Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder
We performed a genome-wide scan for susceptibility loci in bipolar disorder in a study sample colleted from the isolated Finnish population, consisting of 41 families with at least two affected siblings. We identified one distinct locus on 16p12 providing significant evidence for linkage in two-poin...
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| Veröffentlicht in: | Human molecular genetics 2003-08, Vol.12 (15), p.1907-1915 |
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| container_end_page | 1915 |
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| container_issue | 15 |
| container_start_page | 1907 |
| container_title | Human molecular genetics |
| container_volume | 12 |
| creator | Ekholm, Jenny M. Kieseppä, Tuula Hiekkalinna, Tero Partonen, Timo Paunio, Tiina Perola, Markus Ekelund, Jesper Lönnqvist, Jouko Pekkarinen-Ijäs, Petra Peltonen, Leena |
| description | We performed a genome-wide scan for susceptibility loci in bipolar disorder in a study sample colleted from the isolated Finnish population, consisting of 41 families with at least two affected siblings. We identified one distinct locus on 16p12 providing significant evidence for linkage in two-point analysis (Zmax=3.4). Furthermore, three loci with a two-point LOD score >2.0 were observed with markers on 4q32, 12q23 and Xq25, the latter locus having been earlier identified in one extended Finnish pedigree. In the second stage we fine mapped these chromosomal regions and also genotyped additional family members. In the fine mapping stage, 4q32 provided significant evidence of linkage for the three-point analyses (Zmax=3.6) and 16p12 produced a three-point LOD score of 2.7. Since the identified chromosomal regions replicate earlier linkage findings in either bipolar disorder or other mental disorders, they should be considered good targets for further genetic analyses. |
| doi_str_mv | 10.1093/hmg/ddg199 |
| format | Article |
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We identified one distinct locus on 16p12 providing significant evidence for linkage in two-point analysis (Zmax=3.4). Furthermore, three loci with a two-point LOD score >2.0 were observed with markers on 4q32, 12q23 and Xq25, the latter locus having been earlier identified in one extended Finnish pedigree. In the second stage we fine mapped these chromosomal regions and also genotyped additional family members. In the fine mapping stage, 4q32 provided significant evidence of linkage for the three-point analyses (Zmax=3.6) and 16p12 produced a three-point LOD score of 2.7. Since the identified chromosomal regions replicate earlier linkage findings in either bipolar disorder or other mental disorders, they should be considered good targets for further genetic analyses.</description><identifier>ISSN: 0964-6906</identifier><identifier>EISSN: 1460-2083</identifier><identifier>DOI: 10.1093/hmg/ddg199</identifier><identifier>PMID: 12874110</identifier><identifier>CODEN: HNGEE5</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Alleles ; Biological and medical sciences ; Bipolar Disorder - genetics ; Chromosome Mapping ; Chromosomes, Human, Pair 16 - genetics ; Chromosomes, Human, Pair 4 - genetics ; Finland ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease - genetics ; Genome, Human ; Humans ; Lod Score ; Microsatellite Repeats - genetics ; Molecular and cellular biology ; Monte Carlo Method</subject><ispartof>Human molecular genetics, 2003-08, Vol.12 (15), p.1907-1915</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Aug 1, 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-a8ae72615f8b41ec9bbad320dc338c1b6d8621848acefeda35bbbeca0a8aa4463</citedby><cites>FETCH-LOGICAL-c476t-a8ae72615f8b41ec9bbad320dc338c1b6d8621848acefeda35bbbeca0a8aa4463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14980724$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12874110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ekholm, Jenny M.</creatorcontrib><creatorcontrib>Kieseppä, Tuula</creatorcontrib><creatorcontrib>Hiekkalinna, Tero</creatorcontrib><creatorcontrib>Partonen, Timo</creatorcontrib><creatorcontrib>Paunio, Tiina</creatorcontrib><creatorcontrib>Perola, Markus</creatorcontrib><creatorcontrib>Ekelund, Jesper</creatorcontrib><creatorcontrib>Lönnqvist, Jouko</creatorcontrib><creatorcontrib>Pekkarinen-Ijäs, Petra</creatorcontrib><creatorcontrib>Peltonen, Leena</creatorcontrib><title>Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder</title><title>Human molecular genetics</title><addtitle>Hum. Mol. Genet</addtitle><description>We performed a genome-wide scan for susceptibility loci in bipolar disorder in a study sample colleted from the isolated Finnish population, consisting of 41 families with at least two affected siblings. We identified one distinct locus on 16p12 providing significant evidence for linkage in two-point analysis (Zmax=3.4). Furthermore, three loci with a two-point LOD score >2.0 were observed with markers on 4q32, 12q23 and Xq25, the latter locus having been earlier identified in one extended Finnish pedigree. In the second stage we fine mapped these chromosomal regions and also genotyped additional family members. In the fine mapping stage, 4q32 provided significant evidence of linkage for the three-point analyses (Zmax=3.6) and 16p12 produced a three-point LOD score of 2.7. Since the identified chromosomal regions replicate earlier linkage findings in either bipolar disorder or other mental disorders, they should be considered good targets for further genetic analyses.</description><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - genetics</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 16 - genetics</subject><subject>Chromosomes, Human, Pair 4 - genetics</subject><subject>Finland</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genome, Human</subject><subject>Humans</subject><subject>Lod Score</subject><subject>Microsatellite Repeats - genetics</subject><subject>Molecular and cellular biology</subject><subject>Monte Carlo Method</subject><issn>0964-6906</issn><issn>1460-2083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1rFTEUBuBQlPZau-kPkFDQRWHanCQ3H8tS-iFekKJCcRPyNTXt3Mk0mSn23zt6LxbcuMoiT15OzovQIZATIJqd_ljfnYZwB1rvoAVwQRpKFHuFFkQL3ghNxB56U-s9ISA4k7toD6iSHIAs0OXFUwqx9xHnFtep-jiMyaUujc-4yz7h3GP-yCi2fcAgBqC4zQW7NOTOFhxSzSXE8ha9bm1X48H23EffLi--nl83q89XH8_PVo3nUoyNVTZKKmDZKscheu2cDYyS4BlTHpwISlBQXFkf2xgsWzrnordkfmg5F2wffdjkDiU_TrGOZp3mmbvO9jFP1UjGFWgp_wtBKeD6T-LRP_A-T6WfP2EoABVKA5vR8Qb5kmstsTVDSWtbng0Q87sDM3dgNh3M-N02cXLrGF7odukzeL8FtnrbtcX2PtUXx7UikvLZNRuX6hh__r235cEIyeTSXN9-N7efxBX7sroxjP0CxJqdeg</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Ekholm, Jenny M.</creator><creator>Kieseppä, Tuula</creator><creator>Hiekkalinna, Tero</creator><creator>Partonen, Timo</creator><creator>Paunio, Tiina</creator><creator>Perola, Markus</creator><creator>Ekelund, Jesper</creator><creator>Lönnqvist, Jouko</creator><creator>Pekkarinen-Ijäs, Petra</creator><creator>Peltonen, Leena</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder</title><author>Ekholm, Jenny M. ; Kieseppä, Tuula ; Hiekkalinna, Tero ; Partonen, Timo ; Paunio, Tiina ; Perola, Markus ; Ekelund, Jesper ; Lönnqvist, Jouko ; Pekkarinen-Ijäs, Petra ; Peltonen, Leena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-a8ae72615f8b41ec9bbad320dc338c1b6d8621848acefeda35bbbeca0a8aa4463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - genetics</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 16 - genetics</topic><topic>Chromosomes, Human, Pair 4 - genetics</topic><topic>Finland</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genome, Human</topic><topic>Humans</topic><topic>Lod Score</topic><topic>Microsatellite Repeats - genetics</topic><topic>Molecular and cellular biology</topic><topic>Monte Carlo Method</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ekholm, Jenny M.</creatorcontrib><creatorcontrib>Kieseppä, Tuula</creatorcontrib><creatorcontrib>Hiekkalinna, Tero</creatorcontrib><creatorcontrib>Partonen, Timo</creatorcontrib><creatorcontrib>Paunio, Tiina</creatorcontrib><creatorcontrib>Perola, Markus</creatorcontrib><creatorcontrib>Ekelund, Jesper</creatorcontrib><creatorcontrib>Lönnqvist, Jouko</creatorcontrib><creatorcontrib>Pekkarinen-Ijäs, Petra</creatorcontrib><creatorcontrib>Peltonen, Leena</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human molecular genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ekholm, Jenny M.</au><au>Kieseppä, Tuula</au><au>Hiekkalinna, Tero</au><au>Partonen, Timo</au><au>Paunio, Tiina</au><au>Perola, Markus</au><au>Ekelund, Jesper</au><au>Lönnqvist, Jouko</au><au>Pekkarinen-Ijäs, Petra</au><au>Peltonen, Leena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder</atitle><jtitle>Human molecular genetics</jtitle><addtitle>Hum. Mol. Genet</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>12</volume><issue>15</issue><spage>1907</spage><epage>1915</epage><pages>1907-1915</pages><issn>0964-6906</issn><eissn>1460-2083</eissn><coden>HNGEE5</coden><abstract>We performed a genome-wide scan for susceptibility loci in bipolar disorder in a study sample colleted from the isolated Finnish population, consisting of 41 families with at least two affected siblings. We identified one distinct locus on 16p12 providing significant evidence for linkage in two-point analysis (Zmax=3.4). Furthermore, three loci with a two-point LOD score >2.0 were observed with markers on 4q32, 12q23 and Xq25, the latter locus having been earlier identified in one extended Finnish pedigree. In the second stage we fine mapped these chromosomal regions and also genotyped additional family members. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Alleles Biological and medical sciences Bipolar Disorder - genetics Chromosome Mapping Chromosomes, Human, Pair 16 - genetics Chromosomes, Human, Pair 4 - genetics Finland Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease - genetics Genome, Human Humans Lod Score Microsatellite Repeats - genetics Molecular and cellular biology Monte Carlo Method |
| title | Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder |
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