Human papillomaviruses: targeting differentiating epithelial cells for malignant transformation
Human papillomavirus (HPV) infections play a crucial role in the pathogenesis of cervical neoplasia. Insights into the mechanisms by which HPV infection can, in a small numbers of cases, result in malignancy, comes from the observation that three proteins encoded by high-risk genital HPVs, E6, E7 an...
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| Veröffentlicht in: | Oncogene 2003-08, Vol.22 (33), p.5201-5207 |
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| creator | Fehrmann, Frauke Laimins, Laimonis A |
| description | Human papillomavirus (HPV) infections play a crucial role in the pathogenesis of cervical neoplasia. Insights into the mechanisms by which HPV infection can, in a small numbers of cases, result in malignancy, comes from the observation that three proteins encoded by high-risk genital HPVs, E6, E7 and to a lesser extent E5, target factors that control the cell cycle and proliferation. These interactions result in abrogation of cell cycle control, chromosomal alterations, telomerase activation, and eventual cell immortalization. In this review, we discuss the functions of E6, E7, and E5 proteins that are most relevant to the malignant progression of HPV-transformed cells. |
| doi_str_mv | 10.1038/sj.onc.1206554 |
| format | Article |
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Insights into the mechanisms by which HPV infection can, in a small numbers of cases, result in malignancy, comes from the observation that three proteins encoded by high-risk genital HPVs, E6, E7 and to a lesser extent E5, target factors that control the cell cycle and proliferation. These interactions result in abrogation of cell cycle control, chromosomal alterations, telomerase activation, and eventual cell immortalization. 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Insights into the mechanisms by which HPV infection can, in a small numbers of cases, result in malignancy, comes from the observation that three proteins encoded by high-risk genital HPVs, E6, E7 and to a lesser extent E5, target factors that control the cell cycle and proliferation. These interactions result in abrogation of cell cycle control, chromosomal alterations, telomerase activation, and eventual cell immortalization. In this review, we discuss the functions of E6, E7, and E5 proteins that are most relevant to the malignant progression of HPV-transformed cells.</description><subject>Apoptosis</subject><subject>Cell activation</subject><subject>Cell Biology</subject><subject>Cell cycle</subject><subject>Cell Differentiation</subject><subject>Cell Division</subject><subject>Cell immortalization</subject><subject>Cell Transformation, Neoplastic</subject><subject>Cervical cancer</subject><subject>Epithelial cells</subject><subject>Epithelial Cells - virology</subject><subject>Genome, Viral</subject><subject>Genomes</subject><subject>Human Genetics</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Immortalization</subject><subject>Infections</subject><subject>Internal Medicine</subject><subject>Malignancy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Models, Genetic</subject><subject>Oncogene Proteins, Viral - physiology</subject><subject>Oncology</subject><subject>Papillomaviridae</subject><subject>Papillomaviridae - pathogenicity</subject><subject>Proteins</subject><subject>review</subject><subject>Telomerase</subject><subject>Transformed cells</subject><subject>Womens health</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk2LFDEQhoMo7jh69aY0Ct56Nh-dpONtWdxdYcGLnkM6XWkzdCdt0i347804AyOyi-QQUvXUW1XhReg1wTuCWXuZ97sY7I5QLDhvnqANaaSoOVfNU7TBiuNaUUYv0Iuc9xhjqTB9ji4IVQRTLjdI362TCdVsZj-OcTI_fVoz5I_VYtIAiw9D1XvnIEFYvPnzhtkv32H0ZqwsjGOuXEzVZEY_BBOWakkm5BKaCh3DS_TMmTHDq9O9Rd9uPn29vqvvv9x-vr66ry1vxFIzJ5joLBhOrKE9x8JZRTvpKLhO9ZY2TljqqBOKSddJ2ZJe9oYroxjraMe26MNRd07xxwp50ZPPh_FMgLhmLVnTcozb_4KkbUWLS5stev8PuI9rCmUJTUVDGFVCHOTePUpRyZhqSHuWGswI2gcXyyfZQ199RVpFZEM4LdTuAaqcHiZvYwDnS_yhAptizgmcnpOfTPqlCdYHd-i818Ud-uSOUvD2NOzaTdCf8ZMdCnB5BHJJhQHSeZtHJd8cK4JZ1gR_SR7zvwEu7M-a</recordid><startdate>20030811</startdate><enddate>20030811</enddate><creator>Fehrmann, Frauke</creator><creator>Laimins, Laimonis A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030811</creationdate><title>Human papillomaviruses: targeting differentiating epithelial cells for malignant transformation</title><author>Fehrmann, Frauke ; Laimins, Laimonis A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-3f636bcea51ca2d506fc92b7f2efb9dc24f6c2f2f6937fb7781d7da59a933b2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Apoptosis</topic><topic>Cell activation</topic><topic>Cell Biology</topic><topic>Cell cycle</topic><topic>Cell Differentiation</topic><topic>Cell Division</topic><topic>Cell immortalization</topic><topic>Cell Transformation, Neoplastic</topic><topic>Cervical cancer</topic><topic>Epithelial cells</topic><topic>Epithelial Cells - 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| subjects | Apoptosis Cell activation Cell Biology Cell cycle Cell Differentiation Cell Division Cell immortalization Cell Transformation, Neoplastic Cervical cancer Epithelial cells Epithelial Cells - virology Genome, Viral Genomes Human Genetics Human papillomavirus Humans Immortalization Infections Internal Medicine Malignancy Medicine Medicine & Public Health Models, Genetic Oncogene Proteins, Viral - physiology Oncology Papillomaviridae Papillomaviridae - pathogenicity Proteins review Telomerase Transformed cells Womens health |
| title | Human papillomaviruses: targeting differentiating epithelial cells for malignant transformation |
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