Systemic anaphylaxis is prevented in alloxan-diabetic rats by a mechanism dependent on glucocorticoids
This study was undertaken to examine whether glucocorticoids could be implicated in the hyporesponsiveness of diabetic rats to systemic anaphylaxis. Rats were actively sensitized with a mixture of Al(OH) 3 plus ovalbumin and challenged i.v. with ovalbumin 14 days later. Diabetes was induced by allox...
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| Veröffentlicht in: | European journal of pharmacology 2003-07, Vol.472 (3), p.221-227 |
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| container_title | European journal of pharmacology |
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| creator | Carvalho, Vinicius F. Barreto, Emiliano O. Diaz, Bruno L. Serra, Magda F. Azevedo, Viviane Cordeiro, Renato S.B. Martins, Marco A. e Silva, Patrı́ cia M.R. |
| description | This study was undertaken to examine whether glucocorticoids could be implicated in the hyporesponsiveness of diabetic rats to systemic anaphylaxis. Rats were actively sensitized with a mixture of Al(OH)
3 plus ovalbumin and challenged i.v. with ovalbumin 14 days later. Diabetes was induced by alloxan-injected i.v. either before or after sensitization. Elevation of total and specific serum immunoglobulin E (IgE) was abolished in rats turned diabetic and then sensitised, but not in those first sensitised and then turned diabetic. In both conditions, increased serum corticosterone levels occurred in parallel with protection of diabetic animals against fatal shock, intestinal haemorrhage and elevation in plasma histamine levels evoked by antigen challenge. The resistance of diabetic rats to fatal shock was no longer significantly different from that of non-diabetic rats following treatment with the glucocorticoid receptor antagonist RU 486 (mifepristone). These findings indicate that endogenous glucocorticoid plays a pivotal role in the phenomenon of hyporeactivity to systemic anaphylaxis in alloxan-diabetic rats. |
| doi_str_mv | 10.1016/S0014-2999(03)01934-4 |
| format | Article |
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3 plus ovalbumin and challenged i.v. with ovalbumin 14 days later. Diabetes was induced by alloxan-injected i.v. either before or after sensitization. Elevation of total and specific serum immunoglobulin E (IgE) was abolished in rats turned diabetic and then sensitised, but not in those first sensitised and then turned diabetic. In both conditions, increased serum corticosterone levels occurred in parallel with protection of diabetic animals against fatal shock, intestinal haemorrhage and elevation in plasma histamine levels evoked by antigen challenge. The resistance of diabetic rats to fatal shock was no longer significantly different from that of non-diabetic rats following treatment with the glucocorticoid receptor antagonist RU 486 (mifepristone). These findings indicate that endogenous glucocorticoid plays a pivotal role in the phenomenon of hyporeactivity to systemic anaphylaxis in alloxan-diabetic rats.</description><subject>Anaphylaxis - blood</subject><subject>Anaphylaxis - prevention & control</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Glucocorticoid</subject><subject>Glucocorticoids - blood</subject><subject>Male</subject><subject>Mast cell</subject><subject>Medical sciences</subject><subject>Mifepristone - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Glucocorticoid - antagonists & inhibitors</subject><subject>Receptors, Glucocorticoid - metabolism</subject><subject>Systemic anaphylaxis</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFLHTEQx0Op1KftR1ByadHDtskm2SQnKaK2IHiwPYdsMqspu8ma7BPftzf6HvUoZAgMv__M8EPoiJLvlNDuxy0hlDet1vqEsFNCNeMN_4BWVEndEEnbj2j1H9lHB6X8I4QI3YpPaJ-2SlIp5AoNt5uywBQcttHO95vRPoWC65szPEJcwOMQsR3H9GRj44PtYalwtkvB_QZbPIG7tzGUCXuYIfqawSniu3Htkku5win48hntDXYs8GX3H6K_lxd_zn811zdXv89_XjeOc7Y0th2oUE6RvmOgNaPEeeZ6xTulBeFe6KHtRO1qpohunawmOq86rnsqWyvYIfq2nTvn9LCGspgpFAfjaCOkdTGScSW0lhUUW9DlVEqGwcw5TDZvDCXmRbB5FWxe7BnCzKtgw2vueLdg3U_g31I7oxX4ugNscXYcso0ulDeOa16LVu5sy0HV8Rggm-ICRAc-ZHCL8Sm8c8ozGKeXsg</recordid><startdate>20030711</startdate><enddate>20030711</enddate><creator>Carvalho, Vinicius F.</creator><creator>Barreto, Emiliano O.</creator><creator>Diaz, Bruno L.</creator><creator>Serra, Magda F.</creator><creator>Azevedo, Viviane</creator><creator>Cordeiro, Renato S.B.</creator><creator>Martins, Marco A.</creator><creator>e Silva, Patrı&#x0301;cia M.R.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030711</creationdate><title>Systemic anaphylaxis is prevented in alloxan-diabetic rats by a mechanism dependent on glucocorticoids</title><author>Carvalho, Vinicius F. ; Barreto, Emiliano O. ; Diaz, Bruno L. ; Serra, Magda F. ; Azevedo, Viviane ; Cordeiro, Renato S.B. ; Martins, Marco A. ; e Silva, Patrı&#x0301;cia M.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-a2f158c80b63e99310cd3cb84689504d59f26510c938092c70166d8649b172a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Anaphylaxis - blood</topic><topic>Anaphylaxis - prevention & control</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Glucocorticoid</topic><topic>Glucocorticoids - blood</topic><topic>Male</topic><topic>Mast cell</topic><topic>Medical sciences</topic><topic>Mifepristone - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Glucocorticoid - antagonists & inhibitors</topic><topic>Receptors, Glucocorticoid - metabolism</topic><topic>Systemic anaphylaxis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carvalho, Vinicius F.</creatorcontrib><creatorcontrib>Barreto, Emiliano O.</creatorcontrib><creatorcontrib>Diaz, Bruno L.</creatorcontrib><creatorcontrib>Serra, Magda F.</creatorcontrib><creatorcontrib>Azevedo, Viviane</creatorcontrib><creatorcontrib>Cordeiro, Renato S.B.</creatorcontrib><creatorcontrib>Martins, Marco A.</creatorcontrib><creatorcontrib>e Silva, Patrı&#x0301;cia M.R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carvalho, Vinicius F.</au><au>Barreto, Emiliano O.</au><au>Diaz, Bruno L.</au><au>Serra, Magda F.</au><au>Azevedo, Viviane</au><au>Cordeiro, Renato S.B.</au><au>Martins, Marco A.</au><au>e Silva, Patrı&#x0301;cia M.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic anaphylaxis is prevented in alloxan-diabetic rats by a mechanism dependent on glucocorticoids</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2003-07-11</date><risdate>2003</risdate><volume>472</volume><issue>3</issue><spage>221</spage><epage>227</epage><pages>221-227</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>This study was undertaken to examine whether glucocorticoids could be implicated in the hyporesponsiveness of diabetic rats to systemic anaphylaxis. Rats were actively sensitized with a mixture of Al(OH)
3 plus ovalbumin and challenged i.v. with ovalbumin 14 days later. Diabetes was induced by alloxan-injected i.v. either before or after sensitization. Elevation of total and specific serum immunoglobulin E (IgE) was abolished in rats turned diabetic and then sensitised, but not in those first sensitised and then turned diabetic. In both conditions, increased serum corticosterone levels occurred in parallel with protection of diabetic animals against fatal shock, intestinal haemorrhage and elevation in plasma histamine levels evoked by antigen challenge. The resistance of diabetic rats to fatal shock was no longer significantly different from that of non-diabetic rats following treatment with the glucocorticoid receptor antagonist RU 486 (mifepristone). These findings indicate that endogenous glucocorticoid plays a pivotal role in the phenomenon of hyporeactivity to systemic anaphylaxis in alloxan-diabetic rats.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12871757</pmid><doi>10.1016/S0014-2999(03)01934-4</doi><tpages>7</tpages></addata></record> |
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| subjects | Anaphylaxis - blood Anaphylaxis - prevention & control Animals Biological and medical sciences Diabetes Diabetes Mellitus, Experimental - blood Glucocorticoid Glucocorticoids - blood Male Mast cell Medical sciences Mifepristone - pharmacology Rats Rats, Wistar Receptors, Glucocorticoid - antagonists & inhibitors Receptors, Glucocorticoid - metabolism Systemic anaphylaxis |
| title | Systemic anaphylaxis is prevented in alloxan-diabetic rats by a mechanism dependent on glucocorticoids |
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