Memory training alters hippocampal neurochemistry in healthy elderly
Accumulating epidemiological evidence supports the notion of brain reserve, but there has been no investigation of neurobiological change associated with brief mental activation training in humans. Healthy older individuals were therefore investigated with magnetic resonance spectroscopy (MRS) in di...
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| Veröffentlicht in: | Neuroreport 2003-07, Vol.14 (10), p.1333-1337 |
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| creator | VALENZUELA, Michael J JONES, Megan WEI WEN RAE, Caroline GRAHAM, Scott SHNIER, Ronald SACHDEV, Perminder |
| description | Accumulating epidemiological evidence supports the notion of brain reserve, but there has been no investigation of neurobiological change associated with brief mental activation training in humans. Healthy older individuals were therefore investigated with magnetic resonance spectroscopy (MRS) in different brain regions before and after 5 weeks of focused memory training. Recall of a test-word list of > 23 items was achieved accompanied by elevation of creatine and choline signals in the hippocampus. Those at risk for neural dysfunction, as indicated by lower neurometabolites at baseline, demonstrated the largest MRS increases after training. Biochemical changes related to cellular energy and cell-membrane turnover were found to increase after structured memory exercises and were limited to the medial temporal lobe. |
| doi_str_mv | 10.1097/00001756-200307180-00010 |
| format | Article |
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Healthy older individuals were therefore investigated with magnetic resonance spectroscopy (MRS) in different brain regions before and after 5 weeks of focused memory training. Recall of a test-word list of > 23 items was achieved accompanied by elevation of creatine and choline signals in the hippocampus. Those at risk for neural dysfunction, as indicated by lower neurometabolites at baseline, demonstrated the largest MRS increases after training. Biochemical changes related to cellular energy and cell-membrane turnover were found to increase after structured memory exercises and were limited to the medial temporal lobe.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-200307180-00010</identifier><identifier>PMID: 12876468</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams and Wilkins</publisher><subject>Aged ; Aged, 80 and over ; Aging - physiology ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Biological and medical sciences ; Brain Chemistry ; Brain Mapping ; Cerebral Cortex - anatomy & histology ; Cerebral Cortex - chemistry ; Cerebral Cortex - metabolism ; Choline - metabolism ; Creatine - metabolism ; Development. Senescence. Regeneration. Transplantation ; Fundamental and applied biological sciences. Psychology ; Hippocampus - chemistry ; Hippocampus - cytology ; Hippocampus - metabolism ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Memory - physiology ; Mental Recall - physiology ; Middle Aged ; Practice (Psychology) ; Vertebrates: nervous system and sense organs ; Water - metabolism</subject><ispartof>Neuroreport, 2003-07, Vol.14 (10), p.1333-1337</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-67c7a5700685048f75d2eb18af7179c3f4c5ac228a62e3783b71027a5b4426053</citedby><cites>FETCH-LOGICAL-c353t-67c7a5700685048f75d2eb18af7179c3f4c5ac228a62e3783b71027a5b4426053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15060112$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12876468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VALENZUELA, Michael J</creatorcontrib><creatorcontrib>JONES, Megan</creatorcontrib><creatorcontrib>WEI WEN</creatorcontrib><creatorcontrib>RAE, Caroline</creatorcontrib><creatorcontrib>GRAHAM, Scott</creatorcontrib><creatorcontrib>SHNIER, Ronald</creatorcontrib><creatorcontrib>SACHDEV, Perminder</creatorcontrib><title>Memory training alters hippocampal neurochemistry in healthy elderly</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>Accumulating epidemiological evidence supports the notion of brain reserve, but there has been no investigation of neurobiological change associated with brief mental activation training in humans. Healthy older individuals were therefore investigated with magnetic resonance spectroscopy (MRS) in different brain regions before and after 5 weeks of focused memory training. Recall of a test-word list of > 23 items was achieved accompanied by elevation of creatine and choline signals in the hippocampus. Those at risk for neural dysfunction, as indicated by lower neurometabolites at baseline, demonstrated the largest MRS increases after training. Biochemical changes related to cellular energy and cell-membrane turnover were found to increase after structured memory exercises and were limited to the medial temporal lobe.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain Chemistry</subject><subject>Brain Mapping</subject><subject>Cerebral Cortex - anatomy & histology</subject><subject>Cerebral Cortex - chemistry</subject><subject>Cerebral Cortex - metabolism</subject><subject>Choline - metabolism</subject><subject>Creatine - metabolism</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus - chemistry</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - metabolism</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Memory - physiology</subject><subject>Mental Recall - physiology</subject><subject>Middle Aged</subject><subject>Practice (Psychology)</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Water - metabolism</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqXwCygb2AXGb2eJylMqYgMSu8hxHRLkPLCTRf4elxa6ZDYjjc6dGR2EEgxXGDJ5DbGw5CIlABQkVpBuJnCA5phJmnKu3g_RHDKepSwTfIZOQviMSAZYHaMZJkoKJtQc3T7bpvNTMnhdt3X7kWg3WB-Squ77zuim1y5p7eg7U9mmDkNE6zapbMSqKbFubb2bTtFRqV2wZ7u-QG_3d6_Lx3T18vC0vFmlhnI6pEIaqbkEEIoDU6Xka2ILrHQpscwMLZnh2hCitCCWSkULiYHESMEYEcDpAl1u9_a--xptGPL4krHO6dZ2Y8glZRnjgv0LEohWJMURVFvQ-C4Eb8u893Wj_ZRjyDeq81_V-Z_q_Ed1jJ7vboxFY9f74M5tBC52gA5Gu9Lr1tRhz3EQgDGh30ymhXU</recordid><startdate>20030718</startdate><enddate>20030718</enddate><creator>VALENZUELA, Michael J</creator><creator>JONES, Megan</creator><creator>WEI WEN</creator><creator>RAE, Caroline</creator><creator>GRAHAM, Scott</creator><creator>SHNIER, Ronald</creator><creator>SACHDEV, Perminder</creator><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20030718</creationdate><title>Memory training alters hippocampal neurochemistry in healthy elderly</title><author>VALENZUELA, Michael J ; JONES, Megan ; WEI WEN ; RAE, Caroline ; GRAHAM, Scott ; SHNIER, Ronald ; SACHDEV, Perminder</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-67c7a5700685048f75d2eb18af7179c3f4c5ac228a62e3783b71027a5b4426053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - physiology</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain Chemistry</topic><topic>Brain Mapping</topic><topic>Cerebral Cortex - anatomy & histology</topic><topic>Cerebral Cortex - chemistry</topic><topic>Cerebral Cortex - metabolism</topic><topic>Choline - metabolism</topic><topic>Creatine - metabolism</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Fundamental and applied biological sciences. 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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aged Aged, 80 and over Aging - physiology Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Biological and medical sciences Brain Chemistry Brain Mapping Cerebral Cortex - anatomy & histology Cerebral Cortex - chemistry Cerebral Cortex - metabolism Choline - metabolism Creatine - metabolism Development. Senescence. Regeneration. Transplantation Fundamental and applied biological sciences. Psychology Hippocampus - chemistry Hippocampus - cytology Hippocampus - metabolism Humans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Memory - physiology Mental Recall - physiology Middle Aged Practice (Psychology) Vertebrates: nervous system and sense organs Water - metabolism |
| title | Memory training alters hippocampal neurochemistry in healthy elderly |
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