Cholesterol and the risk of renal dysfunction in apparently healthy men
Despite extensive knowledge about abnormal lipid patterns in patients with end-stage renal disease, the association between cholesterol and the development of renal dysfunction is unclear. We evaluated this association in a prospective cohort study among 4,483 initially healthy men participating in...
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| Veröffentlicht in: | Journal of the American Society of Nephrology 2003-08, Vol.14 (8), p.2084-2091 |
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| container_issue | 8 |
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| container_title | Journal of the American Society of Nephrology |
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| creator | Schaeffner, Elke S Kurth, Tobias Curhan, Gary C Glynn, Robert J Rexrode, Kathryn M Baigent, Colin Buring, Julie E Gaziano, J Michael |
| description | Despite extensive knowledge about abnormal lipid patterns in patients with end-stage renal disease, the association between cholesterol and the development of renal dysfunction is unclear. We evaluated this association in a prospective cohort study among 4,483 initially healthy men participating in the Physicians' Health Study who provided blood samples in 1982 and 1996. Main outcome measures were elevated creatinine, defined as >/= 1.5 mg/dl (133 micromol/L), and reduced estimated creatinine clearance, defined as /= 240 mg/dl, 2.16 (95% CI, 1.42 to 3.27) for HDL /= >6.8), and 2.16 (95% CI, 1.22 to 3.80) for the highest quartile of non-HDL cholesterol (>/= 196.1). Similar although smaller associations were observed between cholesterol parameters and reduced creatinine clearance. Elevated total cholesterol, high non-HDL cholesterol, a high ratio of total cholesterol/HDL, and low HDL in particular were significantly associated with an increased risk of developing renal dysfunction in men with an initial creatinine |
| doi_str_mv | 10.1681/ASN.V1482084 |
| format | Article |
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We evaluated this association in a prospective cohort study among 4,483 initially healthy men participating in the Physicians' Health Study who provided blood samples in 1982 and 1996. Main outcome measures were elevated creatinine, defined as >/= 1.5 mg/dl (133 micromol/L), and reduced estimated creatinine clearance, defined as </=55 ml/min. Cholesterol parameters included total cholesterol (<200, 200 to 239, and >/= 240 mg/dl), HDL (<40 or >/= 40 mg/dl), total non-HDL cholesterol, and the ratio of total cholesterol to HDL. We used logistic regression to calculate age- and multivariable adjusted odds ratios as a measure for the relative risk. After 14 yr, 134 men (3.0%) had elevated creatinine and 244 (5.4%) had reduced creatinine clearance. The multivariable relative risk for elevated creatinine was 1.77 (95% confidence interval [CI], 1.10 to 2.86) for total cholesterol >/= 240 mg/dl, 2.16 (95% CI, 1.42 to 3.27) for HDL <40 mg/dl, 2.34 (95% CI, 1.34 to 4.07) for the highest quartile of total cholesterol/HDL ratio (>/= >6.8), and 2.16 (95% CI, 1.22 to 3.80) for the highest quartile of non-HDL cholesterol (>/= 196.1). Similar although smaller associations were observed between cholesterol parameters and reduced creatinine clearance. Elevated total cholesterol, high non-HDL cholesterol, a high ratio of total cholesterol/HDL, and low HDL in particular were significantly associated with an increased risk of developing renal dysfunction in men with an initial creatinine <1.5 mg/dl.</description><identifier>ISSN: 1046-6673</identifier><identifier>DOI: 10.1681/ASN.V1482084</identifier><identifier>PMID: 12874462</identifier><language>eng</language><publisher>United States</publisher><subject>Cholesterol - metabolism ; Cholesterol, HDL - metabolism ; Cohort Studies ; Creatinine - blood ; Creatinine - metabolism ; Edetic Acid - chemistry ; Glomerular Filtration Rate ; Humans ; Kidney Diseases - diagnosis ; Kidney Diseases - pathology ; Kidney Failure, Chronic - metabolism ; Lipid Metabolism ; Logistic Models ; Male ; Multivariate Analysis ; Odds Ratio ; Prospective Studies ; Risk ; Time Factors ; Treatment Outcome</subject><ispartof>Journal of the American Society of Nephrology, 2003-08, Vol.14 (8), p.2084-2091</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-e2e5b6bb6857c1683a64bb5e1294cb928def802f9fb1a41f3bb4b8aeb88b14153</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12874462$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schaeffner, Elke S</creatorcontrib><creatorcontrib>Kurth, Tobias</creatorcontrib><creatorcontrib>Curhan, Gary C</creatorcontrib><creatorcontrib>Glynn, Robert J</creatorcontrib><creatorcontrib>Rexrode, Kathryn M</creatorcontrib><creatorcontrib>Baigent, Colin</creatorcontrib><creatorcontrib>Buring, Julie E</creatorcontrib><creatorcontrib>Gaziano, J Michael</creatorcontrib><title>Cholesterol and the risk of renal dysfunction in apparently healthy men</title><title>Journal of the American Society of Nephrology</title><addtitle>J Am Soc Nephrol</addtitle><description>Despite extensive knowledge about abnormal lipid patterns in patients with end-stage renal disease, the association between cholesterol and the development of renal dysfunction is unclear. We evaluated this association in a prospective cohort study among 4,483 initially healthy men participating in the Physicians' Health Study who provided blood samples in 1982 and 1996. Main outcome measures were elevated creatinine, defined as >/= 1.5 mg/dl (133 micromol/L), and reduced estimated creatinine clearance, defined as </=55 ml/min. Cholesterol parameters included total cholesterol (<200, 200 to 239, and >/= 240 mg/dl), HDL (<40 or >/= 40 mg/dl), total non-HDL cholesterol, and the ratio of total cholesterol to HDL. We used logistic regression to calculate age- and multivariable adjusted odds ratios as a measure for the relative risk. After 14 yr, 134 men (3.0%) had elevated creatinine and 244 (5.4%) had reduced creatinine clearance. The multivariable relative risk for elevated creatinine was 1.77 (95% confidence interval [CI], 1.10 to 2.86) for total cholesterol >/= 240 mg/dl, 2.16 (95% CI, 1.42 to 3.27) for HDL <40 mg/dl, 2.34 (95% CI, 1.34 to 4.07) for the highest quartile of total cholesterol/HDL ratio (>/= >6.8), and 2.16 (95% CI, 1.22 to 3.80) for the highest quartile of non-HDL cholesterol (>/= 196.1). Similar although smaller associations were observed between cholesterol parameters and reduced creatinine clearance. Elevated total cholesterol, high non-HDL cholesterol, a high ratio of total cholesterol/HDL, and low HDL in particular were significantly associated with an increased risk of developing renal dysfunction in men with an initial creatinine <1.5 mg/dl.</description><subject>Cholesterol - metabolism</subject><subject>Cholesterol, HDL - metabolism</subject><subject>Cohort Studies</subject><subject>Creatinine - blood</subject><subject>Creatinine - metabolism</subject><subject>Edetic Acid - chemistry</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Kidney Diseases - diagnosis</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney Failure, Chronic - metabolism</subject><subject>Lipid Metabolism</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Prospective Studies</subject><subject>Risk</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1046-6673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDtPwzAUhT2AaClszMgTEym24zjOWFVQkCoYeKyWnVwrAeeBnQz59xi1iOkO59PRuR9CV5SsqZD0bvP6vP6gXDIi-QlaUsJFIkSeLtB5CJ-E0Izl-RlaUCZzzgVbot227h2EEXzvsO4qPNaAfRO-cG-xh047XM3BTl05Nn2Hmw7rYdAxGN2Ma9BurGfcQneBTq12AS6Pd4XeH-7fto_J_mX3tN3sk5KnfEyAQWaEMUJmeRknp1pwYzKgrOClKZiswErCbGEN1Zza1BhupAYjpaGcZukK3Rx6B99_T3G4aptQgnO6g34KKk95Ed8UEbw9gKXvQ_Bg1eCbVvtZUaJ-ZakoS_3Jivj1sXcyLVT_8NFU-gObMWds</recordid><startdate>200308</startdate><enddate>200308</enddate><creator>Schaeffner, Elke S</creator><creator>Kurth, Tobias</creator><creator>Curhan, Gary C</creator><creator>Glynn, Robert J</creator><creator>Rexrode, Kathryn M</creator><creator>Baigent, Colin</creator><creator>Buring, Julie E</creator><creator>Gaziano, J Michael</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200308</creationdate><title>Cholesterol and the risk of renal dysfunction in apparently healthy men</title><author>Schaeffner, Elke S ; Kurth, Tobias ; Curhan, Gary C ; Glynn, Robert J ; Rexrode, Kathryn M ; Baigent, Colin ; Buring, Julie E ; Gaziano, J Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-e2e5b6bb6857c1683a64bb5e1294cb928def802f9fb1a41f3bb4b8aeb88b14153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Cholesterol - metabolism</topic><topic>Cholesterol, HDL - metabolism</topic><topic>Cohort Studies</topic><topic>Creatinine - blood</topic><topic>Creatinine - metabolism</topic><topic>Edetic Acid - chemistry</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Kidney Diseases - diagnosis</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney Failure, Chronic - metabolism</topic><topic>Lipid Metabolism</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Prospective Studies</topic><topic>Risk</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schaeffner, Elke S</creatorcontrib><creatorcontrib>Kurth, Tobias</creatorcontrib><creatorcontrib>Curhan, Gary C</creatorcontrib><creatorcontrib>Glynn, Robert J</creatorcontrib><creatorcontrib>Rexrode, Kathryn M</creatorcontrib><creatorcontrib>Baigent, Colin</creatorcontrib><creatorcontrib>Buring, Julie E</creatorcontrib><creatorcontrib>Gaziano, J Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Society of Nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schaeffner, Elke S</au><au>Kurth, Tobias</au><au>Curhan, Gary C</au><au>Glynn, Robert J</au><au>Rexrode, Kathryn M</au><au>Baigent, Colin</au><au>Buring, Julie E</au><au>Gaziano, J Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cholesterol and the risk of renal dysfunction in apparently healthy men</atitle><jtitle>Journal of the American Society of Nephrology</jtitle><addtitle>J Am Soc Nephrol</addtitle><date>2003-08</date><risdate>2003</risdate><volume>14</volume><issue>8</issue><spage>2084</spage><epage>2091</epage><pages>2084-2091</pages><issn>1046-6673</issn><abstract>Despite extensive knowledge about abnormal lipid patterns in patients with end-stage renal disease, the association between cholesterol and the development of renal dysfunction is unclear. We evaluated this association in a prospective cohort study among 4,483 initially healthy men participating in the Physicians' Health Study who provided blood samples in 1982 and 1996. Main outcome measures were elevated creatinine, defined as >/= 1.5 mg/dl (133 micromol/L), and reduced estimated creatinine clearance, defined as </=55 ml/min. Cholesterol parameters included total cholesterol (<200, 200 to 239, and >/= 240 mg/dl), HDL (<40 or >/= 40 mg/dl), total non-HDL cholesterol, and the ratio of total cholesterol to HDL. We used logistic regression to calculate age- and multivariable adjusted odds ratios as a measure for the relative risk. After 14 yr, 134 men (3.0%) had elevated creatinine and 244 (5.4%) had reduced creatinine clearance. The multivariable relative risk for elevated creatinine was 1.77 (95% confidence interval [CI], 1.10 to 2.86) for total cholesterol >/= 240 mg/dl, 2.16 (95% CI, 1.42 to 3.27) for HDL <40 mg/dl, 2.34 (95% CI, 1.34 to 4.07) for the highest quartile of total cholesterol/HDL ratio (>/= >6.8), and 2.16 (95% CI, 1.22 to 3.80) for the highest quartile of non-HDL cholesterol (>/= 196.1). Similar although smaller associations were observed between cholesterol parameters and reduced creatinine clearance. Elevated total cholesterol, high non-HDL cholesterol, a high ratio of total cholesterol/HDL, and low HDL in particular were significantly associated with an increased risk of developing renal dysfunction in men with an initial creatinine <1.5 mg/dl.</abstract><cop>United States</cop><pmid>12874462</pmid><doi>10.1681/ASN.V1482084</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Cholesterol - metabolism Cholesterol, HDL - metabolism Cohort Studies Creatinine - blood Creatinine - metabolism Edetic Acid - chemistry Glomerular Filtration Rate Humans Kidney Diseases - diagnosis Kidney Diseases - pathology Kidney Failure, Chronic - metabolism Lipid Metabolism Logistic Models Male Multivariate Analysis Odds Ratio Prospective Studies Risk Time Factors Treatment Outcome |
| title | Cholesterol and the risk of renal dysfunction in apparently healthy men |
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