Sphingosine kinase modulates microvascular tone and myogenic responses through activation of RhoA/Rho kinase

RhoA and Rho kinase are important modulators of microvascular tone. We tested whether sphingosine kinase (Sphk1) that generates the endogenous sphingolipid mediator sphingosine-1-phosphate (S1P) is part of a signaling cascade to activate the RhoA/Rho kinase pathway. Using a new transfection model, w...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2003-07, Vol.108 (3), p.342-347
Hauptverfasser:	BOLZ, Steffen-Sebastian, VOGEL, Lukas, SOLLINGER, Daniel, DERWAND, Roland, BOER, Christa, PITSON, Stuart M, SPIEGEL, Sarah, POHL, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteries - cytology Arteries - drug effects Arteries - physiology Biological and medical sciences Blood vessels and receptors Cricetinae Culture Techniques Enzyme Activation - physiology Fundamental and applied biological sciences. Psychology Genes, Dominant Green Fluorescent Proteins Intracellular Signaling Peptides and Proteins Luminescent Proteins - genetics Microcirculation - physiology Muscle, Skeletal - blood supply Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Phosphotransferases (Alcohol Group Acceptor) - biosynthesis Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - physiology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism rho-Associated Kinases rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism Signal Transduction - physiology Transfection Vasoconstriction - physiology Vasomotor System - physiology Vertebrates: cardiovascular system
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