Locking and Unlocking of Ribosomal Motions

During the ribosomal translocation, the binding of elongation factor G (EF-G) to the pretranslocational ribosome leads to a ratchet-like rotation of the 30S subunit relative to the 50S subunit in the direction of the mRNA movement. By means of cryo-electron microscopy we observe that this rotation i...

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Veröffentlicht in:	Cell 2003-07, Vol.114 (1), p.123-134
Hauptverfasser:	Valle, Mikel, Zavialov, Andrey, Sengupta, Jayati, Rawat, Urmila, Ehrenberg, Måns, Frank, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites - genetics Cryoelectron Microscopy Eukaryotic Cells - metabolism Eukaryotic Cells - ultrastructure Models, Molecular Molecular Conformation Peptide Elongation Factor G - genetics Peptide Elongation Factor G - metabolism Peptides - genetics Peptides - metabolism Protein Biosynthesis - genetics Protein Structure, Tertiary - genetics Protein Subunits - genetics Protein Subunits - metabolism Ribosomes - genetics Ribosomes - metabolism Ribosomes - ultrastructure RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Messenger - ultrastructure RNA, Transfer - genetics RNA, Transfer - metabolism RNA, Transfer - ultrastructure Rotation
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