Cyclosporine A and Tacrolimus: In vitro investigations on the differential interactions with the cytochrome P450 system in rat and human liver

Species differences in the interactions of cyclosporine A (CSA) and tacrolimus (TAC) with the cytochrome P450 (CYP) system in male rat and human liver were investigated in vitro by assessing effects on a series of model reactions for different CYP isoforms. CSA and TAC concentration dependently inhi...

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Veröffentlicht in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2003-06, Vol.54 (5), p.467-473
Hauptverfasser:	Lupp, Amelie, Kuhn, Urs Dieter, Herwig, Roland, Karge, Elke, Rost, Michael, Scheele, Johannes, Fleck, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Outbred Strains Biological and medical sciences Cyclosporine - pharmacology Cyclosporine A Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism cytochrome P450 Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology human Humans Immunomodulators Immunosuppressive Agents - pharmacology Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Liver - drug effects Liver - enzymology Male Medical sciences Pharmacology. Drug treatments rat Rats Rats, Wistar Ribosomal Proteins - drug effects Ribosomal Proteins - metabolism species differences Species Specificity tacrolimus Tacrolimus - pharmacology
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