Localization of inhibin alpha-,betaA-and betaB-subunits and aromatase in ovarian follicles with granulosa theca cell tumor (GTCT) in 6 mares
To clarify the morphological and immunohistochemical characteristics in mares with granulosa theca cell tumor (GTCT), the localization of inhibin subunits (alpha, betaA, betaB) and aromatase in the granulosa cell layers and theca layers in the ovarian follicles were determined by immunohistochemical...
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| Veröffentlicht in: | Journal of veterinary medical science 2003-06, Vol.65 (6), p.713-717 |
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| creator | Hoque, Md.S. (Iwate Univ., Morioka (Japan). Faculty of Agriculture) Derar, R.I Senba, H Osawa, T Kano, K Taya, K Miyake, Y |
| description | To clarify the morphological and immunohistochemical characteristics in mares with granulosa theca cell tumor (GTCT), the localization of inhibin subunits (alpha, betaA, betaB) and aromatase in the granulosa cell layers and theca layers in the ovarian follicles were determined by immunohistochemical staining. The follicles were obtained from the ovaries of 6 mares with GTCT and 4 normal mares as controls. Immunohistochemically, inhibin alpha-subunit was localized in the granulosa cells of all follicles showing different sizes in all GTCT cases and betaA- subunit was localized in two GTCT cases in all sized follicles. But inhibin betaB- subunit and aromatase were not localized in GTCT cases. On the other hand, inhibin alpha-, betaA-, and betaB-subunits and aromatase were localized in the large and medium sized follicles, but inhibin betaA- and betaB-subunits and aromatase were not stained in the small sized follicles in normal cases. These findings suggest that some mares with GTCT can secrete dimeric inhibin (inhibin A), but all GTCT cases cannot secrete inhibin B. By the results of aromatase staining it is clear that testosterone is not converted into estradiol due to the lack of aromatase in the GTCT follicles. |
| doi_str_mv | 10.1292/jvms.65.713 |
| format | Article |
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(Iwate Univ., Morioka (Japan). Faculty of Agriculture) ; Derar, R.I ; Senba, H ; Osawa, T ; Kano, K ; Taya, K ; Miyake, Y</creator><creatorcontrib>Hoque, Md.S. (Iwate Univ., Morioka (Japan). Faculty of Agriculture) ; Derar, R.I ; Senba, H ; Osawa, T ; Kano, K ; Taya, K ; Miyake, Y</creatorcontrib><description>To clarify the morphological and immunohistochemical characteristics in mares with granulosa theca cell tumor (GTCT), the localization of inhibin subunits (alpha, betaA, betaB) and aromatase in the granulosa cell layers and theca layers in the ovarian follicles were determined by immunohistochemical staining. The follicles were obtained from the ovaries of 6 mares with GTCT and 4 normal mares as controls. Immunohistochemically, inhibin alpha-subunit was localized in the granulosa cells of all follicles showing different sizes in all GTCT cases and betaA- subunit was localized in two GTCT cases in all sized follicles. But inhibin betaB- subunit and aromatase were not localized in GTCT cases. On the other hand, inhibin alpha-, betaA-, and betaB-subunits and aromatase were localized in the large and medium sized follicles, but inhibin betaA- and betaB-subunits and aromatase were not stained in the small sized follicles in normal cases. These findings suggest that some mares with GTCT can secrete dimeric inhibin (inhibin A), but all GTCT cases cannot secrete inhibin B. By the results of aromatase staining it is clear that testosterone is not converted into estradiol due to the lack of aromatase in the GTCT follicles.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.65.713</identifier><identifier>PMID: 12867732</identifier><language>eng</language><publisher>Japan</publisher><subject>Animals ; Aromatase - metabolism ; BIOCHEMISTRY ; Female ; GRANULOSA CELLS ; Horse Diseases - enzymology ; Horse Diseases - metabolism ; Horses - metabolism ; IMMUNOLOGY ; Inhibins - metabolism ; MARES ; Ovarian Follicle - enzymology ; Ovarian Follicle - metabolism ; Ovarian Follicle - pathology ; OVARIAN FOLLICLES ; Ovarian Neoplasms - enzymology ; Ovarian Neoplasms - metabolism ; Ovarian Neoplasms - pathology ; Ovarian Neoplasms - veterinary ; Ovary - metabolism ; Ovary - pathology ; Protein Subunits - metabolism</subject><ispartof>Journal of veterinary medical science, 2003-06, Vol.65 (6), p.713-717</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1913-9c63cfadc556ee21336eed5f78cf9444eecb9c29c4f1d1b580e496c51a1479a3</citedby><cites>FETCH-LOGICAL-c1913-9c63cfadc556ee21336eed5f78cf9444eecb9c29c4f1d1b580e496c51a1479a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12867732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoque, Md.S. (Iwate Univ., Morioka (Japan). Faculty of Agriculture)</creatorcontrib><creatorcontrib>Derar, R.I</creatorcontrib><creatorcontrib>Senba, H</creatorcontrib><creatorcontrib>Osawa, T</creatorcontrib><creatorcontrib>Kano, K</creatorcontrib><creatorcontrib>Taya, K</creatorcontrib><creatorcontrib>Miyake, Y</creatorcontrib><title>Localization of inhibin alpha-,betaA-and betaB-subunits and aromatase in ovarian follicles with granulosa theca cell tumor (GTCT) in 6 mares</title><title>Journal of veterinary medical science</title><addtitle>J Vet Med Sci</addtitle><description>To clarify the morphological and immunohistochemical characteristics in mares with granulosa theca cell tumor (GTCT), the localization of inhibin subunits (alpha, betaA, betaB) and aromatase in the granulosa cell layers and theca layers in the ovarian follicles were determined by immunohistochemical staining. The follicles were obtained from the ovaries of 6 mares with GTCT and 4 normal mares as controls. Immunohistochemically, inhibin alpha-subunit was localized in the granulosa cells of all follicles showing different sizes in all GTCT cases and betaA- subunit was localized in two GTCT cases in all sized follicles. But inhibin betaB- subunit and aromatase were not localized in GTCT cases. On the other hand, inhibin alpha-, betaA-, and betaB-subunits and aromatase were localized in the large and medium sized follicles, but inhibin betaA- and betaB-subunits and aromatase were not stained in the small sized follicles in normal cases. These findings suggest that some mares with GTCT can secrete dimeric inhibin (inhibin A), but all GTCT cases cannot secrete inhibin B. By the results of aromatase staining it is clear that testosterone is not converted into estradiol due to the lack of aromatase in the GTCT follicles.</description><subject>Animals</subject><subject>Aromatase - metabolism</subject><subject>BIOCHEMISTRY</subject><subject>Female</subject><subject>GRANULOSA CELLS</subject><subject>Horse Diseases - enzymology</subject><subject>Horse Diseases - metabolism</subject><subject>Horses - metabolism</subject><subject>IMMUNOLOGY</subject><subject>Inhibins - metabolism</subject><subject>MARES</subject><subject>Ovarian Follicle - enzymology</subject><subject>Ovarian Follicle - metabolism</subject><subject>Ovarian Follicle - pathology</subject><subject>OVARIAN FOLLICLES</subject><subject>Ovarian Neoplasms - enzymology</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovarian Neoplasms - veterinary</subject><subject>Ovary - metabolism</subject><subject>Ovary - pathology</subject><subject>Protein Subunits - metabolism</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE9v1DAUxC0EokvhxBnkU0UFWfwvdnxsV7QUrQSHvVsvjt115cSLnbQqn4EPTaJdidM8Pf1mNBqE3lOypkyzrw-PfVnLeq0of4FWlAtVKcH1S7QimspKsZqcoTelPBDCqJD6NTqjrJFKcbZCf7fJQgx_YAxpwMnjMOxDGwYM8bCH6kvrRriqYOjwcl1XZWqnIYwFLy_IqYcRiptdOD1CDjBgn2IMNrqCn8K4x_cZhimmAnjcOwvYuhjxOPUp40-3u83ucvFK3EN25S165SEW9-6k52h38223-V5tf97eba62laWa8kpbya2Hzta1dI5Rzmfpaq8a67UQwjnbasu0FZ52tK0b4oSWtqZAhdLAz9HFMfaQ0-_JldH0oSy9YHBpKkZx0Qit-Ax-PoI2p1Ky8-aQw9z02VBilu3Nsr2RtZm3n-mPp9ip7V33nz2NPQMfjoCHZOA-h2J-_GKECEK4ajj_B8wYikY</recordid><startdate>200306</startdate><enddate>200306</enddate><creator>Hoque, Md.S. (Iwate Univ., Morioka (Japan). Faculty of Agriculture)</creator><creator>Derar, R.I</creator><creator>Senba, H</creator><creator>Osawa, T</creator><creator>Kano, K</creator><creator>Taya, K</creator><creator>Miyake, Y</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200306</creationdate><title>Localization of inhibin alpha-,betaA-and betaB-subunits and aromatase in ovarian follicles with granulosa theca cell tumor (GTCT) in 6 mares</title><author>Hoque, Md.S. (Iwate Univ., Morioka (Japan). Faculty of Agriculture) ; Derar, R.I ; Senba, H ; Osawa, T ; Kano, K ; Taya, K ; Miyake, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1913-9c63cfadc556ee21336eed5f78cf9444eecb9c29c4f1d1b580e496c51a1479a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Aromatase - metabolism</topic><topic>BIOCHEMISTRY</topic><topic>Female</topic><topic>GRANULOSA CELLS</topic><topic>Horse Diseases - enzymology</topic><topic>Horse Diseases - metabolism</topic><topic>Horses - metabolism</topic><topic>IMMUNOLOGY</topic><topic>Inhibins - metabolism</topic><topic>MARES</topic><topic>Ovarian Follicle - enzymology</topic><topic>Ovarian Follicle - metabolism</topic><topic>Ovarian Follicle - pathology</topic><topic>OVARIAN FOLLICLES</topic><topic>Ovarian Neoplasms - enzymology</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovarian Neoplasms - veterinary</topic><topic>Ovary - metabolism</topic><topic>Ovary - pathology</topic><topic>Protein Subunits - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoque, Md.S. (Iwate Univ., Morioka (Japan). Faculty of Agriculture)</creatorcontrib><creatorcontrib>Derar, R.I</creatorcontrib><creatorcontrib>Senba, H</creatorcontrib><creatorcontrib>Osawa, T</creatorcontrib><creatorcontrib>Kano, K</creatorcontrib><creatorcontrib>Taya, K</creatorcontrib><creatorcontrib>Miyake, Y</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoque, Md.S. (Iwate Univ., Morioka (Japan). Faculty of Agriculture)</au><au>Derar, R.I</au><au>Senba, H</au><au>Osawa, T</au><au>Kano, K</au><au>Taya, K</au><au>Miyake, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Localization of inhibin alpha-,betaA-and betaB-subunits and aromatase in ovarian follicles with granulosa theca cell tumor (GTCT) in 6 mares</atitle><jtitle>Journal of veterinary medical science</jtitle><addtitle>J Vet Med Sci</addtitle><date>2003-06</date><risdate>2003</risdate><volume>65</volume><issue>6</issue><spage>713</spage><epage>717</epage><pages>713-717</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>To clarify the morphological and immunohistochemical characteristics in mares with granulosa theca cell tumor (GTCT), the localization of inhibin subunits (alpha, betaA, betaB) and aromatase in the granulosa cell layers and theca layers in the ovarian follicles were determined by immunohistochemical staining. The follicles were obtained from the ovaries of 6 mares with GTCT and 4 normal mares as controls. Immunohistochemically, inhibin alpha-subunit was localized in the granulosa cells of all follicles showing different sizes in all GTCT cases and betaA- subunit was localized in two GTCT cases in all sized follicles. But inhibin betaB- subunit and aromatase were not localized in GTCT cases. On the other hand, inhibin alpha-, betaA-, and betaB-subunits and aromatase were localized in the large and medium sized follicles, but inhibin betaA- and betaB-subunits and aromatase were not stained in the small sized follicles in normal cases. These findings suggest that some mares with GTCT can secrete dimeric inhibin (inhibin A), but all GTCT cases cannot secrete inhibin B. By the results of aromatase staining it is clear that testosterone is not converted into estradiol due to the lack of aromatase in the GTCT follicles.</abstract><cop>Japan</cop><pmid>12867732</pmid><doi>10.1292/jvms.65.713</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Aromatase - metabolism BIOCHEMISTRY Female GRANULOSA CELLS Horse Diseases - enzymology Horse Diseases - metabolism Horses - metabolism IMMUNOLOGY Inhibins - metabolism MARES Ovarian Follicle - enzymology Ovarian Follicle - metabolism Ovarian Follicle - pathology OVARIAN FOLLICLES Ovarian Neoplasms - enzymology Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Ovarian Neoplasms - veterinary Ovary - metabolism Ovary - pathology Protein Subunits - metabolism |
| title | Localization of inhibin alpha-,betaA-and betaB-subunits and aromatase in ovarian follicles with granulosa theca cell tumor (GTCT) in 6 mares |
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