnetic material on raising the temperature from 1°C to 37°C. Both chemically measured iron concentrations and mean R
2 values for rabbit livers with implanted tumors tended to be higher than those measured for tumor-free liver. This study indicates that tissue R
2 measurement and imaging by nuclear magnetic resonance may have a useful role in magnetic hyperthermia therapy protocols for the treatment of liver cancer.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12878257</pmid><doi>10.1016/S0730-725X(03)00072-9</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Magnetic resonance imaging, 2003-06, Vol.21 (5), p.483-488 |
| issn | 0730-725X 1873-5894 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Embolization, Therapeutic - methods Ferric Compounds - administration & dosage Hyperthermia, Induced Iodized Oil - administration & dosage Iron - analysis Liver Neoplasms, Experimental - pathology Liver Neoplasms, Experimental - therapy Magnetic hyperthermia Magnetic resonance imaging Magnetic Resonance Imaging - methods Medical sciences Rabbits T 2 R 2 Iron concentration Tumor |
| title | A magnetic resonance imaging based method for measurement of tissue iron concentration in liver arterially embolized with ferrimagnetic particles designed for magnetic hyperthermia treatment of tumors |
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